I-4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 Ikhaphukhaphu emthubi ukuya kwi-amber ukuya kumgubo omnyama oluhlaza ukuya kwintlama
| Inombolo Yekhathalogu | XD90156 |
| Igama lemveliso | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Ifomula yeemolekyuli | C8H7N3O2 |
| Ubunzima beMolekyuli | 177.16 |
| Iinkcukacha zokuGcina | Gcina eRT |
Ukucaciswa kweMveliso
| Imbonakalo | Umthubi okhanyayo ukuya kwi-amber ukuya kumgubo oluhlaza omnyama ukuya kwiqhuma |
| uAsay | ≥98.0% |
| Ukuxinana | 1.433 |
| Indawo yokunyibilika | 300 ºC |
| Indawo yokubilisa | 633°C ku-760 mmHg |
| Indawo yokuflasha | 336.7°C |
| Ukunyibilika | Inyibilika kwi-ammonium hydroxide, i-sodium carbonate okanye esinye isiseko. |
1.Sihlalutye kwaye sithelekisa umphumo we-H1-antihistamines ezintlanu kwi-stimulated burst oxidative kwinqanaba elingaphezulu kunye ne-intracellular ye-polymorphonuclear leukocytes yabantu ababodwa kunye nokuvuselela i-polymorphonuclear leukocytes.Ukuqhuma kwe-Oxidative ye-neutrophils yabantu eyedwa yafundwa nge-luminol kunye ne-isoluminol ephuculweyo ye-chemiluminescence. I-rank order of potency ye-H1-antihistamines ukunciphisa i-chemiluminescence yavavanywa ngaphandle kwe-extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine kunye nesayithi ye-intracellular: loratadine> dithiaden.H1-antihistamines yahluke kakhulu ngokuhambelana ne-chemicals ye-extrapressing ye-extra. - kunye nendawo ye-intracellular ye-neutrophils yabantu ekhuthazwayo yodwa.
Iinkqubo ze-2.Chemiluminescence eziphuculwe yi-isoluminol okanye i-luminol ngokudibanisa ne-peroxidase ziindlela ezinovakalelo zokubona iintlobo ze-oxygen esebenzayo (ROS) eyenziwa yi-phagocyte NADPH oxidase.Ii-substrates ezimbini ezikhulisayo zifana kakhulu ngokwesakhiwo, zahluke kuphela kwindawo yeqela le-amino kwiringi elivumba leemolekyuli.Lo mahluko wenza i-isoluminol ibe yi-molecule encinci ye-lipophilic engakwazi ukungena kwiinwebu zebhayoloji.Ukusetyenziswa kwe-isoluminol ngenxa yoko kuthintelwe kwizifundo ezijongene nokukhuselwa kwe-oxygen metabolites.Kolu phononongo sibonisa ukuba i-peptides yokwenziwa ephuma kwi-N-terminal domain ye-calcium-regulated protein annexin AI iphazamisa ukufunyanwa kwe-radicals kwi-isoluminol-amplified, kodwa kungekhona kwi-luminol-amplified, inkqubo.I-annexin AI-derived peptides inciphisa ukuphuma kokukhanya nge-isoluminol echulumanciswe yi-superoxide kunye ne-horseradish peroxidase (HRP) kwi-formyl-methionyl-leucyl-phenylalanine- kunye ne-phorbol iiseli zam ze-ristate acetate-stimulated, kunye ne-hydrogen peroxide kunye ne-HRP.Indlela echanekileyo yokuthintela ayaziwa.Iziphumo ezinikezelweyo zicebisa ngamandla ukuba impendulo encitshisiweyo yeselula efunyenwe nge-isoluminol-amplified chemiluminescence kufuneka iqinisekiswe ngenye indlela yokumisela ukukhutshwa kwe-anion ye-superoxide kunye ne-hydrogen peroxide.
