Ityuwa ye-Creatine phosphate disodium Cas: 922-32-7 98% Umgubo otyheli
| Inombolo Yekhathalogu | XD90171 |
| Igama lemveliso | Creatine phosphate disodium ityuwa |
| CAS | 922-32-7 |
| Ifomula yeemolekyuli | C4H8N3Na2O5P · 4H2O |
| Ubunzima beMolekyuli | 327.14 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29299000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo otyheli |
| uAsay | >98.0% min |
| Amanzi | <0.5% |
| Iintsimbi ezinzima | <5ppm |
I-Cardioprotectant: I-Creatine phosphate yinto ebalulekileyo enikezela amandla ekunciphiseni kwemisipha kunye ne-metabolism.Yindawo yokugcina amandla ekhemikhali yezihlunu ezigudileyo kunye nezihlunu ezibethelelweyo, kwaye isetyenziselwa ukwenziwa kwakhona kwe-ATP.I-Phosphocreatinedisodium yindlela yayo yonyango.I-Sodium Creatine Phosphate, igama lekhemikhali N-[imino (phosphono) methyl]-N-methylglycine disodium ityuwa, i-agent ye-cardioprotective eqaliswe yi-Italian Ouhui Pharmaceutical Factory kwi-1992. Ifom ye-phosphocreatine idlala indima ebalulekileyo ye-physiological indima, kwaye isetyenziswa ngokubanzi ukukhuselwa kwe-myocardial kwizigulane ezine-ischemia yenhliziyo okanye ngexesha lotyando lwe-Chemicalbook yenhliziyo, kunye nokunyangwa kwezifo ze-cardiovascular ezifana nokuhluleka kwentliziyo, i-myocardial infarction kunye ne-arrhythmia.Inokuphucula umsebenzi wentliziyo kunye nokuhluka kwentliziyo kwizigulane ezine-ischemic cardiomyopathy.Ayinakukwazi ukubonelela kuphela amandla kwiiseli ze-myocardial xa zihlaselwa yi-ischemia kunye ne-hypoxia, kodwa zikhusela iiseli ze-myocardial membranes ekuhlaselweni kwe-oxygen free radicals kunye nezinye izinto ezinobungozi, ezinokuchaphazela umsebenzi wenhliziyo.Ukukhuselwa kwe-myocardial ye-postoperative kwizigulane ezine-valvular engafanelekanga kunenzuzo ekubuyiseleni emva kokusebenza kwentliziyo kwizigulane ezinesifo se-valvular.Ukuyisebenzisa ukunyanga ngokupheleleyo umonakalo we-myocardial emva kwe-asphyxia yosana kunokuphucula ngokubonakalayo ii-enzymes ze-myocardial kunye ne-electrocardiogram, kwaye inesiphumo esihle sokunyanga kunye nokhuseleko.
Iimpawu zomsebenzi Le mveliso iyindawo yokugcina amandla ekhemikhali yentliziyo kunye nemisipha yamathambo, kwaye isetyenziselwa ukuhlaziywa kwe-ATP, inika amandla kwinkqubo ye-actomyosin contraction, kwaye idlala indima ebalulekileyo kwi-metabolism yamandla e-muscle contraction.Ukungonelanga kwamandla yinto ebalulekileyo ekubunjweni nasekuphuhliseni ukulimala kweseli ye-myocardial.
1. Inempembelelo ebalulekileyo yokukhusela kwi-ischemic myocardial systolic function, enokubuyisela ngokupheleleyo ukuxhamla kunye nokunciphisa ngokukhawuleza uxinzelelo lwegazi lwe-diastolic.
2. Gcina umxholo we-adenosine triphosphate kunye ne-creatine phosphate kwiiseli, kwaye i-Chemicalbook igcina i-myocardial energy reserve.
3. Ukunciphisa ukulahleka kwe-creatine kinase kunye nokunciphisa umonakalo we-membrane yeseli.
4. Ineempawu ezichasene ne-peroxidation.
5. Ukuphucula i-myocardial microcirculation.Ngenxa yobukho be-high-energy phosphate bond in creatine phosphate molecules, i-high-energy phosphate bonds inokuguqula ngokuthe ngqo i-ADP ibe yi-ATP phantsi kwesenzo se-creatine phosphate, kwaye inike ngokuthe ngqo amandla kumzimba ukuba usebenze ngokukhawuleza.Njengemveliso ephakathi ye-glycolysis, i-sodium fructose diphosphate kufuneka idlale indima engathanga ngqo nge-anaerobic metabolism.
indlela yokwenziwa:
1 Ukusebenzisa dibenzyl phosphate njengento ekrwada, sabela nge oxalyl chloride ukufumana dibenzyl oxyphosphoryl chloride,
I-2 Ngaphantsi kwesenzo se-triethylamine, i-dibenzyloxyphosphoryl creatine ethyl ester efunyenwe ngokusabela nge-creatine ethyl ester hydrochloride ihamba ngebhayisikili kwi dibenzyloxyphosphoryl creatinine,
3. Emva kwepalladium carbon catalyzed hydrogenolysis to debenzylate, sabelane nesodium hydroxide ukufumana i-disodium creatinine phosphate,
I-4 i-hydrolyzed ukuya kwi-1 phantsi kwesenzo se-sodium hydroxide.
Ukusetyenziswa: Kufanelekile ukukhusela i-metabolism ye-myocardial engaqhelekanga kwimeko ye-ischemia ye-myocardial.
Ukuphendula okungathandekiyo, ukuchasana kunye nemiphumo yeziyobisi: abo baxhamla kumacandelo ale mveliso banqatshelwe;abo banokungaphumeleli kwezintso ezingapheliyo banqatshelwe ukusebenzisa iidosi ezinkulu (5-10g / d).Inaliti ekhawulezayo ye-intravenous engaphezulu kwe-1g inokubangela ukuhla koxinzelelo lwegazi.Ulawulo lwe-dose ephezulu lukhokelela kwi-phosphate intake ephezulu, enokuchaphazela i-calcium metabolism kunye ne-secretion ye-hormone elawula i-homeostasis, echaphazela umsebenzi wezintso kunye ne-purine metabolism.
