Iimveliso

Iziphumo ze-Pharmacological ze-theanine

1. Iimpembelelo kwinkqubo ye-nervous central

Xa ulinganisa umphumo we-theanine kwi-metabolism ye-monoamines kwiindawo ezahlukeneyo zobuchopho, uHeng Yue et al.ufumanise ukuba i-theanine inokukhuthaza kakhulu ukukhutshwa kwe-dopamine kumbindi wobuchopho kunye nokuphucula umsebenzi we-physiological we-dopamine engqondweni.I-Dopamine yi-neurotransmitter esembindini eyenza iiseli zemithambo-luvo yobuchopho zisebenze, kwaye umsebenzi wayo we-physiological unxulumene ngokusondeleyo nemeko yeemvakalelo zomntu.Nangona indlela yokusebenza ye-theanine kwinkqubo ye-nervous central yengqondo ayicacanga kakhulu.Kodwa impembelelo ye-theanine kumoya kunye neemvakalelo ngokungathandabuzekiyo ngokuyinxenye isuka kwisiphumo somsebenzi womzimba we-neurotransmitter ephakathi i-dopamine.Ewe kunjalo, isiphumo esichasene nokudinwa kokusela iti kukwakholelwa ukuba ivela kule mpembelelo ukuya kwinqanaba elithile.

Kwezinye iimvavanyo zabo, uYokogoshi et al.iqinisekisile ukuba ukuthatha i-theanine kuya kuchaphazela ngokuthe ngqo umsebenzi we-serotonin ye-neurotransmitter ebuchosheni enxulumene nokufunda kunye nenkumbulo.

2. Impembelelo ye-Antihypertensive

Ngokuqhelekileyo kukholelwa ukuba ukulawulwa koxinzelelo lwegazi lomntu kuchatshazelwa yimfihlo ye-neurotransmitters ephakathi kunye ne-peripheral catecholamine kunye ne-serotonin.Uphononongo lubonise ukuba i-theanine inokunciphisa ngokufanelekileyo uxinzelelo lwegazi oluzenzekelayo kwiimpuku.Kimura et al.wayekholelwa ukuba impembelelo ye-antihypertensive ye-theanine inokuvela kulawulo lokukhuselwa kwe-serotonin ye-neurotransmitter ephakathi kwingqondo.

Isiphumo se-hypotensive esiboniswa yi-theanine sinokubonwa njengesiphumo sokuzinzisa kwinqanaba elithile.Kwaye le mpembelelo yokuzinzisa ngokuqinisekileyo iya kunceda ukubuyiswa kokukhathala ngokomzimba nangokwengqondo.

3. Ichaphazela inkumbulo

Chu et al.baxela ukuba bafumene kwi-Operanttest (uvavanyo lokufunda lwezilwanyana apho ukutya kubonelelwa kunye nokutshintsha ukukhanya) isifundo kwaye bafumanisa ukuba iigundane ezinikwe i-180 mg ye-theanine ngomlomo yonke imihla yayinamandla okufunda angcono xa kuthelekiswa neqela lokulawula.uphuculo oluthile.Ukongeza, kuphononongo lovavanyo lokuphepha (uvavanyo lwenkumbulo yezilwanyana apho izilwanyana ziya kufumana ukothuka kombane kwigumbi elimnyama xa zingena kwigumbi elimnyama kunye nokutya okuvela kwigumbi eliqaqambileyo), kukwaqinisekiswa ukuba i-theanine inokuphucula amandla enkumbulo. yeempuku.Izifundo ezininzi zibonakalise ukuba isiphumo se-theanine ekuphuculeni ukufunda kunye nenkumbulo sisiphumo sokuvula ii-neurotransmitters ezisembindini.

4. Khululeka ingqondo nomzimba wakho

Kwangoko ngo-1975, uKimura et al.ingxelo yokuba i-theanine inokunciphisa i-hyperexcitability esembindini ebangelwa yi-caffeine.Nangona umxholo we-caffeine kumagqabi eti ungaphantsi kwalowo wekofu kunye nekoko, ubukho be-theanine benza abantu babe nemvakalelo ehlaziyayo xa besela iti leyo ikofu kunye nekoko.

