Iimveliso

I-3,4,5-Trifluorophenylboronic acid yikhemikhali yekhemikhali kunye nezicelo kwiinkalo ezahlukeneyo, kuquka i-organic synthesis, i-chemistry yamayeza, kunye nesayensi yezinto.Le khompawundi ithathwe kwibenzene, ineathom ezintathu zefluorine (-F) kunye neqela elisebenzayo le-boronic acid (-B(OH)2) encanyathiselwe kwizikhundla 3, 4, kunye ne-5 yeringi yephenyl.Onye yosetyenziso oluphambili lwe-3 ,4,5-Trifluorophenylboronic acid ifana nebhloko yokwakha eguquguqukayo kwi-organic synthesis.Iqela le-asidi ye-boronic linokuthi liqhube ngeendlela ezahlukeneyo zokuphendula, ezifana ne-Suzuki-Miyaura-cross-coupling reactions, eyenza ukubunjwa kweebhondi ze-carbon-carbon.Ezi mpendulo zisetyenziswa ngokubanzi ekudityanisweni kweemolekyuli zendalo ezintsonkothileyo, kubandakanywa amayeza, iikhemikhali zezolimo, kunye neekhemikhali ezikhethekileyo.Ngokudibanisa i-3,4,5-Trifluorophenylboronic acid kwi-reaction, i-chemist inokwazisa iqela le-trifluoromethyl kwindawo efunwayo, enokuthi ichaphazele kakhulu i-compound's chemicals and biological properties.Kwikhemikhali yonyango, i-3,4,5-Trifluorophenylboronic acid iyasebenza. kuphuhliso lwabagqatswa abatsha bamachiza.Ubukho beqela le-trifluoromethyl bunokuphucula i-lipophilicity yekhompawundi, uzinzo lwe-metabolic, kunye neprotheyini ebophelelayo, iyenze ibe sisixhobo esixabisekileyo sokuguqula iimpawu zechiza.Ukongeza, i-boronic acids ibonise umsebenzi ngokuchasene nezifo ezinjengomhlaza, isifo sikashukela, kunye nokuphazamiseka kokudumba.Ngokubandakanya i-trifluorophenylboronic acid motif, abaphandi banokwenza iikhompawundi zenoveli eziphethe i-boronic acid kunye ne-trifluoromethyl pharmacophores, ezinokukhokelela ekuphuculeni ukusebenza kunye nokukhetha kwiiprojekthi zokufumanisa iziyobisi.Ngaphezu koko, iimpawu ezizodwa ze-3,4,5-Trifluorophenylboronic acid zenza ukuba luncedo. kwizixhobo zokusebenza zesayensi.Iqela le-trifluoromethyl indalo yokutsalwa kwe-electron inokuphembelela uzinzo lwekhompawundi kunye nokusebenza kwakhona.Olu phawu lwenza ukuba ikhompawundi ithathe inxaxheba kwiimpendulo ezahlukeneyo zepolymerization, ekhokelela ekwakhiweni kweepolymers ezikhethekileyo ezineempawu ezongeziweyo, ezinjengozinzo olongezelelekileyo lobushushu okanye ukuncamathela okuphuculweyo.Ukongezelela, ikhono leqela le-boronic acid ukwenza intsebenziswano eguqulwayo kunye ne-diols okanye i-boronic esters ingasetyenziselwa ukuyila izinto eziphendulayo, ezifana ne-hydrogel, izinto zokuva, kunye neenkqubo zokuhanjiswa kweziyobisi.Xa usebenza ne-3,4,5-Trifluorophenylboronic acid, ukuphathwa ngokufanelekileyo kunye namanyathelo okhuseleko kufuneka athathwe.Le khompawundi inovelwano kumoya nokufuma, kwaye kufuneka igcinwe kwindawo epholileyo neyomileyo.Izixhobo zokukhusela zomntu, ezinjengeeglavu kunye nezibuko, kufuneka zigqitywe, kwaye iindawo zokusebenza kufuneka zingene ngokufanelekileyo.Ekuqukumbeleni, i-3,4,5-Trifluorophenylboronic acid iyingqungquthela ebalulekileyo kwiinkalo ezahlukeneyo zesayensi.I-trifluoromethyl yayo kunye namaqela asebenzayo e-boronic acid ayenza ibe yinto eguquguqukayo yokwakha i-organic synthesis, eyenza ukubandakanywa kweempawu ezizodwa kwiimolekyuli ezijoliswe kuyo.Ukusetyenziswa kwayo kwikhemistri yezamayeza kunye nenzululwazi yezixhobo iqaqambisa amandla ayo okufunyanwa kweziyobisi kunye nophuhliso lwemathiriyeli ephezulu.Ngokuqhubeka nokuphonononga iipropati kunye ne-reactivity ye-3,4,5-Trifluorophenylboronic acid, abaphandi banokufumanisa izicelo ezintsha ezifaka isandla kwinkqubela phambili kwiinkalo ezininzi.