1,1-Cyclobutanedicarboxylatodiammineplatinum (II) Cas:41575-94-4
| Inombolo Yekhathalogu | XD90684 |
| Igama lemveliso | 1,1-Cyclobutanedicarboxylatodiammineplatinum (II) |
| CAS | 41575-94-4 |
| Ifomula yeemolekyuli | I-C6H12N2O4Pt |
| Ubunzima beMolekyuli | 371.25 |
| Iinkcukacha zokuGcina | 2-8°C |
| IKhowudi yoMrhumo eHarmonized | 28439090 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe ukuya kumhlophe |
| Isivavanyi | 99% |
| Amanzi | ≤0.5% |
| Ilahleko ekomisweni | ≤0.5% |
| Iikloridi | ≤100ppm |
| Izinto ezinxulumeneyo | ≤0.25% |
| Nakuphi na Ukungcola Okungachazwanga | ≤ 0.1% |
| Zonke ezinye izinto ezingcolileyo | ≤0.5% |
| I-1,1-Cyclobutanedicarboxylic acid | ≤ 0.5% |
Isizukulwana sesibini seplatinam eyinkimbinkimbi antineoplastic amayeza.Umsebenzi we-antitumor kunye ne-antitumor ufana ne-cisplatin, kodwa ukunyibilika kwamanzi kungcono kune-cisplatin, kunye ne-toxicity kwizintso nayo iphantsi.Inefuthe elihle lokunyanga kumhlaza wemiphunga yeseli encinci, umhlaza we-ovarian, intloko kunye nentamo i-squamous cell carcinoma, i-testicular tumor, i-lymphoma enobungozi, njl njl.
Isizukulwana sesibini seplatinam anticancer drug ngokusisiseko sinemisebenzi efanayo kunye nokusetyenziswa njengecisplatin.Isebenza ngakumbi kune-cisplatin kwamanye amathumba, kwaye yomelele kune-cisplatin njenge-radiosensitizer phantsi kweemeko ze-hypoxic.Isetyenziswa kakhulu kumhlaza wesibeleko, umhlaza wamatyhalarha, umhlaza wemiphunga omncinci weseli kunye nomhlaza wentloko kunye nentamo.
I-Carboplatin lichiza le-anticancer elisekelwe kwiplatinam elonakalisa i-DNA ngokwenza i-intrachain conjugation kwiintsalela ze-guanine ezikufutshane.Impembelelo ye-antitumor yala machiza iphunyezwa ngokulahleka kwe-DNA engafanelekanga yokulungisa (ugonyo lwe-MMR) kunye nokungeniswa kwenkqubo yokufa kweseli.
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