Iimveliso

(4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol -1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate i-compound ene-chemical structure complex.Nangona ulwazi oluthile malunga nokusetyenziswa kwesi sixhobo lunokunciphisa, sinokuxoxa ngezicelo ezinokuthi zisetyenziswe ngokusekelwe kwiimpawu zayo zesakhiwo kunye neempawu eziqhelekileyo ze-compounds ezifanayo.Ubukho be-dioxane moiety kule ngqungquthela ibonisa ukuba ingaba neepropati ze-solvent okanye isetyenziswe. njenge arhente solubilizing.I-Dioxane yi-solvent eqhelekileyo, ngokukodwa kwi-organic chemistry, njengoko i-water-miscible kwaye ine-solubility efanelekileyo kwiindidi ezininzi ze-organic molecule.Ubukho be-dioxane moiety kule khompawundi bubonisa ukuba ingaba neepropati ezifanayo zokunyibilika.Ngaphezu koko, amacandelo esakhiwo sale khompawundi, njengamaqela e-fluorophenyl kunye ne-phenylamino carbonyl, acebisa umsebenzi onokubakho webhayoloji.Ukutshintshwa kwe-fluorine kwiikhompawundi ze-organic kunokuphucula iimpawu zabo ze-pharmacokinetic, ezinokwandisa amandla abo okanye i-bioavailability.Ubukho beqela le-phenylamino carbonyl lingabonisa amandla entsebenziswano kunye neethagethi zezinto eziphilayo, ezinokuthi zikhokelela kwimiphumo yokwelapha.Ngokusekelwe kwezi mpawu zesakhiwo, kunokwenzeka ukuba le ngqungquthela ingaba nezicelo kwi-chemistry yamayeza okanye uphuhliso lweziyobisi.Inokuphononongwa njengekhompawundi enokubakho ekhokelela kuphuhliso lwamachiza amatsha ajolise kwizifo ezithile.Nangona kunjalo, kubalulekile ukuqaphela ukuba uphando olongezelelweyo luyafuneka ukugqiba iimpawu zayo ze-pharmacological, kubandakanywa nokusebenza kwayo, indlela yokusebenza, kunye nemiphumo enokubakho. okanye njengenxalenye kwi-chemical synthesis.I-Nitronyl kunye ne-pyrrole derivatives ziye zaphandwa ukuze zisetyenziswe njengabaqhubi be-organic, i-catalysts, okanye iibhloko zokwakha zezakhiwo ezinzima ngakumbi.Nangona kunjalo, ezi zicelo ziza kufuna uphando olongezelelweyo kunye nokulungiswa kweendlela zokudibanisa. Ngokubanzi, i-compound (4R-Cis) -1,1-Dimethylethyl-6--[2-(4-fluorophenyl) -5-(1-) i-methylethyl) -3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate ibonisa amandla okusetyenziswa kwi-chemistry yamayeza, isayensi yezinto, okanye ikhemikhali synthesis.Nangona kunjalo, kubalulekile ukwenza uphando olubanzi ukuvavanya iipropathi zayo, ukuphuhlisa iindlela ezifanelekileyo zokudibanisa, kunye nokumisela usetyenziso oluthile kwinkalo nganye.