Iimveliso

(2S,5S)-5-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1 -hi]indole-2-carboxylic acid, masiyibhekise kuyo njengeCompound X, yimolekyuli yendalo entsonkothileyo enezicelo ezinokubakho kwicandelo lemichiza yamayeza kunye nokufunyanwa kweziyobisi.Ubume bayo obukhethekileyo budibanisa i-azepine, indole, kunye ne-fluorene moieties, enika amathuba emisebenzi eyahlukeneyo yezinto eziphilayo kunye nezicelo zonyango.I-Compound X inamaqela amaninzi asebenzayo, kuquka neqela le-carbonyl kunye neqela le-amide.La maqela avumela unxibelelwano olunokwenzeka kunye neethagethi zebhayoloji.Ikhompawundi inokusebenza njengesiqalo sokudityaniswa kunye nokulungiswa kweekhompawundi ezikhokelayo kwiinkqubo zokufunyanwa kweziyobisi.Enye yesicelo esinokubakho seCompound X silele kwiipropati zayo zokulwa ne-antimicrobial.Ubukho beqela le-fluorene, elaziwa ngomsebenzi walo wokulwa ne-antimicrobial, licebisa ukuba le khompawundi inokuthintela ukukhula kweentlobo zentsholongwane ezibangela izifo ezifana neebhaktheriya, umngundo, okanye iiparasite.Ngokuguqula isakhiwo seCompound X, izazinzulu ziyakwazi ukulungelelanisa iimpawu zayo ze-antimicrobial kunye nokuphucula ukukhetha kwayo kwiintsholongwane ezithile.Ngaphezu koko, isakhiwo esikhethekileyo seCompound X singenza ukuba ube ngumviwa onokuthi uphuhlise i-anticancer drug.Iikhompawundi ezisekwe kwi-Indole zibonise umsebenzi ngokuchasene neentlobo ezahlukeneyo zomhlaza, zisebenza njengee-inhibitors zeendlela ezithile zokubonisa ezibandakanyekayo ekwandeni kweeseli zomhlaza kunye nokusinda.Ukongezwa kwe-azepine kunye ne-fluorene moieties kwi-Compound X kunokuphucula ukusebenza kwayo kunye nokukhetha njenge-agent ye-anticancer.Abaphandi banokuphonononga amandla e-Compound X njengekhompawundi ekhokelayo kwaye baphuhlise i-derivatives ebonisa ukuphuculwa komsebenzi we-anticancer kunye nokunciphisa ubuthi.I-fluorene kunye ne-azepine moieties ibonise iimpawu ze-neuroprotective kuphando lwangaphambili.Ulwakhiwo lwale khompawundi luyenza ibe ngumgqatswa onomdla wokuphononongwa ngakumbi ekunyangeni izifo ze-neurodeergenerative, ezifana ne-Alzheimer's okanye isifo sikaParkinson.Ngokuqonda iindlela zesenzo kunye nokuguqula i-Compound X ngokufanelekileyo, abaphandi banokukwazi ukuphuhlisa ukungenelela kwonyango ukukhusela okanye ukucotha ukuqhubela phambili kwezi zifo eziphazamisayo. -yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid, okanye iCompound X, ibambe amandla amakhulu kwinkalo yekhemistri yamayeza kunye nokufunyanwa kweziyobisi.Isakhiwo sayo esikhethekileyo se-molekyuli sibonelela ngamathuba okuphuhliswa kwee-antimicrobial agents, iziyobisi ze-anticancer, kunye ne-neuroprotective compounds.Uphando olongezelelweyo, ukuguqulwa, kunye nokwenza ngcono iCompound X inokutyhila amandla ayo onyango apheleleyo, ekhokelela kuphuhliso lwamachiza amatsha okunyanga izifo ezahlukeneyo.