Iimveliso

I-4,5,6,7-Tetrahydrothieno [3,2,c] i-pyridine hydrochloride, eyaziwa nangokuthi i-THP hydrochloride, i-chemical compound kunye ne-molecular formula C8H11NS·HCl.Ingumgubo omhlophe we-crystalline osetyenziswa ngokuqhelekileyo kwi-organic synthesis kunye nophando lwamachiza.Enye yezicelo eziphambili ze-4,5,6,7-Tetrahydrothieno [3,2, c] i-pyridine hydrochloride ifana nebhloko yokwakha eguquguqukayo kwi-synthesis. yeekhompawundi ezahlukeneyo eziphilayo.Iqulethe i-thienopyridine core, enika isakhiwo esikhethekileyo sokwakhiwa kweeamolekyu ezinzima.I-thienopyridine motif inokukhethwa ngokusebenzayo, ivumela ukuqaliswa kwamaqela ahlukeneyo asebenzayo ukuguqula iipropati kunye nokuphinda kusebenze i-compounds ebangelwayo.4,5,6,7-Tetrahydrothieno [3,2, c] pyridine hydrochloride isakhiwo sikwenza kubalulekile phakathi ekudityanisweni kwamayeza amaninzi.Ngokomzekelo, inokusetyenziswa ekulungiseleleni iziyobisi ze-antipsychotic, ezifana ne-clozapine kunye ne-olanzapine, ezisetyenziswa ngokuqhelekileyo kunyango lwe-schizophrenia kunye ne-bipolar disorder.Ikhompawundi ingaphinda isetyenziswe kwi-synthesis yezinye ii-agent zonyango, ezibandakanya i-analgesics, i-anti-inflammatories, kunye neziyobisi ezichasayo.Ngaphezu koko, i-4,5,6,7-Tetrahydrothieno [3,2, c] pyridine hydrochloride inokusebenza njenge-precursor. ukwenzela ukuhlanganiswa kweeathom zebhayoloji ezisebenzayo.Ngokuguqula i-substituents kwindandatho ye-thienopyridine, izazinzulu ziyakwazi ukulungelelanisa iikhompawundi ezibangelwa ukujolisa kwiindlela ezithile zebhayoloji okanye i-receptors.Oku kuguquguquka kwesakhiwo kwenza kube sisixhobo esibalulekileyo ekufumaneni iziyobisi kunye nophuhliso.Omnye umba obalulekileyo we-4,5,6,7-Tetrahydrothieno[3,2,c]pyridine hydrochloride kukukwazi ukusebenza njengeqela elikhuselayo kumaqela asebenzayo abuthathaka ngexesha. ukuphendula kweekhemikhali.I-THP moiety inokwaziswa ngokulula kwaye emva koko isuswe phantsi kweemeko ezithambileyo, ukuvumela ukukhuselwa kwamaqela asebenzayo asemngciphekweni ngelixa ezinye iimpendulo zisenzeka.Olu phawu luluncedo ngokukhethekileyo kwi-organic synthesis, eyenza ukuguqulwa okukhethiweyo kweemolekyuli ezinzima.Kubalulekile ukuqaphela ukuba ukusetyenziswa okuthe ngqo kwe-4,5,6,7-Tetrahydrothieno[3,2,c]pyridine hydrochloride kuyahluka ngokuxhomekeke kwizinto ezifunwayo. imolekyuli ekujoliswe kuyo kunye neemeko zokusabela.Iikhemisti kufuneka zilumke kwaye zilandele iiprothokholi ezifanelekileyo zokhuseleko xa zibamba kwaye zisebenzisa le khompawundi.Ukongezelela, izikhokelo zokulawula ezingqongqo kufuneka zilandelwe ukuqinisekisa ukusetyenziswa kokuziphatha kunye noxanduva lwale khompawundi kuphando lwamayeza.