5-Nitro-1,10-phenanthroline CAS:4199-88-6 Ukukhanya tyheli ukuya kwikristale emdaka
| Inombolo Yekhathalogu | XD90385 |
| Igama lemveliso | I-5-Nitro-1,10-phenanthroline |
| CAS | 4199-88-6 |
| Ifomula yeemolekyuli | C12H7N3O2 |
| Ubunzima beMolekyuli | 225.21 |
Ukucaciswa kweMveliso
| Indawo yokunyibilika | 200 - 203 °C |
| Isivavanyi | 99% |
| Imbonakalo | Ubutyheli ukuya kwikristale emdaka |
Iplatinum (II)-based metallointercalators ziye zadityaniswa ezisebenzisa indawo ye-1,10-phenanthroline (phen) ligands, kuquka i-5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) kunye dipyrido[3,2-d :2',3'-f]quinoxaline (dpq), kunye ne-achiral ethylenediamine (en) kunye ne-chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) kunye ne-1R,2R-diaminocyclohexane (R,R-dach) .I-cytotoxicity yabo kwi-L1210 murine leukemia cell line yamiselwa ngokusebenzisa iimvavanyo zokuthintela ukukhula.Ezona zakhiwo zentsimbi ze-cytotoxic zezo ziqulethe i-S,S-dach ancillary ligands kunye ne-5-CH3-phen intercalating ligands.Enye i-metallointercalator [Pt (5-CH3-phen) (S,S-dach)]Cl2 (5MESS), ibonisa ukunyuka kwe-5-10 kwi-cytotoxicity xa kuthelekiswa ne-agent yeklinikhi cisplatin.Ukusuka kwimifuniselo ebophelelayo ye-DNA kubonakala ngathi akukho mahluko ubalulekileyo phakathi kwazo naziphi na izakhiwo zetsimbi, nto leyo ebonisa ukuba akukho DNA ebophelelayo ubudlelwane okanye indlela yokubopha/i-DNA adduct eyenziweyo kuphela kwesimiselo se-cytotoxicity yolu sapho lweplatinam(II)-based. metallointercalators.
