Iimveliso

(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one,ekwaziwa ngokuba yi-TBDMS-protected tetrahydro-2H-pyran -2-enye, i-compound esetyenziswa ngokuqhelekileyo kwi-organic synthesis kunye neqela elikhuselayo kwintsimi ye-chemistry.Enye isicelo esibalulekileyo se-TBDMS-ekhuselweyo ye-tetrahydro-2H-pyran-2-enye kukusetyenziswa kwayo njengebhloko yokwakha kwi-synthesis. yeemolekyuli ezintsonkothileyo zezinto eziphilayo.Ikhompawundi ineendawo ezininzi ezisebenzayo ezinokungena kwiinguqu ezahlukeneyo zeqela elisebenzayo.I-TBDMS (i-tert-butyldimethylsilyl) iqela elikhuselayo elikhoyo kwi-molecule linika uzinzo kwaye livumela ukuguqulwa okukhethiweyo kwamaqela athile asebenzayo.Oku kuguquguquka kwenza ukuba i-TBDMS-ekhuselweyo i-tetrahydro-2H-pyran-2-enye ibe yindawo exabisekileyo ephakathi kwi-synthesis yeemveliso zendalo, amayeza, kunye nezinye iikhemikhali ezintle. Indima njengeqela elikhuselayo lotywala kunye neeamines kwi-organic synthesis.Iqela le-TBDMS linokongezwa ngokukhethiweyo kumaqela e-hydroxyl okanye e-amino, ukuwafihla ngokufanelekileyo ngexesha lamanyathelo okusabela ahlukeneyo.Olu khuselo luthintela ukusabela okungafunekiyo kwaye luqinisekisa ukuba utshintsho olufunekayo lwenzeka kwiindawo ezifunwayo.Emva kokuba iimpendulo ezifunwayo zigqityiwe, iqela le-TBDMS lingasuswa ngokulula, libonise i-hydroxyl yokuqala okanye iqela le-amino ngaphandle kokuchaphazela ezinye izinto ezisebenzayo kwi-molecule.I-TBDMS-ekhuselweyo ye-tetrahydro-2H-pyran-2-enye iphinda ifumane isicelo njenge-agent ekhuselayo. iicarbohydrates.Ivumela ukukhuselwa okukhethiweyo kwamaqela e-hydroxyl kwiimolekyuli zeswekile ngexesha lokuphendula kwe-glycosylation, eyenza ukuhlanganiswa kwee-glycans eziyinkimbinkimbi kunye ne-glycosides.Esi sicwangciso sokukhusela sibaluleke kakhulu kwi-carbohydrate chemistry, apho amaqela amaninzi e-hydroxyl ekhoyo kwaye i-regioselectivity ethile iyadingeka.Ngaphezu koko, i-TBDMS-ekhuselweyo ye-tetrahydro-2H-pyran-2-one isetyenziselwa ukulungiswa kweepolymers ezisebenzayo.Ikhompawundi inokudityaniswa kwizakhiwo zepolymer, ibonelela ngeendawo ezisebenzayo zohlengahlengiso olongezelelweyo kunye neempendulo ezidibanisayo.Oku kuvumela ukudalwa kwezixhobo zepolymer ezineempawu ezilungiselelwe kunye nokusebenza, ezifana nokuzinza okuphuculweyo, ukuhambelana kwezinto eziphilayo, kunye nokukhululwa kweziyobisi ezilawulwayo. Ekugqibeleni, (3R, 4S, 5R, 6R) -3,4,5-tris (triMethylsilyloxy) -6 -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, okanye i-TBDMS-ekhuselweyo i-tetrahydro-2H-pyran-2-enye, i-compound eguquguqukayo kunye nezicelo ezahlukeneyo kwi-organic synthesis, ngakumbi njengebhloko yokwakha kunye neqela elikhuselayo. .Ikhono layo lokukhusela ngokukhethekileyo amaqela asebenzayo kunye nokuququzelela ukuguqulwa kweemolekyuli ezinzima kwenza kube sisixhobo esibalulekileyo kwintsimi ye-chemistry.Uphando oluqhubekayo kunye nokuphononongwa kwezicelo zalo kunokufumanisa ukusetyenziswa okungaphezulu kwaye kube negalelo kwinkqubela phambili ye-synthetic chemistry kunye nesayensi yezinto.