Iimveliso

I-3-Methyl-7- (2-butyn-1-yl) -8-bromoxanthine yikhemikhali yekhemikhali yentsapho ye-xanthine.I-Xanthine derivatives ifundwe ngokubanzi kwaye iyaziwa ngoluhlu lwazo oluhlukeneyo lwezicelo, ngokukodwa kwintsimi ye-pharmacology.Enye isicelo esibalulekileyo se-3-Methyl-7- (2-butyn-1-yl) -8-bromoxanthine kukusetyenziswa kwayo. njengechiza lokunyanga iimeko zokuphefumla ezifana ne-asthma kunye nesifo esingapheliyo se-pulmonary obstructive (COPD).I-Xanthine derivatives, kubandakanywa ne-theophylline, kudala isetyenziswa kumayeza okuphefumla ngenxa yeempawu zabo ze-bronchodilatory kunye ne-anti-inflammatory.Ezi zixhobo zisebenza ngokukhulula imisipha epholileyo kwi-airways kunye nokunciphisa ukuvuvukala, ngaloo ndlela kuphuculwe umsebenzi wokuphefumula. -8-bromoxanthine inokuphucula iziphumo zayo ze-bronchodilatory xa kuthelekiswa nezinye izinto eziphuma kwi-xanthine.Ukutshintshwa kwe-Bromine kwiikhompawundi ezifanayo kuye kwaboniswa ukwandisa amandla abo kunye nobude besenzo.Ngoko ke, le ngqungquthela inokuba namandla njenge-bronchodilator esebenzayo kwaye ihlala ixesha elide kwiimeko zokuphefumula.Ngaphezu koko, i-xanthines nayo iphandwe ngeempawu zabo ze-neuroprotective.Baye babonisa i-antioxidant kunye ne-anti-inflammatory effects, kunye nokukwazi ukunyusa ukuhamba kwegazi kwi-cerebral kunye nokuphucula umsebenzi wokuqonda.Ezi zakhiwo zibenza babe ngabaviwa abanomdla kwiingxaki ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson's disease.Ukongezelela kwizicelo zamachiza, i-3-Methyl-7- (2-butyn-1-yl) -8-bromoxanthine inokufumana ukusetyenziswa kuphando lwezesayensi.I-Xanthine derivatives ihlala isetyenziswa njengezixhobo ze-biochemical ukufunda i-adenosine receptors kunye ne-phosphodiesterase enzymes.Ezi zixhobo zinokuthi zisebenze njenge-ligands ezikhethiweyo okanye i-inhibitors, ezincedisa uphando lweendlela ezithile ze-molecular kunye neendlela. lungisa iipropati zayo kwizicelo ezithile.Iintlobo ezahlukeneyo zeekhemikhali, ezifana nokutshintshwa, ukudibanisa, kunye neempendulo zokudibanisa, zingaqeshwa ukwazisa amaqela asebenzayo okanye ukuguqula isakhiwo esingundoqo.Olu hlengahlengiso lunokuthi luphucule imisebenzi yalo ye-pharmacological okanye luvumele ukuphuhliswa kwezinto eziphuma kuzo ngokukhetha okuphuculweyo kunye ne-bioavailability.Ekuqukumbeleni, i-3-Methyl-7- (2-butyn-1-yl) -8-bromoxanthine ibambe amandla amakhulu okusetyenziswa kunyango lokuphefumula. , i-neuroprotection, kunye nophando lwe-biochemical.Iziphumo zayo ze-bronchodilatory ziyenza ibe ngumviwa othembisayo wonyango lwezimo zokuphefumla, kunye neempawu zayo ezinokuthi zikhuseleke kwi-neuroprotectors zibonisa izicelo kwizifo ze-neurodeergenerative.Uphando olongezelelweyo kunye nophuhliso luya kufuneka ukuhlola ngokupheleleyo kunye nokuxhaphaza iinzuzo zale khompawundi kwiinkalo ezahlukeneyo zonyango nezenzululwazi.