Iimveliso

I-8-Bromo-3-methyl-xanthine, eyaziwa ngokuba yi-8-BMX, i-synthetic compound eyeqela le-xanthines.I-Xanthines ludidi lweekhompawundi ezinokwakheka ezifana necaffeine kwaye zineziphumo ezifanayo emzimbeni.Nangona kunjalo, i-8-BMX ngokukodwa ayisetyenziswanga ngokuqhelekileyo okanye iyaziwa kakhulu xa kuthelekiswa nezinye i-xanthines ezifana ne-caffeine okanye i-theophylline.Enye yezinto eziphambili zokusetyenziswa kwe-8-BMX kuphando lwesayensi njengomchasi okhethiweyo we-adenosine receptors.I-Adenosine yinto eyenzeka ngokwemvelo emzimbeni osebenza njenge-neuromodulator kwaye idlala indima kwiinkqubo ezahlukeneyo ze-physiological, kuquka ukulawulwa kokulala, ukuvuvukala, kunye nomsebenzi we-cardiovascular function.Ngokuthintela i-adenosine receptors, i-8-BMX inokuguqula ezi nkqubo kwaye ibonelele abaphandi ngolwazi oluxabisekileyo malunga nendima ye-adenosine kwiinkqubo ezahlukeneyo.Ngomsebenzi wayo ochasayo kwi-adenosine receptors, i-8-BMX iye yafundelwa imiphumo enokubakho kwi-nervous central. inkqubo.Isetyenziswe kuphando malunga nokuxhalaba, ukudakumba, kunye nezifo ze-neurodeergenerative ezifana ne-Parkinson kunye ne-Alzheimer's.Ngokuthintela i-adenosine receptors, i-8-BMX inokulungelelanisa i-neurotransmission kwaye inokuba nemiphumo yokwelapha kwezi meko.Nangona kunjalo, kufuneka kuqatshelwe ukuba ukusetyenziswa kwe-8-BMX kwezi zifundo kuninzi kuvavanyo kwaye akuzange kuguqulelwe kusetyenziso lwekliniki olubanzi.Ngaphandle kwempembelelo yayo kwinkqubo ye-nervous central, i-8-BMX isetyenziswe kwezinye iindawo zophando. .Ngokomzekelo, isetyenziswe njengesixhobo sokufunda indima ye-adenosine receptors kwi-cardiorespiratory function kunye nokuphanda imiphumo ye-adenosine receptor antagonists kwintliziyo kunye nemiphunga.Ukongezelela, i-8-BMX iphandiwe ngenxa yokukwazi kwayo ukulungelelanisa ukuphendula komzimba kunye nokunciphisa ukuvuvukala.Kubalulekile ukuba uqaphele ukuba ngelixa i-8-BMX iye yafundiswa ngokusetyenziswa kwayo kunye nemiphumo, izicelo zayo eziphathekayo ngaphandle kwezicwangciso zophando zilinganiselwe.Njenge-synthetic compound, ayifumaneki ngokuthengisa ukusetyenziswa ngokubanzi okanye ukusetyenziswa.Kwishishini lamachiza, ezinye i-xanthines ezifana ne-caffeine okanye i-theophylline zisetyenziswa ngokuqhelekileyo ngenxa yeeprofayili zabo ezikhuselekileyo ezikhuselekileyo kunye neziphumo ezaziwa kakhulu. kuphando lwezenzululwazi njengomchasi okhethiweyo we-adenosine receptors.Ifundwe ngeziphumo zayo ezinokubakho kwinkqubo ye-nervous central, umsebenzi we-cardiovascular function, kunye nokuvutha.Nangona kunjalo, usetyenziso lwayo olusebenzayo ngaphandle kweseto lophando lulinganiselwe, kwaye ezinye ii-xanthines ezinjenge-caffeine zisetyenziswa kakhulu kwaye zamkelwa.