I-Heparin sodium Cas: 9041-08-1 emhlophe okanye phantse emhlophe, i-hygroscopic powder
| Inombolo Yekhathalogu | XD90184 |
| Igama lemveliso | Heparin sodium |
| CAS | 9041-08-1 |
| Ifomula yeemolekyuli | I-C12H17NO20S3 |
| Ubunzima beMolekyuli | 591.45 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 30019091 |
Ukucaciswa kweMveliso
| Imbonakalo | imhlophe okanye iphantse imhlophe, i-hygroscopic powder |
| uAsay | 99% |
| Ukujikeleza okuthe ngqo | Impahla eyomileyo akufanele ibe ngaphantsi kwe +50 ° |
| pH | 5.5 - 8.0 |
| I-endotoxin yebhaktheriya | Ngaphantsi kwe-0.01 IU kwiYunithi yaMazwe ngaMazwe ye-heparin |
| Isinyibilikisi esishiyekileyo | Ngokwendlela yomgangatho wangaphakathi enendawo encopho yokubala, i-methanol, i-ethanol, i-acetone, kwaye, ngokulandelelana, i-0.3%, 0.5%, okanye ngaphantsi. |
| Intsalela kwi-Ignition | 28.0%-41.0% |
| Isodium | 10.5% -13.5% (into eyomileyo) |
| Iprotheni | <0.5% (into eyomileyo) |
| Nitrogen | 1.3%-2.5% (into eyomileyo) |
| Ukungcola kweNucleotidic | 260nm<0.10 |
| Intsimbi enzima | ≤ 30ppm |
| Ukucaca kunye nombala wesisombululo | Isisombululo kufuneka sicace ngaphandle kombala;Njenge-turbidity, i-spectrophotometry ye-ultraviolet-ebonakalayo, ukuzimisela ukunyanzeliswa kwi-wavelength ye-640 nm, ayiyi kuba ngaphezu kwe-0.018;Okufana nombala, xa kuthelekiswa nolwelo oluqhelekileyo lwe-colorimetric elulwelo, aluyi kuba nzulu |
| Into enxulumeneyo | Isamba se-dermatan sulfate kunye ne-chondroitin sulphate: akukho ngaphezu kwe-aera ye-peak ehambelanayo kwi-chomatogram efunyenwe ngesisombululo sokubhekisela.Nakuphi na okunye ukungcola: akukho zincopho ngaphandle kwencopho ngenxa ye-determatan sulfate kunye ne-chondroitin sulfate zifunyenwe. |
| anti-FXa/anti-FIIa | 0.9-1.1 |
| Ichromatography yolwelo | Ukulawula isisombululo sesampulu kwichromatogram, idermatan sulfate (ubude obuphezulu kunye ne-heparin kunye ne-dermatan sulfate) phakathi kwe-peak valley height ratio ayiyi kuba ngaphantsi kwe-1.3, efunyenwe kunye nesisombululo sovavanyo iyafana ngexesha lokugcinwa kunye nokumila kwincopho eyintloko kwichromatogram efunyenwe isisombululo sereferensi.Ukutenxa kubudlelwane bexesha lokugcinwa akuyi kudlula kwi-5% |
| Ubunzima bemolekyuli kunye nokusabalalisa ubunzima bemolekyuli | Ubunzima bobunzima bemolekyuli kufuneka bube yi-15000 - 19000. Ubunzima bemolekyuli obungaphezulu kwe-24000 yebakala abuyi kuba bukhulu kune-20%, ubunzima bemolekyuli ye-8000 - 16000 ye-molecular weight 24000 - 16000 yomlinganiselo akufanele ibe ngaphantsi. kuno-1 |
| ilahleko ubunzima owomileyo | ≤ 5.0% |
| Izinto ezincinci | Ubalo lwe-aerobic olusebenzayo: <10³cfu/g.Umngundo/igwele <10²cfu/g |
| anti-factor IIa | ≥180 IU/mg |
I-Heparin, ityuwa yeSodium yi-polymer ye-heparin evelisa umphumo wayo omkhulu we-anticoagulant ngokuvula i-antithrombin.Oku kusebenze kubangela utshintsho oluhambelanayo kwi-ATIII kwaye ivumela ukwanda kokuguquguquka kwi-loop yayo yesayithi esebenzayo.I-Heparin yi-glycosaminoglycan ene-sulfate kakhulu eyaziwa ngokuthintela amahlwili.I-Heparin, iTyuwa yeSodium nayo i-activator ye-RyR kunye ne-ATIII.
