I-β-Alanine CAS: 107-95-9 I-crystalline powder emhlophe
| Inombolo Yekhathalogu | XD90324 |
| Igama lemveliso | β-Alanine |
| CAS | 107-95-9 |
| Ifomula yeemolekyuli | C3H7NO2 |
| Ubunzima beMolekyuli | 89.09 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29224920 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe wekristale |
| Isivavanyi | 99% |
Isifo sesibindi esinamafutha angasinxilisayo (NAFLD) sinoluhlu olubanzi lwezifo ezisuka kwi-steatosis ephakathi ebonakaliswe ngokugcinwa okungaqhelekanga kweelipids ngaphakathi kweeseli zesibindi ukuya kwi-steatohepatitis (NASH) ebonisa ukuqokelelwa kwamafutha, ukuvutha, ibhaluni kunye nokuthotywa kwe-hepatocytes, kunye ne-fibrosis.Ekugqibeleni, i-steatohepatitis ingabangela i-cirrhosis yesibindi kunye ne-hepatocellular carcinoma.Kolu phononongo siye sahlalutya iintlobo ezintathu zemouse, i-A / J, i-C57BL / 6J, kunye ne-PWD / PhJ, ebonisa idigri ezahlukeneyo ze-steatohepatitis xa ilawulwa yi-3,5-diethoxycarbonyl. -1,4-dihydrocollidine (DDC) equlethe ukutya.Uhlalutyo lwe-RNA-Seq gene expression expression, uhlalutyo lweprotheyini kunye neprofayili yemetabolism yasetyenziswa ukuchonga iijene/iiprotheyini ezichazwe ngokwahlukileyo kunye namanqanaba e-metabolite aphazamisekileyo kwiisampuli zesibindi sempuku kunyango lwe-DDC.Uhlalutyo lwendlela lubonakalise ukuguqulwa kwe-arachidonic acid (AA) kunye ne-S-adenosylmethionine (SAMe) imetabolism kwezinye iindlela.Ukuqonda utshintsho lwe-metabolic ye-arachidonic aci d metabolism ekukhanyeni kweeprofayili zokubonakaliswa kwesifo imodeli yekinetic yale ndlela yaphuhliswa kwaye yaphuculwa ngokwamanqanaba e-metabolite.Emva koko, imodeli yayisetyenziselwa ukufundisisa kwimiphumo ye-silico yeethagethi ezinokuthi zenzeke kwi-steatohepatitis.Sichonge i-AA / i-eicosanoid imetabolism njengento ephazamisayo kakhulu kwiigundane ezibangelwa yi-DDC zisebenzisa inhlanganisela yovavanyo kunye nendlela ye-silico.Uhlalutyo lwethu lwe-AA / eicosanoid indlela ye-metabolic iphakamisa ukuba i-5-hydroxyeicosatetraenoic acid (5-HETE), i-15-hydroxyeicosatetraenoic acid (15-HETE) kunye ne-prostaglandin D2 (PGD2) iphazamiseka kwiigundane ze-DDC.Siphinde sibonisa ukuba imodeli eguquguqukayo ingasetyenziselwa ukuqikelelwa komgangatho weenguqu ze-metabolic ezisekelwe kwidatha ye-transcriptomics kwimeko enxulumene nesifo.Ngaphaya koko, i-SAMe metabolism ichongiwe njengento ephazamisekileyo ngenxa yonyango lwe-DDC.Iijini ezininzi kunye neemetabolites zale modyuli zibonisa umahluko phakathi kwe-A/J kunye ne-C57BL/6J kwelinye icala kunye ne-PWD/PhJ kwelinye.
