Iimveliso

I-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole yikhemikhali yekhemikhali ephethe amandla abalulekileyo kwizicelo ezahlukeneyo zonyango.Le ngqungquthela iyingxenye yeklasi ye-benzimidazole derivatives, eyaziwayo ngemisebenzi yabo ye-pharmacological.Enye yezinto eziphawulekayo zokusetyenziswa kwe-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole yindima yayo njenge-anti-cancer agent.I-benzimidazole derivatives ibonise iziphumo ze-cytotoxic ngokuchasene nemigca yeeseli zomhlaza ngokuthintela ukukhula kweeseli kunye nokunyanzeliswa kwe-apoptosis.I-molecular modifications ethile kwi-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole iphucula umsebenzi wayo we-antiticancer, enokuthi ivule iingcango zeendlela zonyango ezinoveli kwi-oncology.Esinye isicelo esinokuthi sisetyenziswe kule khompawundi silele kwiipropati zayo ze-antimicrobial.I-Benzimidazole derivatives ibonise umsebenzi osebenzayo we-antimicrobial ngokuchasene noluhlu olubanzi lwe-microorganisms, kubandakanywa ibhaktheriya, i-fungi kunye ne-parasites.Iimpawu ezikhethekileyo zesakhiwo se-compounds zifaka isandla kwi-antimicrobial potential, okwenza kube ngumgqatswa othembisayo wokulwa ne-pathogens enganyangekiyo ngamachiza kunye nezifo ezithathelwanayo.Ngaphezu koko, i-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole ibonise umsebenzi wokulwa nokuvuvukala.Ukudumba kudlala indima ebalulekileyo kwi-pathogenesis yezifo ezahlukeneyo, kubandakanywa neemeko ezingapheliyo njenge-rheumatoid arthritis kunye nesifo sokukrala kwamathumbu.Iipropati ezichasayo zekhompawundi zenza ukuba ube ngumviwa onokuthi uphuhlise unyango olutsha kwiimeko ezinjalo.Ukwengeza, i-benzimidazole derivatives nayo ihlolwe ngendima yabo enokubakho kwiingxaki zenkqubo ye-nervous central.Iikhompawundi ezithile kule klasi zibonise iziphumo ze-neuroprotective kunye nokukwazi ukuphucula imemori kunye nemisebenzi yokuqonda.Kungenzeka ukuba i-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole ingabonakalisa imiphumo efanayo, iyenze ibe ngumviwa onokuthi uphuhliswe unyango lwezifo ze-neurodeergenerative ezifana ne-Alzheimer's and Parkinson's disease.Nangona kunjalo, kubalulekile ukuqaphela ukuba I-5-(Difluoromethoxy) -2-mercapto-1H-benzimidazole isaphandwa, kwaye uphando olongezelelweyo luyafuneka ukuze kuqinisekiswe amandla ayo onyango, ukhuseleko kunye nezicelo ezifanelekileyo.Kubalulekile ukuba nayiphi na ikhompawundi enokubakho yoxubo lweyeza ukuba ivavanywe ngokungqongqo, kubandakanywa nolingo lwangaphambili kunye novavanyo lweklinikhi, ukuseka ukusebenza kwayo kunye neprofayili yokhuseleko.Kuhlala kubalulekile ukubonisana nabasebenzi bezempilo kunye neengcali kwinkalo yolwazi oluchanekileyo kunye nesikhokelo malunga nokusetyenziswa okuthile. , idosi, kunye neziphumo ebezingalindelekanga ezinokubakho kuyo nayiphi na ikhompawundi yamayeza.