Iimveliso

I-Flucytosine, eyaziwa ngokuba yi-5-fluorocytosine okanye i-5-FC, iyeza lokwenziwa kwe-antifungal esetyenziswa ngokuyintloko kunyango lwezifo zokungunda.Ihlelwa njenge-antimetabolite, oku kuthetha ukuba iphazamisa iinkqubo eziqhelekileyo ze-metabolic zeeseli zefungal, ezikhokelela ekuvinjweni kwazo okanye ekufeni.I-Flucytosine idla ngokulawulwa ngokudibeneyo kunye nezinye ii-antifungal agents ukuze zisebenze ngokufanelekileyo.Enye yezinto eziphambili zokusetyenziswa kwe-flucytosine kunyango lwe-invasive fungal infections, ingakumbi ezo zibangelwa yi-Candida kunye ne-Cryptococcus.Ihlala isetyenziswa ngokudityaniswa nenye i-antifungal agent, efana ne-amphotericin B okanye i-fluconazole, ukwandisa umsebenzi wayo wokulwa nokungunda.I-Flucytosine isebenza ngokungena kwiiseli zefungal kunye nokuguqulwa kwi-5-fluorouracil, i-cytotoxic antimetabolite.I-5-fluorouracil ke iphazamisa ukuhlanganiswa kwe-RNA yefungal kunye ne-DNA, ngaloo ndlela inqanda ukukhula kwefungal kunye nokuphindaphinda.Le ndlela ye-synergistic inceda ukulwa ne-spectrum ebanzi ye-fungal pathogens kunye nokwandisa unyango.I-Flucytosine ithathwa njengenye yonyango lodidi lokuqala ngokudityaniswa ne-amphotericin B kunyango lwesi sifo.Unyango oludityanisiweyo lunceda ukoyisa imida yechiza ngalinye lilodwa kunye nokufikelela kumazinga aphezulu okunyanga.I-Flucytosine ifikelela kumanqanaba afanelekileyo kwi-cerebrospinal fluid, ivumela ukuba ijolise ngokufanelekileyo kwintsholongwane ye-fungal kwi-system ye-nervous central.Nangona kunjalo, ukusetyenziswa kwayo kunokunciphisa ngenxa yomngcipheko wokuphuhlisa ukuchasana, njengoko i-fungus inokufumana iinguqu ezenza ukuba kungabi lula kwiyeza.Ukubeka iliso ngokusondeleyo kunye nokuhlolwa kwexesha lokuphendula lonyango kubalulekile xa usebenzisa i-flucytosine ukuqinisekisa iziphumo ezifanelekileyo zonyango.Nangona i-flucytosine ixhatshazwa kakuhle, ingaba nemiphumo emibi.Iziphumo eziqhelekileyo ezichaphazelekayo ziquka ukuphazamiseka kwesisu, njengesicaphucaphu, ukuhlanza, kunye nohudo.Kwakhona kunokubangela ukucinezelwa komongo, nto leyo enokubangela ukuncipha kokuveliswa kweeseli zegazi.Uvavanyo lwegazi oluqhelekileyo luhlala lwenziwa ukujonga ukubalwa kweeseli zegazi ngexesha lonyango.Ngokufutshane, i-flucytosine iyiyeza elichasayo elisetyenziselwa unyango oludibeneyo kunyango lwezifo zefungal, ngakumbi ezo zibangelwa yi-Candida kunye ne-Cryptococcus iintlobo.Isebenza ngokuphazamisa i-fungal nucleic acid synthesis, inqanda ukukhula kwabo kunye nokuphindaphinda.I-Flucytosine iqhele ukusetyenziswa kunye nezinye ii-antifungal agents kwaye ibaluleke kakhulu kunyango lwe-Cryptococcus neoformans meningitis.Nangona kunjalo, ukusetyenziswa kwayo kufuna ukubeka iliso ngenyameko ngenxa yomngcipheko wokuchasana kunye nemiphumo emibi enokubakho.