Iimveliso

I-4-Chloro-2-fluoro-3-methoxyphenylboronic acid yikhemikhali enezicelo ezahlukeneyo kwi-organic synthesis, i-chemistry yamayeza, kunye nesayensi yezinto. kwinguqu yesinyithi-catalyzed cross-coupling reactions.Isebenza njengebhloko yokwakha i-boronic acid, evumela ukubunjwa kwe-carbon-carbon okanye i-carbon-heteroatom bonds.Ngokomzekelo, le khompawundi ingasetyenziswa kwi-Suzuki-Miyaura-cross-coupling reactions, apho isabela nge-aryl okanye i-vinyl halides phantsi kwe-palladium catalysis ukuvelisa i-biaryl compounds.Ezi mpendulo zokudibanisa zisetyenziswa ngokubanzi kwi-synthesis ye-molecule eyinkimbinkimbi yezinto eziphilayo, kubandakanywa amayeza kunye ne-agrochemicals, kunye nokwakhiwa kwezinto eziphilayo.Inhlanganisela ekhethekileyo ye-chlorine, i-fluorine, kunye namaqela e-methoxy kwisakhiwo se-4-Chloro-2 -i-fluoro-3-methoxyphenylboronic acid yenza ukuhlanganiswa kwezinto eziphuma kuzo ezahlukeneyo ezineempawu ezilungiselelwe.I-athomu yeklorini inokusebenza njengeqela eliqondisayo kwiinkqubo zenguqu zetsimbi-catalyzed, ziqondise ukuphendula ngokukhethiweyo kwiindawo ezithile ngaphakathi kwe-molecule.Ukutshintshwa kwe-fluorine kubonelela nge-lipophilicity eyongeziweyo, enokuthi ibe nefuthe kwiimpawu zekhemisikhinetic zekhompawundi kunye nokuphucula ukufumaneka kwayo kwe-bioavailability.Iqela le-methoxy, ngakolunye uhlangothi, lingenza njengeqela elikhuselayo okanye lithathe inxaxheba kwiinguqu ezahlukeneyo zeekhemikhali.Kwikhemikhali yamayeza, i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid kunye ne-derivatives yayo inomdla njengabaviwa beziyobisi.Amaqela asebenzayo afana neklorini kunye ne-fluorine anokulungelelanisa intsebenziswano yekhompawundi kunye neethagethi zebhayoloji kunye nokuphucula iimpawu zayo ze-pharmacological.Ukongeza, iqela le-methoxy linokuphucula uzinzo lwe-metabolic yekhompawundi kwaye libe negalelo kwi-lipophilicity kunye nokunyibilika.Ezi zakhiwo zenza i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid ibe yindawo yokuqala exabisekileyo ekuphuhliseni ii-agent ezintsha zonyango kwiinkalo ezifana ne-oncology, izifo ezosulelayo kunye nokuvuvukala.Ngaphezu koko, i-boronic acid moiety kwi-4-Chloro-2-fluoro. -I-3-methoxyphenylboronic acid inokwenza ukubunjwa kwe-boronate esters ezinzile, eziye zasetyenziswa ekuyilweni kwezinto ezineempawu ezizodwa.Ezi zixhobo zinokubonisa i-optical, i-electronic, okanye i-catalytic properties, kuxhomekeke ekubunjweni kwayo kunye nokwakheka.Ukudityaniswa kwe-4-Chloro-2-fluoro-3-methoxyphenylboronic acid okanye i-derivatives yayo kwezi zinto inokunika imisebenzi ethile kunye nokuphucula ukusebenza kwazo.Ngokufutshane, i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid ifumana izicelo kwiinkalo ezahlukeneyo. ngenxa ye-chemistry yayo eguquguqukayo kunye namandla okwenza iimolekyuli ezisebenzayo kunye nezixhobo.Indima yayo kwinguqu ye-metal-catalyzed coupling reactions, idibaniswe neempawu ezizodwa zamaqela ayo asebenzayo, yenza ukuba ibe sisixhobo esibalulekileyo kwi-organic synthesis kunye ne-chemistry yamayeza.Ukongezelela, i-boronic acid moiety yenza ukuba kuqulunqwe i-boronate esters, enegalelo ekuphuhlisweni kwezinto eziphambili ezineempawu ezilungiselelwe.