Iimveliso

I-N(ε)-trifluoroacetyl-L-lysine yi-derivative ethile ye-amino acid lysine, apho i-epsilon (ε) iqela le-amino likhuselwe liqela le-trifluoroacetyl (TFA).Le khompawundi ifumana isicelo kwiindawo ezahlukahlukeneyo, ngakumbi kwi-peptide synthesis kunye nophando lwe-biochemical.Olunye usetyenziso olukhulu lwe-N (ε) -trifluoroacetyl-L-lysine lukwisigaba esiqinileyo se-peptide synthesis (SPPS).Iipeptides zidlala indima ebalulekileyo kwiinkqubo ezininzi zebhayoloji, kwaye ukuhlanganiswa kwazo kufuna ukudibana ngokulandelelana kweeamino acid.Iqela elikhuselayo le-TFA kwiqela le-epsilon amino le-lysine lithintela ukuphendula okungafunekiyo ngexesha lokwenziwa kwebhondi ye-peptide ngelixa livumela ezinye ii-amino acids ukuba zitshatane kwindawo ezinqwenelekayo.Nje ukuba indibano yepeptide igqitywe, iqela elikhuselayo le-TFA lingasuswa ngokukhethayo, kwaye intsalela ye-N(ε)-trifluoroacetyl-L-lysine inokwandiswa ngakumbi ukwenza ulandelelwano oluthile lwepeptide.N(ε)-trifluoroacetyl-L-lysine nayo isetyenziswe kuphando lwe-biochemical ukufunda ubume beprotheyini, umsebenzi, kunye nokunxibelelana.Ingasebenza njengesixhobo sokuphanda indima yeentsalela ze-lysine kwi-protein-protein interactions, i-protein-DNA interactions, kunye nokuguqulwa kwe-post-translation.Ngokuzisa iqela le-TFA, iimpawu zeekhemikhali ze-lysine zinokuguqulwa, zivumela uphando lweenkqubo ezithile ze-lysine-mediated kwiinkqubo ze-biological. iinkqubo zokuhanjiswa kweziyobisi.Ngokudibanisa ii-agent ezithile zonyango kwi-residu ye-lysine ngokusebenzisa iqela le-TFA, kunokwenzeka ukwandisa ukuzinza kunye nokukhetha kweyeza, okukhokelela ekusebenzeni okuphuculweyo kunye nokunciphisa iziphumo ezibi.Esi sicwangciso sihlolwe ekuhanjisweni kwamachiza e-anticancer, i-antibiotics, kunye nezinye iindlela zonyango.Ngaphezu kwezicelo zayo ezithe ngqo, i-N (ε) -trifluoroacetyl-L-lysine nayo ingasetyenziselwa njengesakhiwo sokwakha ukuhlanganiswa kwamanye ama-compounds asebenzayo. .Ubume balo beekhemikhali ezizodwa kunye nokusebenza kwakhona kwenza kube yinto ekhangayo yokuqala okanye ephakathi kwi-synthesis ye-molecule eyinkimbinkimbi yezinto eziphilayo, kubandakanywa amayeza, i-agrochemicals, kunye nezinto eziphathekayo. kulandela amanyathelo okhuseleko afanelekileyo.Kuyacetyiswa ukuba kusetyenzwe kwilabhoratri engenisa umoya kwaye usebenzise izixhobo ezifanelekileyo zokuzikhusela, ezinjengeeglavu kunye nezibuko zokhuseleko. Isishwankathelo, i-N(ε)-trifluoroacetyl-L-lysine yinxalenye exabisekileyo ye-lysine efumana usetyenziso olwahlukeneyo kwi-peptide. i-synthesis, uphando lwe-biochemical, ukuhanjiswa kweziyobisi okujoliswe kuyo, kunye ne-organic synthesis.Ikhono layo lokukhusela iqela le-epsilon amino le-lysine livumela i-peptide synthesis echanekileyo, ngelixa iimpawu zayo zemichiza ezitshintshiweyo zenza ukuba kufundwe iinkqubo ze-lysine-mediated.Xa iphathwa kakuhle, i-N(ε)-trifluoroacetyl-L-lysine ingqina ukuba sisixhobo esiluncedo kwiinkqubo ezahlukeneyo zenzululwazi nezoshishino.