I-2'-Deoxyuridine Cas: 951-78-0
| Inombolo Yekhathalogu | XD90583 |
| Igama lemveliso | 2'-Deoxyuridine |
| CAS | 951-78-0 |
| Ifomula yeemolekyuli | I-C9H12N2O5 |
| Ubunzima beMolekyuli | 228.20 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe ukuya kumhlophe |
| Isivavanyi | 99% |
| Indawo yokunyibilika | 164 - 168 Deg C |
| Ilahleko ekomisweni | <1.0% |
| Intsalela kwi-Ignition | <0.1% |
Ukuphuculwa kokusetyenziswa kwenitrogen ezinkomeni kubalulekile ukuze kugcinwe imveliso yenkomo ezinzileyo.Njengoko iipurines kunye neepyrimidines (PP) zenza inxenye yerumen nitrogen, ukuqonda okuphuculweyo kokufunxa kunye nemetabolism ephakathi kwePP kubalulekile.Umsebenzi okhoyo uchaza ukuphuhliswa kunye nokuqinisekiswa kwendlela ebuthathaka kunye neyodwa yokuzimisela kwangaxeshanye kwi-20 purines (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine, i-uracil, i-cytidine, i-uridine, i-thymidine, i-2'-deoxyuridine), kunye neemveliso zabo zokunciphisa (i-uric acid, i-allantoin, i-β-alanine, i-β-ureidopropionic acid, i-β-aminoisobutyric acid) kwi-plasma yegazi yeenkomo zobisi.Ubuchule obusekwe kulwelo olusekwe kwichromatography edityaniswe ne-electrospray ionization tandem mass spectrometry (LC-MS/MS) yadityaniswa nemigangatho yolungelelwaniso ehambelana ne-matrix kunye nezizinzileyo ezilebhile zereferensi ikhompawundi.Uhlalutyo lobungakanani belwandulelwe yinoveli yenkqubo yonyango yangaphambi konyango ebandakanya imvula ye-ethanol, ukuhluzwa, ukuphuphuma komphunga kunye nokulungiswa kwakhona.Iiparameters zokwahlula kunye nokufumanisa ngexesha lohlalutyo lwe-LC-MS / MS luphandwe.Kuye kwaqinisekiswa ukuba ukusebenzisa imodeli yolungelelwaniso lwelogi endaweni yemodeli yolungelelwaniso lomgca kukhokelele kwi-CV% esezantsi kunye nokungabikho kovavanyo olufanelekileyo kubonise ukuhlehla komgca owanelisayo.Indlela igubungela uluhlu loxinaniso lwemetabolite nganye ngokweesampuli zokwenene, umz. i-guanine: 0.10-5.0 μmol/L, kunye ne-allantoin: 120-500 μmol/L.I-CV% yoluhlu lobungakanani obukhethiweyo ibingaphantsi kwe-25%.Indlela inokuphinda iphindwe (CV%≤25%) kunye nokuchaneka okuphakathi (CV%≤25%) kunye nokubuyisela okugqwesileyo (91-107%).Zonke i-metabolites zibonise uzinzo oluhle lwexesha elide kunye nokuzinza okulungileyo ngaphakathi kwee-runs (CV%≤10%).Iidigri ezahlukeneyo zeziphumo zematrix ezipheleleyo zabonwa kwiplasma, umchamo kunye nobisi.Ukumiselwa kweziphumo ze-matrix ezihambelanayo zibonise ukuba indlela yayifanelekile phantse zonke ii-metabolites ze-PP ezivavanyiweyo kwiplasma ezitsalwa kwi-artery kunye ne-portal hepatic, i-hepatic kunye ne-gastrosplenic veins kwaye, ngaphandle kwezinto ezimbalwa, nakwezinye iindidi ezifana nenkukhu, ihagu, mink, umntu kunye nempuku.
