Iimveliso

I-1-Methyl-4-pyrazole boronic acid pinacol ester yikhompawundi enoluhlu olubanzi lwezicelo, ngokukodwa kwintsimi ye-organic synthesis.Ulwakhiwo lwalo olukhethekileyo kunye nokuphinda lusebenze luyenza ixabiseke kwiimpendulo zemichiza eyahlukeneyo kwaye njengebhloko yokwakha ukuhlanganiswa kweemolekyuli ezintsonkothileyo.Enye yezinto eziphambili zokusetyenziswa kwe-1-Methyl-4-pyrazole boronic acid pinacol ester kukubunjwa kwecarbon-carbon okanye iibhondi carbon-heteroatom.Iqela le-asidi ye-boronic kwi-molecule inokuthi i-Suzuki-Miyaura i-cross-coupling reactions, eyenza ukuba i-attachment ye-1-methyl-4-pyrazole moiety kwezinye iikhompawundi okanye amaqela asebenzayo.Le ndlela yokusabela ivumela iikhemisti ukuba zenze iikhompawundi ezintsonkothileyo eziphilayo kunye nezakhiwo ezilungiselelwe kunye properties.Ukwengeza, iqela pinacol ester kwi molekyuli ibonelela uzinzo kwaye ikhusela ukusebenza boronic acid ngexesha reactions ezahlukeneyo.Eli qela elikhuselayo linokususwa ngokulula phantsi kweemeko ezincinci, ngaloo ndlela libonisa iqela le-boronic acid ukwenzela ukuguqulwa okuqhubekayo.Ngenxa yoko, i-1-Methyl-4-pyrazole i-boronic acid pinacol ester isebenza njenge-intermediate ephakathi kwi-syntheuticals yamayeza, i-agrochemicals, kunye nezinye iikhemikhali ezintle. abaviwa beziyobisi.Ngokusebenzisa i-1-Methyl-4-pyrazole boronic acid pinacol ester njengento yokuqala, i-chemist inokwazisa i-1-methyl-4-pyrazole moiety kwi-molekyuli ekujoliswe kuyo, inika iimpawu ezithile okanye ukusebenza.Iikhompawundi ezibangelwayo zingabonakalisa umsebenzi ophuculweyo we-biological, ukuphuculwa kwe-pharmacokinetics, okanye ukunciphisa ubuthi.Ngaphezu koko, i-1-Methyl-4-pyrazole i-boronic acid pinacol ester ibalulekile kwisayensi yezinto eziphathekayo kunye ne-catalysis.Iyakwazi ukusebenza njenge-ligand, ukulungelelanisa kunye ne-catalysts yensimbi kunye nokuthatha inxaxheba kwiindlela ezahlukeneyo zokuphendula.Iqela le-asidi ye-boronic ye-compound inokwenza ii-complexes kunye neentsimbi zenguqu, ezivumela ukuba kusebenze i-CH bonds okanye i-catalysis ye-cross-coupling reactions.Ezi propati zenza kube luncedo ekudityanisweni kwezinto ezisebenzayo okanye uphuhliso lweenkqubo ezintsha ze-catalytic.Ngesishwankathelo, i-1-Methyl-4-pyrazole i-pinacol ester ye-boronic acid iyikhompawundi eguquguqukayo kunye nezicelo ezibalulekileyo kwi-organic synthesis, amayeza, isayensi yezinto eziphathekayo, kunye i-catalysis.Ukusebenza kwayo kwe-boronic acid kunye neqela le-pinacol ester kwenza kube luncedo kwi-carbon-carbon-carbon okanye i-carbon-heteroatom bond reaction reactions, eyenza ukwakhiwa kwee-molecule eziyinkimbinkimbi.Usetyenziso lwayo luthatha ixesha elide kumashishini ahlukeneyo, kubandakanya ukuhlanganiswa kwamayeza, uphuhliso lwezixhobo zokusebenza, kunye nokuqhubela phambili kweenkqubo ze-catalytic.I-versatility kunye ne-reactivity ye-1-Methyl-4-pyrazole boronic acid pinacol ester yenza ukuba sisixhobo esixabisekileyo kwiikhemisti ezisebenza kwi-synthesis yeekhompawundi zenoveli kunye noyilo lwezisombululo ezintsha.