Iimveliso

(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, ekwabizwa ngokuba yi-compound BISO, yi-chemical compound ene- Ulwakhiwo olulodwa oluziboleka kusetyenziso oluninzi olunokubakho kwicandelo lemichiza yamayeza kunye nophuhliso lwamachiza.Enye isicelo esinokubakho se-BISO kunyango lweengxaki zemithambo-luvo.Ubukho be-benzo [d] isothiazol-3-yl moiety kwisakhiwo sayo bucebisa ukuba i-BISO inokuba nokusebenzisana kunye neenkqubo ezithile ze-neurotransmitter kwingqondo, njenge-glutamate okanye iinkqubo ze-GABAergic.Ezi nkqubo ze-neurotransmitter zichaphazeleka kwiingxaki ezininzi ze-neurological ezifana nokuxhuzula, ixhala, kunye nokuphazamiseka kweemvakalelo.Abaphandi banokuphonononga ukubanakho kwe-BISO ukumodareyitha ezi nkqubo kunye nokuphuhlisa ii-arhente zonyango ezinoveli kwiimeko ze-neurological. iithagethi zebhayoloji.Ubume bayo obuthathu kunye nobukho bamaqela asebenzayo banokusebenzisana kunye ne-receptors ethile okanye i-enzymes, evumela ukuyila amayeza akhethiweyo kunye namandla.Abaphandi banokusebenzisa le motif yesakhiwo ukuphuhlisa iamolekyu ezincinci ezijolise kwi-receptors ezibandakanyekayo kwizifo ezahlukahlukeneyo, ezifana nomhlaza, ukuphazamiseka kwentliziyo, okanye izifo ezithathelwanayo.Ngaphezu koko, isakhiwo se-spirocyclic se-BISO kunye neqela elihlawuliswayo le-ammonium zenza ukuba ube ngumviwa onokwenzeka kwiinkqubo zokuhanjiswa kweziyobisi.Ubukho beqela elihlawulisiweyo livumela ukubunjwa kwee-ionic complexes kunye neemolekyuli ezihlawuliswa kakubi, ezifana ne-nucleic acids okanye iiprotheni.Ezi zintsonkothileyo zinokuququzelela ukuhanjiswa okujoliswe kuko kweeamolekyu ze-bioactive kwiiseli okanye izicubu ezithile, ukuphucula ukusebenza konyango ngelixa kuncitshiswa iziphumo ebezingalindelekanga zenkqubo.Kuyafuneka ukuba kuqatshelwe ukuba izicelo ezinokwenzeka ze-BISO ziyaqikelelwa kwaye zifuna uphando olongezelelweyo kunye nophuhliso.Ubume bayo obukhethekileyo bunikezela ngamathuba kwiikhemisti zamayeza ukuba baphonononge iipropati zayo ze-pharmacological kunye nokwandisa amandla ayo okufumana ichiza.Njengazo naziphi na iikhompawundi zeekhemikhali, ukusetyenziswa kwe-BISO kufuneka kuhambelane nemigaqo yokhuseleko kunye nezikhokelo.Abaphandi kufuneka balumke ngexesha lokudibanisa, ukuphatha, kunye nokugcinwa kwayo ukuqinisekisa ukhuseleko kunye nokunciphisa ingozi. ]-2-ium4-methylbenzenesulfonate, okanye i-BISO, ibambe isithembiso sezicelo ezahlukeneyo kwikhemikhali yamayeza kunye nophuhliso lwamachiza.Isakhiwo sayo esikhethekileyo sibonelela ngamathuba okufunyanwa kwee-agent ezintsha zonyango, iinkqubo ezijoliswe kuzo zokuhanjiswa kweziyobisi, kunye nokuguqulwa kweenkqubo ze-neurotransmitter.Nangona kunjalo, uphando olubanzi luyimfuneko ukucacisa ngokupheleleyo amandla alo kunye nokwandisa ukusetyenziswa kwayo kwintsimi yeyeza.