Iimveliso

I-Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride yikhemikhali esetyenziswa ngokuqhelekileyo kuphando lwamachiza kunye nophuhliso lweziyobisi.Ulwakhiwo lwalo lwemolekyuli luquka iqela le-benzyl elidityaniswe kwiqela elisebenzayo le-carbamate ngokusebenzisa i-piperidine moiety.Enye yezinto eziphambili zokusetyenziswa kwe-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride injenge-precursor okanye phakathi ekudibaneni kweekhompawundi ezahlukeneyo zamachiza.Ubukho beringi ye-piperidine ibonelela le khompawundi ngokuguquguquka kwi-organic chemistry reactions, iyenza ibe yinto exabisekileyo yokuqala ukwakhiwa kweemolekyuli eziyinkimbinkimbi ezahlukeneyo.Ngokuzisa le khompawundi kwindlela yokwenziwa, iikhemisti zinokufikelela kuluhlu olubanzi lweekhompawundi zenoveli ezinezicelo zonyango ezinokubakho.Ngaphezu koko, iBenzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ingasetyenziswa njenge ibhloko yokwakha kuphuhliso lwamachiza amatsha ajolise kwiindlela ezithile zebhayoloji okanye ii-receptors.Iimpawu zayo zesakhiwo zenza ukuba zilungele ukufakwa kwiimolekyuli zamachiza, zisebenza njenge-pharmacophore okanye iqela eliphambili elisebenzayo elijongene nomsebenzi ofunekayo.Ngokuguqula i-benzyl, i-piperidine, okanye i-carbamate components, abaphandi banokwandisa amandla eziyobisi, ukukhetha, kunye neempawu ze-pharmacokinetic.Ikhompawundi inokuphinda isebenze njengesixhobo okanye i-reference compound yokufumanisa iziyobisi kunye nobudlelwane be-structure-activity (SAR) izifundo.Ngokuthelekisa umsebenzi webhayoloji wezinto ezahlukeneyo eziphuma kuzo okanye i-analogues ye-Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride, abaphandi banokufumana ulwazi malunga nobudlelwane bomsebenzi wesakhiwo, okubavumela ukuba bayile amandla kunye neekhompawundi ezikhethiweyo.Olu lwazi lubalulekile ekuphuculeni iikhompawundi zelothe kunye nophuhliso lwabagqatswa bamachiza abasebenzayo.Ukongezelela, iBenzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ingasetyenziswa kuphando lwemichiza yamayeza. ukufunda indlela yokusebenza yamachiza athile okanye ukuphanda imetabolism yeziyobisi.Ngokusebenzisa i-radiolabeleled okanye i-tagged version yale khompawundi, abaphandi banokulandela ukuhanjiswa kwayo kunye nemetabolism kwiinkqubo zebhayoloji.Olu lwazi lunceda ekuqondeni indlela amachiza acutshungulwa ngayo kwaye akhutshiwe emzimbeni, enika ulwazi oluxabisekileyo ekusebenzisaneni kweziyobisi, iirejimeni zedosi, kunye nokusebenzisana kweziyobisi ezinokwenzeka.Ngokufutshane, iBenzyl N-[2-(piperidin-4-yl) propan- I-2-yl]carbamate hydrochloride yikhompawundi eguquguqukayo esetyenziswa kakhulu kuphando lwamayeza kunye nophuhliso lwamachiza.Iimpawu zayo zesakhiwo zenza ukuba zixabiseke njenge-precursor ye-synthesis ye-pharmaceutical compounds ezahlukeneyo kunye nesakhiwo sokwakhiwa kwamachiza amatsha.Ngaphaya koko, isebenza njengesixhobo sezifundo ze-SAR, ukufunyanwa kweziyobisi, kunye nophando lwemetabolism.Izicelo ezahlukeneyo ze-Benzyl N-[2-(piperidin-4-yl) propan-2-yl]carbamate hydrochloride zigxininisa ukubaluleka kwayo ekuphuhliseni i-agent entsha yonyango kunye nokuqhubela phambili kwe-chemistry yamayeza.