Iimveliso

I-1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine yikhemikhali yekhemikhali enokuthi ibe noluhlu olubanzi lwezicelo kwi-chemistry yonyango kunye nophuhliso lweziyobisi.Onye ukusetyenziswa kwesi sixhobo kwintsimi ye-chemistry yonyango. , ngokukodwa ekufumaneni iziyobisi.Ubukho beqela le-hydroxymethylpyridinyl licebisa ukusebenzisana okunokwenzeka kunye neethagethi ezithile zebhayoloji, ezifana ne-enzymes okanye i-receptors.Oosokhemisti bamayeza banokwandisa ubume bale khompawundi ukukhulisa umanyano olubophelelayo kunye nokukhetha kwiithagethi zebhayoloji ezinqwenelekayo.Ngokuguqula i-phenyl kunye ne-piperazine moieties, abaphandi banokuhlengahlengisa i-compound's physicochemical properties kunye ne-pharmacokinetics, enokukhokelela ekuphuculeni ukusetyenziswa kweziyobisi kunye nokunciphisa iziphumo ezingafunekiyo. -methyl-2-phenylpiperazine ilele kwinkalo ye-neuropharmacology.Ulwakhiwo lwale khompawundi lucebisa ukusebenzisana okunokwenzeka kunye ne-receptors kwinkqubo ye-nervous central, enokuthi ikhokelele kwiziphumo zonyango kwiingxaki ze-neurological.Ngokomzekelo, kunokuphononongwa njengomviwa wokulungelelanisa ukuhanjiswa kwe-neurotransmission kwiimeko ezifana nokuxhalaba, ukudakumba, okanye i-schizophrenia.Abaphandi banokuphanda indlela yokusebenza kwekhompawundi kwaye baqhube izifundo ze-preclinical kunye nekliniki ukuvavanya amandla ayo onyango.Ngaphezu koko, iimpawu zesakhiwo sekhompawundi zingenza ukuba zilungele izicelo zokuhanjiswa kweziyobisi.I-hydrophobic phenyl kunye namaqela e-methyl acebisa amandla okuwela i-lipid membranes, eyenza ukuba ijolise kwi-intracellular enzymes okanye iindlela.Le propati inenzuzo ekuphuhliseni amachiza afuna ukungena kwiiseli kwaye enze iziphumo zawo kwiithagethi ezithile ze-intracellular.Ngokuguqula isakhiwo se-compound, iikhemikhali zonyango zinokuphucula i-bioavailability yayo, ukuphucula ukuzinza kwayo, kunye nokuphuhlisa izicwangciso ezisebenzayo zokuhanjiswa kweziyobisi.Kubalulekile ukuba uqaphele ukuba ukusetyenziswa kwe-1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine kwezi zicelo ezinokwenzeka zifuna ukuvavanya kwangaphambili kunye nokuhlolwa kweklinikhi ukuqinisekisa ukhuseleko, ukusebenza kakuhle, kunye nedosi efanelekileyo.Izifundo ezibanzi ze-pharmacological kunye ne-toxicological ziyimfuneko ukuze kuqondwe iziphumo zayo kwiinkqubo ezahlukeneyo zebhayoloji kunye nokumisela nayiphi na imiphumo emibi enokubakho.Ngokufutshane, i-1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine yikhompawundi eneentlobo ezahlukeneyo. izicelo ezinokubakho kwikhemistri yezamayeza kunye nophuhliso lwamachiza.Ibambe isithembiso soyilo lwamachiza amatsha, ngakumbi kwimimandla ye-neuropharmacology kunye nokuhanjiswa kweziyobisi.Uphando olongezelelweyo luyafuneka ukuphonononga ukusebenzisana kwayo okuthe ngqo, indlela yokusebenza, kunye namandla onyango, ivula indlela yempumelelo enokubakho kunyango lwezifo ezahlukeneyo kunye nokuphazamiseka.