I-Cas eluhlaza ngokukhawuleza: 2353-45-9 Ebomvu ukuya kumgubo omdaka
| Inombolo Yekhathalogu | XD90527 |
| Igama lemveliso | Uluhlaza ngokukhawuleza |
| CAS | 2353-45-9 |
| Ifomula yeemolekyuli | I-C37H34N2Na2O10S3 |
| Ubunzima beMolekyuli | 808.85 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Imbonakalo | Ubomvu ukuya kumgubo omdaka |
| Isivavanyi | ≥99% |
| Izinto ezinganyibilikiyo ngamanzi | ≤0.20% |
Ukuvuvukala okungapheliyo kwendlela yomoya kunye nokulungiswa kwakhona, kubandakanywa ne-fibrosis, kucetywayo njengegalelo elibalulekileyo kwi-asthma pathophysiology.Uphononongo lwangaphambili lwe-airway fibrosis lwenziwe ikakhulu kwi-asthmatics ethambileyo kunye nephakathi kwinqanaba le-subepithelial "basement membrane" (SBM).Uphononongo lwangoku lwenzelwe ukuvavanya ubukhulu be-SBM ye-airway kunye ne-submucosal collagen deposition, njengoko kulinganiswe ngeendlela ezintathu ezahlukeneyo zokungcolisa i-collagen, kwi-endobronchial biopsies ukusuka kwi-17 enzima, ephakathi, kunye nesixhenxe se-asthmatics epholileyo, kunye nezifundo ezisibhozo zokulawula eziqhelekileyo.I-eosinophils yezicubu kunye nokuguqula ukukhula kwe-beta (i-TGF-beta) ukunganyangeki kwakhona kwavavanywa.Kwakungekho nantlukwano ephawulekayo kwi-SBM ubukhulu, i-submucosal collagen deposition, amanani e-eosinophil, okanye iiseli ze-TGF-beta ezintle phakathi kwamaqela amathathu e-asthmatics kunye nezifundo zokulawula eziqhelekileyo.Kuphela xa kuhlolwa zonke i-asthmatics (n = 33) kunye, ukuba i-SBM ethobileyo (p = 0.04), njengoko ivandlakanywe yi-collagen yohlobo lwe-III immunostaining, yabonwa xa kuthelekiswa nezifundo zokulawula eziqhelekileyo.Nangona lo mahluko, akukho ntlukwano ebalulekileyo efunyenwe kwinani le-submucosal collagen deposition kunye nenani le-eosinophils okanye i-TGF-beta ebonisa iiseli xa kuthelekiswa ne-asthmatics epheleleyo kunye nezifundo zokulawula eziqhelekileyo.Ukongezelela, akukho kulungelelaniswa okubalulekileyo kufunyenwe phakathi kwe-collagen deposition kunye ne-eosinophil count, i-TGF-beta inqanaba lokubonisa, i-FEV1, okanye ubude be-asthma.Ezi ziphumo zibonisa ukuba nangona ukunyuka kwe-collagen deposition kwi-SBM kwinqanaba elikhulu lomoya liyimpawu ye-asthma, ayinakuchaza ukungafani kobunzima be-asthma.
