I-L-Glutamic acid CAS: 56-86-0 99% iPowder emhlophe
| Inombolo Yekhathalogu | XD90312 |
| Igama lemveliso | D-Glutamic acid |
| CAS | 56-86-0 |
| Ifomula yeemolekyuli | C5H9NO4 |
| Ubunzima beMolekyuli | 147.13 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29224200 |
Ukucaciswa kweMveliso
| Imbonakalo | Ikristale emhlophe okanye i-Crystalline Powder |
| Isivavanyi | 99% |
| Ukujikeleza okuthe ngqo | +31,5 ukuya +32,5 ° |
| pH | 3.0 ukuya ku-3.5 |
| Ilahleko ekomisweni | 0.2% ubukhulu |
| Intsimbi | 10 ppm ubuninzi |
| AS2O3 | 1 ppm ubuninzi |
| Intsimbi enzima(Pb) | 10 ppm ubuninzi |
| Ammonium | 0.02% ubukhulu |
| Ezinye ii-amino acids | <0.4% |
| I-Chloride | 0.02% ubukhulu. |
| Intsalela ekutshisweni (iSulfated) | 0.1% ubukhulu |
| I-Sulfate (njenge-SO4) | 0.02% ubukhulu |
yena EAAT2 glutamate transporter, akhawunti ye>90% yehippocampal glutamate uptake.Nangona i-EAAT2 ibonakaliswa ikakhulu kwii-astrocytes, ~i-10% yeemolekyuli ze-EAAT2 zifumaneka kwiitheminali ze-axon.Ngaphandle kwenqanaba elisezantsi le-EAAT2 yokubonisa kwii-terminals ze-glutamatergic, xa izilayi ze-hippocampal zifukanywe ngoxinaniso oluphantsi lwe-d-aspartate (i-EAAT2 substrate), iitheminali ze-axon ziqokelela i-d-aspartate ngokukhawuleza njenge-astroglia.Oku kuthetha ukungangqinelani okungachazwanga phakathi kokusasazwa kweprotheyini ye-EAAT2 kunye nomsebenzi wothutho olawulwa yi-EAAT2.Enye ingqikelelo yeyokuba (1) utshintshiselwano nge-heteroexchange ye-substrate yangaphakathi kunye ne-substrate yangaphandle ikhawuleza kakhulu kunokuthathwa komnatha kwaye (2) ii-terminals zithanda ukutshintshiselana nge-heteroexchange ngenxa yamanqanaba aphezulu e-glutamate yangaphakathi.Nangona kunjalo, okwangoku akwaziwa ukuba i-heteroexchange kunye nokuthatha kunemilinganiselo efanayo okanye eyahlukileyo.Ukujongana nalo mbandela, sisebenzise inkqubo ehlaziyiweyo ukuthelekisa amaxabiso ahambelanayo kwiinkqubo ezimbini kwiigundane kunye neempuku.I-Net uptake yaba nemvakalelo yokutshintsha kwi-membrane enokubakho kwaye yakhuthazwa yi-anion yangaphandle ekwazi ukungena ngemvume kunye nobukho be-anion conductance engadityaniswanga.Ngokusebenzisa le yokugqibela, sikwabonisa ukuba izinga le-heteroexchange likwaxhomekeke kwi-membrane enokubakho.Ukongezelela, idatha yethu iphakamisa ubukho bokuvuza kwe-sodium kwi-EAAT2.Ngokubandakanya izinto ezintsha ezifunyenweyo kwimodeli yethu yangaphambili yokuthatha i-glutamate yi-EAAT2, siqikelela ukuba uvakalelo lombane lokutshintshiselana lubangelwa kukubophelela kwe-voltage yesithathu exhomekeke kwi-Na(+).Ngaphaya koko, yomibini imifuniselo yethu kunye nokulinganisa kucebisa ukuba amaxabiso anxulumeneyo okufumana kunye ne-heteroexchange ayathelekiseka kwi-EAAT2.
