Hoechst 33258 Cas: 23491-45-4 Umgubo wekristale omthubi oPale
Inombolo Yekhathalogu | XD90536 |
Igama lemveliso | Hoehst 33258 |
CAS | 23491-45-4 |
Ifomula yeemolekyuli | C25H24N6O·3(HCl) |
Ubunzima beMolekyuli | 533.88 |
Iinkcukacha zokuGcina | -15 ukuya -20 °C |
IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
Imbonakalo | Umgubo wekristale omthubi |
Isivavanyi | 99% |
Ukusebenzisana phakathi kweyeza le-antidiabetic, i-Metformin kunye nethole i-thymus DNA (CT-DNA) kwi-buffer (50mM Tris-HCl) yaphononongwa yi-UV-Visible absorption, i-fluorescence, i-CD spectroscopy kunye nemilinganiselo ye-viscosity.Kwizifundo ze-fluorimetric, i-enthalpy kunye ne-entropy ye-reaction phakathi kwechiza kunye ne-CT-DNA ibonise ukuba impendulo i-exothermic (ΔH = -35.4522 kJ mol (-1); ΔS = -49.9523 J mol (-1) K (-1) )).Uphononongo olubophelelayo olukhuphisanayo lubonise ukuba ichiza linokukhulula iHoechst 33258 ngokupheleleyo.I-complex ibonise i-absorption hyperchromism kwi-UV-Vis spectrum yayo kunye ne-DNA.I-binding edibeneyo eqhubekayo, i-K (b), efunyenwe kwizifundo zokufunxa i-UV-Vis yayingu-8.3 × 10 (4) M (-1).Ngaphezu koko, utshintsho kwi-CD spectra phambi kobukho bechiza lubonisa ukuzinza kwe-right hand-hand-form ye-CT-DNA.Okokugqibela, imilinganiselo ye-viscosity ibonise ukuba ukudityaniswa kwe-complex kunye ne-CT-DNA kunokubophelela phezulu, ngenxa ye-groove binding.Copyright © 2012 Elsevier BV Onke amalungelo agciniwe.