I-L-Glutamine Cas: 56-85-9 99% Umgubo omhlophe
| Inombolo Yekhathalogu | XD90309 |
| Igama lemveliso | L-Glutamine |
| CAS | 56-85-9 |
| Ifomula yeemolekyuli | I-C5H10N2O3 |
| Ubunzima beMolekyuli | 146.1445 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29241900 |
Ukucaciswa kweMveliso
| Ubushushu boGcino | +20 Deg C |
| Ubunzima beMolekyuli | 146.14 |
| Isivavanyi | 99.0% min |
| Imbonakalo | Umgubo omhlophe |
I-1.Early T-cell precursor leukemia (ETP-ALL) i-subtype ephezulu ye-leukemia yomntu engaqondakali kakuhle kwinqanaba le-molecular.Apha sichaza ukutshintshwa okujolise kumnwe we-zinc E-box-binding transcription factor ZEB2 njengesilonda sofuzo esiphindaphindiweyo kwi-immature/ETP-ALL.Sisebenzisa imodeli yemouse enemiqathango yokufumana umsebenzi, sibonisa ukuba iZeb2 ezinzileyo iqalisa i-T-cell leukemia.Ngaphaya koko, i-leukemia yempuku eqhutywa yiZeb2 ibonisa ezinye iimpawu zomsayino we-ETP-All gene expression, kunye nokwandisa amandla okuqalisa i-leukemia kunye ne-Janus kinase (JAK)/i-signal transducers kunye ne-activators of transcription (STAT) eyongeziweyo. ukusebenza kokubhaliweyo kwe-IL7R.Olu phononongo lutyhila i-ZEB2 njenge-oncogene kwibhayoloji yokungavuthwanga/ETP-YONKE kwaye ivula indlela eya kwizifundo zangaphambili zeklinikhi zekhompawundi zenoveli kunyango loluhlobo olunobundlongondlongo lwe-T-ALL yabantu kusetyenziswa imodeli yethu yempuku eqhutywa nguZeb2.
I-2.Pluripotency, ukuzihlaziya, kunye nokuhlukana zizinto ezikhethekileyo zeeseli ze-embryonic stem (ES), ngaloo ndlela zibonelela ngeembono ezixabisekileyo kwiyeza lokuvuselela.Iinkqubo zophuhliso zifuna umbutho olungelelanisiweyo, ngokukodwa ulawulwa yi-JAK / STAT eyaziwayo, i-PI3K / AKT, kunye ne-ERK / MAPK iindlela.I-SPREDs (iiprotheni ezinxulumene ne-Sprouty kunye ne-EVH1 domain) zifunyenwe njenge-inhibitors ye-ERK / MAPK indlela yokubonisa indlela, ngelixa akukho nto eyaziwayo malunga nemisebenzi yabo kwiiseli ze-ES kunye ngexesha lokuhlukana kwangaphambili, ngoku. iiseli zokuhlalutya imisebenzi yeeprotheni ze-SPRED kwiiseli ze-ES kunye nexesha lokwahlula kwangaphambili.Ukugqithiswa kwe-SPREDs kwandisa kakhulu ukuzihlaziya kunye ne-clonogenicity yeeseli ze-ES ze-murine, kanti ukungabikho kwe-SPRED2 kunciphisa ukwanda kunye nokwandisa i-apoptosis.Ngexesha lokwahlula kwangaphambili kwimizimba ye-embryoid, i-SPREDs ikhuthaza imeko ye-pluripotent kwaye inqanda ulwahlulo apho i-mesodermal d ifferentiation kwi-cardiomyocytes ilibazisekile kwaye ithintelwe.I-LIF- kunye ne-factor factor-stimulation ibonise ukuba i-SPREDs inqanda ukusebenza kwe-ERK / MAPK kwiiseli ze-ES ze-murine.Nangona kunjalo, akukho miphumo ifunyenwe kwi-LIF-induced activation ye-JAK / STAT3, okanye i-PI3K / AKT indlela yokubonisa indlela nge-SPRED proteins.Sibonisa ukuba i-SPREDs ikhuthaza ukuhlaziya kwaye inqanda ukuhlukana kwe-mesodermal yeeseli ze-murine ze-ES ngokucinezelwa okukhethiweyo kwe-ERK / Indlela yokubonisa i-MAPK kwiiseli ze-pluripotent.
