Iimveliso

I-Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride yikhemikhali yekhemikhali efumana isicelo kwintsimi ye-chemistry yamayeza kunye nophuhliso lweziyobisi.Isakhiwo sayo se-molecular siqukethe i-pyrrolidine indandatho kunye neqela le-tert-butyl kwindawo ye-cis, iqela le-ethyl, kunye namaqela amabini e-carboxylate.Le khompawundi ifumaneka ngokuqhelekileyo ngendlela yetyuwa ye-hydrochloride.Enye yezona zinto zisetyenziswayo eziphambili ze-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ikwi-synthesis kunye nophuhliso lwamachiza olujoliswe kwindawo ephakathi. inkqubo ye-nervous (CNS).Ubukho bendandatho ye-pyrrolidine, kunye ne-tert-butyl kunye namaqela e-ethyl, inika le ngqungquthela kunye neempawu ezinokuthi zibe neuroactive.Abaphandi banokusebenzisa le khompawundi njengento yokuqala ukudibanisa i-analogs okanye i-derivatives enokukhetha ukusebenzisana kunye ne-receptors ethile okanye i-enzymes kwi-CNS.Ngokuguqula isakhiwo kunye neendawo ezithathayo, ziyakwazi ukulungelelanisa i-pharmacokinetic ye-compound, ikhulise i-receptor yayo, kunye nokuphucula amandla ayo onyango.Ngaphezu koko, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ingaba iqeshwe njengekhompawundi yesixhobo kwizifundo zebhayoloji ukuphanda indima yezamkeli ezithile okanye i-enzymes kwiinkqubo ze-neurological.Ngokusebenzisa le khompawundi njenge-ligand okanye i-probe, abaphandi banokufunda ubudlelwane obubophezelayo, ukukhetha, kunye nendlela yokusebenza kwezi receptor okanye i-enzymes.Olu lwazi lubalulekile ekuqondeni isiseko semolekyuli yeenkqubo ze-neuropharmacological kunye nophuhliso lwenoveli yonyango olujolise kwi-neurodeergenerative disorders, iimeko zengqondo, okanye izifo ze-neurological.Ikhompawundi inezicelo ezinokubakho ekufumaneni iziyobisi kunye novavanyo oluphezulu lwe-high-throughput screening.Inokuthi ifakwe kwiilayibrari zeekhompawundi, ezihlolwe ngokuchasene neenjongo ezahlukeneyo, ezifana ne-receptors okanye i-enzymes, ukuchonga iikhompawundi ezinokukhokelela okanye abaviwa beziyobisi.Olu vavanyo luvumela ukuchongwa kwee-compounds ezibonisa iimpawu ezinqwenelekayo ze-pharmacological okanye iziphumo ezinokubakho zonyango.Ngaphezu koko, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride inokufumana uncedo ekuphuhliseni i-prodrugs.Iimveliso zingasebenzi okanye zingasebenzi kakhulu iikhompawundi ezenzelwe ukuba zenziwe i-metabolized zibe yifom esebenzayo kanye ngaphakathi emzimbeni.Ngokuguqula ukwakheka kwale khompawundi, abaphandi banokwenza iifom zeprodrug ezizinzileyo, eziphucule ukufumaneka kwe-bioavailability, okanye ezinokuwela i-biological membranes ngokulula ngakumbi.Oku kunokunyusa izibonelelo zonyango ze-compound kunye nokuphucula iimpawu zayo ze-pharmacokinetic.Ngesishwankathelo, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride i-compound enezicelo ezinokuthi zisetyenziswe ekuphuhliseni iziyobisi ezijoliswe kwi-CNS. , njengekhompawundi yesixhobo sezifundo zebhayoloji, ekubhaqweni kweziyobisi, nakuphuhliso lweziyobisi.Ubume bayo obukhethekileyo bemolekyuli bubonelela ngamathuba ohlengahlengiso kunye nokwenza ngcono ukuphucula iipropathi zayo zekhemesti kunye nemisebenzi yebhayoloji.Ukuguquguquka kunye namandla ale khompawundi kwenza ukuba ibe yi-asethi ebalulekileyo kwintsimi ye-chemistry yamayeza kunye nophuhliso lweziyobisi.