Iimveliso

(αS, 3S) -α-[(tert-Butyloxycarbonyl) amino] -2-oxo-3-pyrrolidinepropanoic acid methyl ester, eyaziwa ngokuba yi-Boc-Amino acid methyl ester, yinto ebalulekileyo kwintsimi ye-organic synthesis kunye ne-peptide. i-chemistry.I-Boc-Amino acid i-methyl ester isebenza njengendlela ekhuselweyo ye-amino acids, apho iqela le-Boc (tert-butyloxycarbonyl) lisetyenziselwa ukukhusela iqela le-amino ngexesha lokuphendula.Le khompawundi isetyenziswa ngokuyinhloko kwi-peptide synthesis ukwazisa i-amino acids ezithile kwii-peptide chain.Babandakanyeka kwiinkqubo ezahlukeneyo ezifana nokubonakaliswa, ukulawulwa kwe-enzyme, kunye nenkxaso yesakhiwo.I-peptide synthesis ibandakanya i-stepwise assembly of amino acids ukudala ulandelelwano oluthile olufanisa iipeptides zendalo okanye ukudala izakhiwo ezinoveli ezineempawu ezinqwenelekayo.I-Boc-Amino acid methyl ester iqhele ukusetyenziswa njengebhloko yokwakha kwi-soli-phase peptide synthesis (SPPS), enye yezona ndlela zisetyenziswa kakhulu ukwenza iipeptides.Kwi-SPPS, ikhonkco le-peptide lidityaniswe ngendlela yenyathelo kwinkxaso eqinileyo, ngokuqhelekileyo kusetyenziswa i-amino acid ephuma kunye neqela elikhuselayo lethutyana.I-Boc-Amino acid methyl ester yinto efanelekileyo yokuqala ye-SPPS ngenxa yokuzinza kwayo, ukunyibilika, kunye nokuhambelana nezinye i-peptide synthesis reagents.Ngexesha le-peptide synthesis, i-Boc-Amino acid i-methyl ester yongezwa kwikhonkco elikhulayo le-peptide ngokusebenzisa i-amide bond formation.Iqela elikhuselayo le-Boc lithintela ukuphendula okungafunekiyo kwaye liqinisekisa ukudibanisa okukhethiweyo kwe-amino acid kwikhonkco le-peptide.Emva kokuba ulandelelwano olufunwayo lufezekisiwe, iqela le-Boc lisuswa phantsi kweemeko ezithambileyo, lityhila iqela le-amino lamahhala ukwenzela uhlengahlengiso olongezelelweyo okanye i-peptide characterization.Ukongezelela kwi-peptide synthesis, i-Boc-Amino acid methyl ester ingasetyenziselwa ukulungiswa kweentlobo ezahlukeneyo zamachiza. i-intermediates, agrochemicals, kunye nezinye iikhompawundi eziphilayo.Ukuphathwa kwayo ngokulula, ukuzinza, kunye nokuhambelana neemeko zokuphendula ezisemgangathweni kwenza kube yinto eguquguqukayo yokwakha i-organic synthesis.Kuko konke, i-Boc-Amino acid methyl ester sisixhobo esibalulekileyo kwi-peptide synthesis kunye ne-organic chemistry.Indima yayo njengendlela ekhuselweyo ye-amino acids ivumela ukuhlanganiswa okusebenzayo kwamatyathanga e-peptide kunye nokudalwa kwezakhiwo ezahlukeneyo ze-peptide zophando, ukufunyanwa kweziyobisi, kunye nezicelo zonyango.