Iimveliso

I-Ornithine aspartate yayiyeyokuqala ukusetyenziswa kweklinikhi kunyango lwe-hangover kunye ne-hepatic encephalopathy.Ngokuqokelelwa kwamava esicelo seklinikhi, i-ornithine aspartate isetyenziswe ngokubanzi kunyango lwezifo zesibindi, kwaye iphumelele iziphumo ezichanekileyo zokunyanga kwi-hepatic encephalopathy, ukonakala kwesibindi okubangelwa ngamachiza, isibindi esinamafutha, i-hepatitis engapheliyo kunye nezinye izifo. iqatshelwe ngoogqirha.

I-Ornithine aspartate ibonelela nge-substrate ye-urea kunye ne-glutamine synthesis kwi-vivo.I-Glutamine yimveliso ye-detoxification ye-ammonia, kunye nokugcinwa kunye nokuthutha ifom ye-ammonia.Ngaphantsi kweemeko ze-physiological and pathological, i-synthesis ye-urea kunye ne-synthesis ye-glutamine ichaphazeleka yi-ornithine, i-aspartic acid kunye nezinye iikhompawundi ze-dicarboxyl.I-Ornithine ibandakanyeka phantse yonke inkqubo yokusebenza komjikelezo we-urea kunye ne-detoxification ye-ammonia.I-Arginine yenziwa ngexesha le nkqubo, kwaye i-urea iyahlukana ukuze yenze i-ornithine.I-Aspartic acid ithatha inxaxheba kwi-synthesis ye-nucleic acid kwi-hepatocytes ukuququzelela ukulungiswa kwe-hepatocytes eyonakele.Ukongeza, ngenxa yenkuthazo engathanga ngqo ye-aspartic acid kwinkqubo ye-metabolic yomjikelezo we-tricarboxylic acid kwiiseli zesibindi, ikhuthaza ukuhlanganiswa kwamandla kwiiseli zesibindi, ezinceda ekulungiseni iiseli ezonakeleyo zesibindi kunye nokukhawulezisa ukubuyiswa komsebenzi wesibindi.Inkqubela phambili yakutshanje ibonise ukuba i-aspartate inokuthintela umsebenzi we-inflammasomes ngokusebenzisa i-N-methyl-D-aspartate (NMDA) receptors, ngaloo ndlela inciphisa indlela ye-pharmacological yempendulo yokuvuvukala kwesibindi.I-NMDA i-receptors yi-subtype ye-ionotropic excitatory glutamate receptors, edlala indima ebalulekileyo kwiinkqubo ze-physiological ezifana ne-synaptic transmission, i-synaptic plasticity, ukufunda kunye nememori kwinkqubo ye-nervous central.Izifundo ezilandelayo ze-pathological ziqinisekisile ukuba i-aspartate iphucule kakhulu izilonda ezivuthayo kwisibindi.

Isicelo seklinikhi

Kwinkalo yesifo sesibindi: I-Ornithine aspartate isetyenziswa ngokubanzi njengeyeza elichasayo kunye ne-hepatoprotective kunyango lwezifo ezahlukeneyo zesibindi, ezifana ne-hepatic encephalopathy, umonakalo wesibindi owenziwe ngamachiza, isibindi esinamafutha, i-hepatitis engapheliyo, njl. igazi ammonia kwizigulana encephalopathy kunye isiqabu iimpawu neuropsychiatric ngokuthe ngcembe baba iyeza eliphambili lonyango kunyango lwezifo ezahlukeneyo zesibindi.

I-Ornithine aspartate yinxalenye ebalulekileyo yokwenziwa kwe-urea kunye ne-glutamine.I-Ornithine inokuvula i-enzymes eziphambili kwinkqubo ye-urea synthesis - i-ornithine carbamoyltransferase kunye ne-carbamoyl phosphate synthase, kwaye ikhuthaze i-ammonia Metabolism ukuphumeza ukuchithwa kwe-ammonia yegazi, i-aspartic acid njenge-substrate inokuvelisa i-glutamic acid kunye ne-oxaloacetic acid, i-detoxification yemveliso ye-glutamine ammonia, kwaye ikwayindawo yokugcina kunye nokuthuthwa kweammonia.I-Oxaloacetate ithatha inxaxheba kumjikelezo we-tricarboxylic acid, ikhuthaza ukuveliswa kwamandla kwiiseli zesibindi, kwaye yenza ukuba iiseli zesibindi ezonakalisiweyo zilungiswe, zihlaziywe, kwaye zibuyiselwe ukusebenza kwesibindi.I-Ornithine aspartate inokuphucula ngokufanelekileyo ukusebenza kwesibindi, ukunciphisa i-ammonia yegazi, kunye nokunciphisa i-ammonia nge-lactulose kunye ne-ofloxacin, ngaloo ndlela iphucula kakhulu izinga lokunyanga i-hepatic encephalopathy, efanele ukusetyenziswa kwekliniki.

I-Oncology: Ngotshintsho oluqhubekayo kwiindidi kunye needosi zamachiza e-chemotherapy, iingxaki ezinxulumene namachiza e-chemotherapy nazo ziyavela, kwaye umonakalo wesibindi ngomnye weyona monakalo uqhelekileyo welungu.Nje ukuba umonakalo wesibindi wenzeke, uya kuchaphazela impilo yomzimba kunye nengqondo yezigulana ukuya kumanqanaba ahlukeneyo, ukuthintela ukuphunyezwa kweerejimeni zechemotherapy, kwaye buthathaka isiphumo sonyango lwechemotherapy.Kwiimeko ezinzima, ukungasebenzi kwesibindi kunokubeka ubomi esichengeni.I-Ornithine aspartate inokuphucula kakhulu umonakalo wesibindi obangelwa ngamachiza e-chemotherapy kunye nokuphucula umphumo wonyango wezigulane ze-tumor.

Intsimi yotyando: Utyando kukubetheka kuwo wonke amalungu omzimba wesigulane, kwaye umonakalo wokusebenza kwesibindi emva kokuhlinzwa kukwayinto eqhelekileyo.I-Ornithine aspartate inokuthintela kwaye iphathe umonakalo wesibindi emva kokusebenza kunye nokukhuthaza ukubuyiswa kwezigulane emva kokuhlinzwa.