Iimveliso

I-3-tert-Butoxycarbonylphenylboronic acid, eyaziwa ngokuba yi-Boc-phenylboronic acid, yinto ebalulekileyo ye-boronic acid derivative kunye nezicelo ezibalulekileyo kwi-organic synthesis kunye ne-chemistry yamayeza.Enye yezinto eziphambili zokusetyenziswa kwe-3-tert-Butoxycarbonylphenylboronic acid njengeqela elikhuselayo kwi-organic udibaniso.Iqela le-tert-butyloxycarbonyl (BOC) liqhele ukuqeshwa ukukhusela okwethutyana amaqela asebenzayo e-amine ngexesha lokusabela okwahlukeneyo.Ngokudibanisa iqela le-BOC kwi-amine moiety, i-reactivity ye-amine iyancipha, ivumela ukusabela okukhethiweyo kwezinye izikhundla kwi-molecule.Iqela le-BOC linokususwa ngokulula phantsi kweemeko ezithambileyo, ngaloo ndlela libonisa umsebenzi wokuqala we-amine.Esi sicwangciso seqela esikhuselayo senza ukuba kuhlanganiswe ngokufanelekileyo iimolekyuli ze-organic complex, ezifana namayeza kunye neemveliso zendalo.Ngaphezu koko, i-3-tert-Butoxycarbonylphenylboronic acid isebenza njenge-reagent exabisekileyo yokwenza i-carbon-carbon bond bond.I-Boronic acids, kuquka i-Boc-phenylboronic acid, yenza ngokukhawuleza i-boronate esters xa isabela nge-nucleophiles, njenge-alcohols okanye i-amines.Ezi esters ze-boronate zinokuthi ke zingene kwiinguqu ezahlukeneyo, ezibandakanya ukuhlangana kwe-Suzuki-Miyaura, ukudityaniswa kwe-Negishi, kunye ne-Stille couplings.Ezi ntshukumo zenza ukuba kuvele iimolekyuli ezintsonkothileyo zezinto eziphilayo ezineepateni ezahlukeneyo zokutshintsha kunye namaqela asebenzayo.I-Boc-phenylboronic acid iluncedo kakhulu ekuziseni i-phenylboronic acid moiety kwiimolekyuli ezijoliswe kuyo.Ukwengeza, i-Boc-phenylboronic acid idlala indima ebalulekileyo kwi-chemistry yamayeza.Ukusebenza kwe-boronic acid kunokukhetha ukusebenzisana kunye ne-diols okanye i-boronate ester-sensitive esebenzayo amaqela kwiithagethi zebhayoloji, eyenza ukuyila i-boronate-based enzyme inhibitors kunye ne-receptor ligands.I-Boc-phenylboronic acid inokudityaniswa kwi-inhibitors encinci ye-molecule, i-peptides, okanye i-prodrugs ukunika iimpawu ezinqwenelekayo okanye ukuphucula ukucaciswa okujoliswe kuyo.Ezi zixhobo ezisekelwe kwi-boronate zibonise isithembiso kunyango lwezifo ezahlukahlukeneyo, kubandakanywa umhlaza, isifo sikashukela, kunye nokuvuvukala.Ngokufutshane, i-3-tert-Butoxycarbonylphenylboronic acid, okanye i-Boc-phenylboronic acid, ifumana izicelo ezahlukeneyo kwi-organic synthesis kunye ne-chemistry yamayeza.Iqela layo le-BOC lisebenza njengeqela elikhuselayo, livumela ukuphendula okukhethiweyo kwezinye izikhundla kwi-molecule.Ngapha koko, ukusebenza kwe-asidi ye-boronic kwenza ukuba i-carbon-carbon bond formations, iququzelele ukuhlanganiswa kweemolekyuli zezinto eziphilayo.Ukongezelela, i-Boc-phenylboronic acid idlala indima ebalulekileyo kwi-chemistry yamayeza, apho isetyenziselwa ukuyila i-boronate-based enzyme inhibitors kunye ne-receptor ligands.Ngokubanzi, i-Boc-phenylboronic acid yi-reagent exabisekileyo enegalelo kwinkqubela phambili kwi-synthetic chemistry kunye nophando lokufumanisa iziyobisi.