Iimpawu zomzimba kunye neekhemikhali: I-sodium ye-Heparin imhlophe okanye iphantse ibe ngumgubo omhlophe, ayinavumba, i-hygroscopic, i-soluble emanzini, ayinyibiliki kwii-solvents eziphilayo ezifana ne-ethanol kunye ne-acetone.Inomrhumo onamandla ongalunganga kwisisombululo se-aqueous kwaye inokudibanisa kunye nezinye ii-cations ukwenza ii-molecular complexes.Izisombululo ezinamanzi zizinzile ngakumbi kwi-pH 7.
I-Anticoagulant: I-sodium ye-Heparin yi-anticoagulant, i-mucopolysaccharide, ityuwa yesodium ye-glucosamine sulfate ekhutshwe kwi-intestinal mucosa yeehagu, iinkomo kunye neegusha, kwaye ikhutshwe ngamaseli e-mast emzimbeni womntu.Kwaye ngokwemvelo ikhona egazini.I-sodium ye-Heparin inemisebenzi yokuthintela ukuhlanganiswa kweplatelet kunye nokutshatyalaliswa, inqanda ukuguqulwa kwe-fibrinogen kwi-fibrin monomer, inqanda ukubunjwa kwe-thromboplastin kunye nokuchasana ne-thromboplastin eyenziwe, ukuthintela ukuguqulwa kweprothrombin kwi-thrombin kunye ne-antithrombin.I-sodium ye-Heparin inokulibazisa okanye ithintele i-coagulation yegazi zombini kwi-vitro nakwi-vivo.Indlela yokusebenza kwayo inzima kakhulu kwaye ichaphazela amakhonkco amaninzi kwinkqubo yokudibanisa.Imisebenzi yayo yile: ①inqanda ukwakheka kunye nomsebenzi wethromboplastin, ngaloo ndlela inqanda iprothrombin ekubeni yithrombin;②kwiqondo eliphezulu, inefuthe lokuthintela i-thrombin kunye nezinye izinto zokudibanisa, ukuthintela i-fibrinogen ekubeni yi-fibrin Protein;③ inokuthintela ukudityaniswa kunye nokutshatyalaliswa kweeplatelet.Ukongezelela, i-anticoagulant effect ye-heparin sodium isanxulumene ne-sulfate ehlanjululwe kakubi kwi-molecule yayo.Izinto ze-alkaline ezichajiwe kakuhle ezifana neprotamine okanye i-toluidine eluhlaza okwesibhakabhaka inokunciphisa intlawulo yayo engalunganga, ngoko inokuthintela i-anticoagulation yayo.isiphumo.Ngenxa yokuba i-heparin inokusebenza kwaye ikhulule i-lipoprotein lipase kwi-vivo, i-hydrolyze triglyceride kunye ne-low-density lipoprotein ye-chylomicrons, ngoko ke inefuthe le-hypolipidemic.I-sodium ye-Heparin ingasetyenziselwa ukunyanga isifo esibuhlungu se-thromboembolic, i-disseminated intravascular coagulation (DIC).Kwiminyaka yakutshanje, i-heparin ifunyenwe inefuthe lokususa i-lipids yegazi.Isitofu se-Intravenous okanye i-intramuscular injection enzulu (okanye i-injection subcutaneous), i-5,000 ukuya kwiiyunithi ze-10,000 ngexesha ngalinye.I-Heparin sodium ayinayo ityhefu encinci kwaye ukuthambekela ukopha okuzenzekelayo ngowona mngcipheko ubalulekileyo we-heparin overdose.Ayisebenzi ngomlomo, kufuneka ilawulwe ngesitofu.Inaliti ye-Intramuscular okanye i-subcutaneous injection iyacaphuka ngakumbi, ngamanye amaxesha ukuphazamiseka kuyenzeka, kwaye ukugqithisa ngokweqile kunokubangela ukubanjwa kwentliziyo;ngamanye amaxesha ukulahleka kweenwele kunye norhudo.Ukongeza, isenokubangela ukwaphuka okuzenzekelayo.Ukusetyenziswa kwexesha elide kunokubangela i-thrombosis, enokuthi ibe ngumphumo we-anticoagulase-III yokunciphisa.I-sodium ye-Heparin inqatshelwe kwizigulane ezinokuthambekela ukopha, isibindi esinzima kunye nokungasebenzi kakuhle kwezintso, uxinzelelo lwegazi olunzima, i-hemophilia, i-intracranial hemorrhage, i-peptic ulcer, abafazi abakhulelweyo kunye ne-postpartum, i-visceral tumors, i-trauma kunye nokuhlinzwa.
