Iimveliso

Ikhompawundi 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1, I-3 (2H) -i-dione yi-molecule eyinkimbinkimbi ye-organic kunye nezicelo ezinokuthi zenziwe kwiinkalo zonyango kunye namayeza.Ubukho be-isoindole core bubonisa ukuba le ngqungquthela ineempawu zesakhiwo ezihambelana ne-biologically kwaye zifunyenwe kwii-molecule ze-bioactive.I-Isoindole derivatives ixelwe ukuba ineempawu ezahlukeneyo ze-pharmacological, ezibandakanya i-antitumor, i-anti-inflammatory, kunye ne-antimicrobial activities.I-oxazolidinone moiety, emele iqela le-1,3-oxazolidin-5-yl, iyaziwa ngomsebenzi wayo wokulwa ne-antibacterial.I-Oxazolidinones isetyenziswe njengamacandelo abalulekileyo kwi-antibiotics, ingakumbi kwiibhaktheriya ezinganyangekiyo ngamachiza.Oku kuphakamisa ukuba i-compound inokuba namandla njenge-antibacterial agent.Ubukho be-morpholinone moiety, emelwe yi-4-(3-oxomorpholin-4-yl) iqela lephenyl, yongeza ubunzima obungakumbi kusetyenziso olunokwenzeka lwekhompawundi.I-Morpholines ifakwe ngokubanzi kwiikhompawundi zonyango ngenxa yokukwazi ukusebenzisana neenjongo ezahlukeneyo zebhayoloji.Iqela le-oxo kwi-morpholinone linokuthi liphucule intsebenziswano yekhompawundi kunye neethagethi ezithile, iyenze ibhloko yokwakha exabisekileyo ekufumaneni ichiza kunye nophuhliso.I-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl] - Iqela le-1,3-oxazolidin-5-yl, elifakwe kwi-isoindole core, lenza indawo esebenzayo ye-compound.Ubume bekhemikhali beqela elithile bubonisa ukuba lunokuba nokusebenzisana kunye neethagethi zebhayoloji ezifana ne-enzymes okanye i-receptors.Kuko konke, ngokusekelwe kwiimpawu zesakhiwo se-compound, unakho ukubonisa imisebenzi ye-pharmacological kwi-antibacterial, anti-inflammatory, kunye nezinye iindawo zonyango.Nangona kunjalo, ukusetyenziswa kwayo okuthe ngqo kunye neendlela zokwenza kuya kufuneka kugqitywe ngophando olongezelelweyo, kubandakanywa ne-vitro kunye ne-vivo experiments, ukuvavanya ukusebenza kwayo kunye neeprofayili zokhuseleko. -3-[4-(3-oxomorpholin-4-yl) phenyl] -1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3 (2H) -dione ibonisa isithembiso kwiinkalo zonyango kunye namayeza ngenxa yobume bayo obuntsonkothileyo kunye neempawu ezinokuthi zibekho kwi-pharmacological.Uphando lwexesha elizayo luyimfuneko ukuphonononga ukusetyenziswa kwalo okuthe ngqo, usetyenziso olunokubakho lwezonyango, kunye nokusebenza ngokubanzi.