I-1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine CAS: 61338-13-4
| Inombolo Yekhathalogu | XD93391 |
| Igama lemveliso | 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine |
| CAS | 61338-13-4 |
| Ifomu yemolekyulila | I-C17H19N3O2 |
| Ubunzima beMolekyuli | 297.35 |
| Iinkcukacha zokuGcina | I-Ambient |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| uAsay | 99% imizuzu |
I-1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, eyaziwa nangokuthi yi-CPPMP, i-chemical compound kunye nesakhiwo esiyinkimbinkimbi esineendlela ezahlukeneyo zokusebenza kwintsimi ye-chemistry yamayeza.Onye ukusetyenziswa ye-CPPMP ikunyango lwe-neurological disorders.Ubukho beqela le-carboxypyridyl lubonisa amandla alo okunxibelelana ne-neuronal receptors ethile kwinkqubo ye-nervous central.Ukujolisa ezi zamkeli kunokwenza uhlengahlengiso lwe-neurotransmission, enokukhokelela kwiziphumo zonyango kwiimeko ezinjengoxinzelelo, ixhala, okanye ukuphazamiseka kwe-neurodeergenerative.Uphando olongezelelweyo lufunekayo ukuphonononga ukusebenzisana kwe-receptor ethile kunye neendlela zesenzo se-CPPMP ukwenzela ukwandisa amandla ayo njenge-arhente yonyango yokuphazamiseka kwe-neurological.Isakhiwo se-piperazine engundoqo ye-CPPMP iphinda ibonise amandla ayo njengekhompawundi ekhokelayo yokuphuhliswa kwamachiza amatsha.Iikhemisti zamayeza zinokuguqula iindawo ezahlukeneyo zolwakhiwo ukuze ziphucule iimpawu zayo zekhemesti okanye zijolise kwiindlela ezithile zebhayoloji.Ngokulungisa isakhiwo se-CPPMP, abaphandi banokuqulunqa izinto eziphuma kuzo ngokukhetha okuphuculweyo, amandla, kunye neeprofayili zokhuseleko, okwenza ukuba babe ngabaviwa abafanelekileyo beziyobisi ezijoliswe kwizifo ezahlukahlukeneyo.Ngaphezu koko, i-phenyl ye-CPPMP kunye namaqela e-methyl anikezela izakhiwo ze-hydrophobic, ezinokuba luncedo ekuphuhliseni izidakamizwa ezinokuwela. iiseli zeseli kunye nokufikelela kwiithagethi ze-intracellular.Olu phawu lunokuxhaswa ngokuyila iziyobisi zenoveli ezijolise ngokukodwa kwi-intracellular enzymes okanye iindlela, ukubonelela ngamathuba okungenelela kwonyango kwizifo ezifana nomhlaza okanye ukuphazamiseka kwe-metabolic.Ukongezelela, iimpawu ezikhethekileyo ze-CPPMP zivumela ukuphuhliswa okunokwenzeka kweeprodrugs okanye iinkqubo zokuhanjiswa kweziyobisi. .Ngokuguqula iqela layo le-carboxypyridyl, ikhompawundi inokuyilwa ukuba izinze ngakumbi okanye ingabi netyhefu encinci kwindlela yayo yendalo, ngelixa ihambisa ngokufanelekileyo i-moiety yechiza esebenzayo kwindawo efunwayo yesenzo.Utshintsho olunjalo lunokuphucula i-bioavailability kunye nonyango olusebenzayo lwekhompawundi.Kufuneka kuqatshelwe ukuba ukusetyenziswa kwe-CPPMP kwezi zicelo ezinokubakho kuyaqikelelwa kwaye kuya kufuna uphando olubalulekileyo kunye nophuhliso phambi kokusetyenziswa okusebenzayo.Ngaphezu koko, konke ukusetyenziswa kwe-CPPMP kuya kufuneka kulandele iiprothokholi zokhuseleko ezimiselweyo kunye nezikhokelo zokuqinisekisa ukuphathwa ngokufanelekileyo kunye nokunciphisa umngcipheko.Ekuqukumbeleni, i-1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, okanye i-CPPMP. , ubambe isithembiso kwizicelo ezahlukeneyo kwi-chemistry yamayeza.Isakhiwo sayo esiyinkimbinkimbi sibonisa amathuba okuphuhliswa kwee-agent zonyango ezinoveli kwiingxaki ze-neurological, kunye neziyobisi ezijolise kwizifo ezahlukeneyo.Ngophando olongezelelweyo kunye nokuphucula, i-CPPMP inamandla okwenza igalelo elibalulekileyo kwintsimi yeyeza kunye nokuphucula iziphumo zesigulane.