Ukusetyenziswa: Uphando lwe-Biochemical, olusetyenziselwa ukuthintela ukuguqulwa kweprothrombin kwi-thrombin, kunye ne-antithrombotic effect.
Ukusetyenziswa: I-sodium ye-Heparin yi-mucopolysaccharide ye-biochemical drug ekhutshwe kwi-porcine intestinal mucosa kunye nomsebenzi onamandla we-anticoagulant.UMclcan ufumene i-femoral mucopolysaccharide heparin kwizicubu zesibindi eziphuma ezinjeni ngelixa wayefunda indlela yokujika kwegazi.UBrinkous et al.ibonise ukuba i-heparin inomsebenzi we-anticoagulant.Emva kokuba i-heparin isetyenziswe njenge-anticoagulant kwizicelo zeklinikhi okokuqala, ifumene ingqalelo kwihlabathi lonke.Nangona inembali engaphezulu kweminyaka engama-60 ekusetyenzisweni kweklinikhi, akukho mveliso enokuthi iyithathele indawo ngokupheleleyo ukuza kuthi ga ngoku, ngoko iseyeyona nto ibalulekileyo ye-anticoagulant kunye ne-antithrombotic biochemical drug.Inoluhlu olubanzi lokusetyenziswa kweyeza.Isetyenziselwa ukunyanga i-acute myocardial infarction kunye ne-pathogenic hepatitis.Ingasetyenziselwa ngokudibanisa ne-ribonucleic acid ukwandisa ukusebenza kwe-hepatitis B. Ingasetyenziselwa kunye ne-chemotherapy ukukhusela i-thrombosis.Inokunciphisa i-lipids yegazi kunye nokuphucula ukusebenza komzimba womntu.nayo inesiphumo esithile.I-molecular weight low heparin sodium ine-anticoagulant factor Xa umsebenzi.Uphononongo lwe-Pharmacodynamic lubonise ukuba ubunzima obuphantsi bemolekyuli ye-heparin yesodium ine-inhibitory effect ekubunjweni kwe-thrombus kunye ne-arteriovenous thrombosis kwi-vivo kunye ne-vitro, kodwa inefuthe elincinci kwi-coagulation kunye nenkqubo ye-fibrinolysis, ekhokelela kwimpembelelo ye-antithrombotic.ukopha akunakwenzeka.I-heparin engaqhekeki ngumxube wee-amino glucan glycosides ezahlukeneyo ezinokulibazisa okanye ukuthintela ukudityaniswa kwegazi kwi-vitro nakwi-vivo.I-anticoagulation mechanism yayo inzima, kwaye inefuthe kuyo yonke imiba ye-coagulation.Kubandakanya ukuvinjelwa kweprothrombin kwi-thrombin;ukuvinjelwa komsebenzi we-thrombin;ukuthintela ukuguqulwa kwefibrinogen kwifibrin;ukuthintela ukudityaniswa kweplatelet kunye nokutshatyalaliswa.I-Heparin isenako ukwehlisa i-lipids yegazi, i-LDL ephantsi kunye ne-VLDL, inyuse i-HDL, iguqule i-viscosity yegazi, ikhusele iiseli ze-vascular endothelial, ikhusele i-atherosclerosis, ikhuthaze ukuhamba kwegazi, kunye nokuphucula ukujikeleza kwe-coronary.
Ukusetyenziswa: Uphando lwe-Biochemical, ukukhusela ukuguqulwa kweprothrombin kwi-thrombin.
Ukusetyenziswa: Isetyenziselwa ukulibazisa kunye nokuthintela ukujiya kwegazi