Njengoko sonke sisazi, iintlobo ezine zamaza obuchopho, α, β, σ kunye no-θ, ezinxulumene ngokusondeleyo nesimo somzimba nengqondo yabantu, zinokulinganiswa kumphezulu wobuchopho bethu.Xa uChu et al.baqaphela umphumo we-theanine kumaza obuchopho be-15 abasetyhini abancinci abaneminyaka eyi-18 ukuya kwi-22, bafumanisa ukuba i-α-wave inokwanda okubonakalayo emva kokulawulwa komlomo kwe-theanine imizuzu engama-40.Kodwa phantsi kweemeko ezifanayo zovavanyo, abazange bafumane isiphumo se-theanine kwi-theta-wave yokulawula ubuthongo.Kwezi ziphumo, bakholelwa ukuba isiphumo esihlaziyayo somzimba nengqondo esibangelwa kukuthatha i-theanine asikokwenza abantu bathambekele ekulaleni, kodwa kukuphucula ukugxila.

5. Ukutya okunempilo

Uninzi lweemveliso zokutya okunempilo kwimarike zezokuthintela okanye ukuphuculwa kwezifo zabantu abadala.Ukutya okunempilo okufana ne-theanine engalalisi, kodwa kwakhona kukhulula ukudinwa, kwehlisa uxinzelelo lwegazi kwaye kuphucule ukufunda kunye nokukwazi ukukhumbula kunqabile kwaye kutsala amehlo.Ngesi sizathu, i-theanine iphumelele ibhaso lesebe lophando kwiNkomfa yeMpahla yoKutya yaMazwe ngaMazwe eyayibanjelwe eJamani ngo-1998.

I-Theanine yi-amino acid enomxholo ophezulu kwiti, ibala ngaphezu kwe-50% ye-amino acids yasimahla kunye ne-1% -2% yobunzima obomileyo bamagqabi eti.I-Theanine ngumzimba omhlophe onjengenaliti, inyibilika ngokulula emanzini.Inencasa eswiti nehlaziyayo kwaye iyinxalenye yencasa yeti.AmaJapan ahlala esebenzisa i-shading ukunyusa umxholo we-theanine kumagqabi eti ukunyusa ukutsha kwamagqabi eti.

(1) Ukufunxa kunye nemetabolism.

Emva kokulawulwa ngomlomo kwe-theanine emzimbeni womntu, ifunxwa ngomda webrashi yamathumbu, ingene egazini, kwaye isasazwe kwizicubu kunye namalungu ngokujikeleza kwegazi, kwaye inxalenye ikhutshelwa kumchamo emva kokubola. izintso.Ukuxinwa kwe-theanine efakwe egazini kunye nesibindi kwehle emva kweyure enye, kwaye i-theanine ebuchosheni ifikelele phezulu emva kweeyure ezi-5.Emva kweeyure ezingama-24, i-theanine emzimbeni womntu yanyamalala kwaye yakhutshwa ngendlela yomchamo.

(2) Ukulawula utshintsho lwee-neurotransmitters kwingqondo.

I-Theanine ichaphazela i-metabolism kunye nokukhululwa kwee-neurotransmitters ezifana ne-dopamine engqondweni, kwaye izifo zengqondo ezilawulwa zezi neurotransmitters zinokulawulwa okanye zithintelwe.

(3) Ukuphucula ubuchule bokufunda kunye nokukhumbula.

Kuvavanyo lwezilwanyana, kwafunyaniswa ukuba amandla okufunda kunye nenkumbulo yeempuku ezithatha i-theanine zazingcono kunezo zeqela lolawulo.Kwiimvavanyo zezilwanyana, kwafunyaniswa ukuba ukukwazi ukufunda kwavavanywa emva kokuthatha i-theanine kwiinyanga ezi-3-4.Iziphumo zovavanyo zibonise ukuba i-dopamine yoxinaniso lweempuku ezithatha i-theanine yayiphezulu.Zininzi iintlobo zovavanyo lwesakhono sokufunda.Enye kukubeka iimpuku ebhokisini.Kukho ukukhanya kwibhokisi.Xa ukukhanya kulayitiwe, cofa iswitshi kwaye ukutya kuya kuphuma.Iimpuku ezithatha i-theanine ziyakwazi ukuzazi izinto ezibalulekileyo ngexesha elifutshane, kwaye isakhono sokufunda siphezulu kuneso seempuku ezingathathi i-theanine.Okwesibini kukusebenzisa ithuba lomkhwa wempuku wokuzimela ebumnyameni.Xa impuku ibaleka ebumnyameni, yothuswa kukothuka kombane.Iimpuku ezithatha i-theanine zikholisa ukuhlala kwindawo eqaqambileyo ukunqanda ukothuka kombane, nto leyo ebonisa ukuba iyingozi ngakumbi kwindawo emnyama.inkumbulo eyomeleleyo.Ingabonwa ukuba i-theanine inefuthe lokuphucula imemori kunye nokukwazi ukufunda kweempuku.

