Iimveliso

I-2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (TMS-D-glucose lactone) yikhemikhali eyaziwayo ngokusetyenziswa kwayo kwi-organic synthesis, ngokukodwa kwintsimi ye-carbohydrate chemistry.Iphuma kwi-D-glucose, iswekile eyenzeka ngokwemvelo, kwaye ineempawu ezizodwa ezenza ukuba zibe luncedo kwiindlela ezahlukeneyo zeekhemikhali.Enye yezinto eziphambili zokusetyenziswa kwe-TMS-D-glucose lactone njengeqela elikhuselayo kwi-carbohydrate chemistry.I-carbohydrates, kuquka ishukela, ingaba namaqela amaninzi e-hydroxyl, anokuthi aphendule kunye nezinye ii-reagents okanye enze utshintsho olungafunekiyo ngexesha lokudibanisa.Ngokukhusela ngokukhethekileyo amaqela athile e-hydroxyl esebenzisa i-TMS-D-glucose lactone, iikhemisti zinokulawula iziphumo zokusabela kwaye zisebenzise izakhiwo ze-carbohydrate ngokufanelekileyo.Emva kokuba iimpendulo ezifunwayo zigqityiwe, amaqela akhuselayo anokususwa ngokulula, aveze imveliso efunwayo.TMS-D-glucose lactone iphinda ifumane izicelo njengephakathi kwi-synthesis ye-carbohydrate enzima derivatives.Ngokukhetha ukuguqula amaqela e-hydroxyl ye-TMS-D-glucose lactone, iikhemikhali zinokuzisa uluhlu olubanzi lwamaqela asebenzayo okanye ezinye izinto ezithatha indawo kwi-molecule ye-carbohydrate.Oku kuvumela ukudalwa kweentlobo ezahlukeneyo ze-carbohydrate-based based compounds kunye nezicelo ezinokubakho kumachiza, izimonyo, kunye nesayensi yezinto.I-Glycosylation yinyathelo eliphambili ekubunjweni kweebhondi ze-glycosidic, eziyimfuneko ekwakhiweni kwe-carbohydrates kunye ne-glycoconjugates.I-TMS-D-glucose lactone inokuguqulwa ibe ngabaxhasi be-glycosyl, esebenza njengama-intermediates asebenzayo kwiimpendulo ze-glycosylation, eyenza ukuba i-attachment ye-carbohydrates kwezinye ii-molecules.Ngaphezu koko, i-TMS-D-glucose lactone iqeshwe kwimveliso yeepolymers ezisekelwe kwi-carbohydrate.Ngokubeka i-TMS-D-glucose lactone kwi-polymerization reactions, iikhemisti zinokwenza i-polymer chains okanye uthungelwano kunye ne-carbohydrate backbones.Ezi polymers ze-carbohydrate zinokuba neepropati ezizodwa kwaye zinokufumana izicelo kwiindawo ezifana neenkqubo zokuhanjiswa kweziyobisi, i-bioengineering, kunye ne-biomaterials.Kuyafaneleka ukuba uqaphele ukuba i-TMS-D-glucose lactone kufuneka iphathwe ngononophelo ngenxa yokufuma kwayo kunye novakalelo lomoya.Ngokuqhelekileyo igcinwe kwaye iphathwe phantsi kwe-nitrogen okanye i-argon atmospheres ukuthintela ukuthotywa. Isishwankathelo, i-2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (TMS-D-glucose lactone) iyikhompawundi eguquguqukayo esetyenziswa kakhulu Ikhemistri yecarbohydrate.Izicelo zayo eziphambili ziquka ukukhusela i-chemistry yeqela, i-intermediate synthesis, i-glycosyl donor formation, kunye nokuveliswa kweepolymers ezisekelwe kwi-carbohydrate.Ngokusebenzisa i-TMS-D-glucose lactone kwezi nkqubo, iikhemisti zinokufezekisa ulawulo olungcono malunga neempendulo ze-carbohydrate kwaye zenze iintlobo ezahlukeneyo ze-carbohydrate ephuma kuzo kunye nokusetyenziswa okunokwenzeka kwiinkalo ezahlukeneyo.