(4) isiphumo sedative.

I-caffeine sisivuseleli esaziwayo, kodwa abantu baziva bekhululekile, bezolile, kwaye benomoya omnandi xa besela iti.Kuye kwaqinisekiswa ukuba oku ubukhulu becala yimpembelelo ye-theanine.Ukuthathwa ngaxeshanye kwe-caffeine kunye ne-amino acids kunempembelelo enkulu yokuthintela kwimincili.

(5) Ukuphucula i-syndrome yokuya esikhathini.

Uninzi lwabasetyhini bane-syndrome yokuya exesheni.I-Menstrual syndrome yimpawu yokukhathazeka kwengqondo kunye nomzimba kubasetyhini abaneminyaka eyi-25-45 kwiintsuku ze-3-10 ngaphambi kokuya esikhathini.Ngokwengqondo, ibonakaliswa ikakhulu njengokucaphuka lula, ukucaphuka, ukudakumba, ukungazinzi, ukungakwazi ukugxila, njl. njl iinyawo, njl njl. Umphumo wokuthomalalisa we-theanine ukhumbuza umphumo wayo wokuphucula kwi-syndrome yokuya esikhathini, ebonakaliswe kwiimvavanyo zeklinikhi kubasetyhini.

(6) Khusela iiseli zemithambo-luvo.

I-Theanine inokuthintela ukufa kweeseli zemithambo-luvo okubangelwa yi-cerebral ischemia edlulayo, kwaye inefuthe lokukhusela kwiiseli zemithambo-luvo.Ukufa kweeseli zemithambo-luvo kunxulumene ngokusondeleyo ne-excitatory neurotransmitter glutamate.Ukufa kweeseli kwenzeka xa kukho i-glutamate eninzi, edla ngokuba ngunobangela weemeko ezifana ne-Alzheimer's.I-Theanine ngokwesakhiwo iyafana ne-glutamic acid kwaye iya kukhuphisana kwiziza ezibophelelayo, ngaloo ndlela inqanda ukufa kweeseli zemithambo-luvo.I-Theanine ingasetyenziselwa unyango kunye nokuthintela ukuphazamiseka kwengqondo okubangelwa yi-glutamate, efana ne-cerebral embolism, i-cerebral hemorrhage kunye nezinye i-cerebral apoplexy, kunye nezifo ezifana nokunqongophala kwegazi kunye ne-senile dementia eyenzekayo ngexesha lotyando lobuchopho okanye ukulimala kwengqondo.

(7) Isiphumo sokunciphisa uxinzelelo lwegazi.

Kwiimvavanyo zezilwanyana, ukujova i-theanine kwiigundane ze-hypertensive ezizenzekelayo, uxinzelelo lwegazi lwe-diastolic, uxinzelelo lwegazi lwe-systolic kunye noxinzelelo lwegazi oluqhelekileyo lwancipha, kwaye iqondo lokunciphisa lalinxulumene nomthamo, kodwa akukho tshintsho olukhulu kwizinga lentliziyo;I-theanine yayisebenza kwiigundane eziqhelekileyo zoxinzelelo lwegazi.Kwakungekho mpembelelo yokunciphisa uxinzelelo lwegazi, ebonisa ukuba i-theanine yayinoxinzelelo lwegazi oluthotywayo kwiigundane ze-hypertensive.I-Theanine inokwehlisa uxinzelelo lwegazi ngokulawula ukuxinana kwee-neurotransmitters kwingqondo.

(8) Ukuphucula ukusebenza kakuhle kwamachiza okulwa nomhlaza.

Izigulo zomhlaza kunye nokufa kwabantu kuhlala kuphezulu, kwaye amayeza aphuhliswe ukunyanga umhlaza ahlala eneziphumo ebezingalindelekanga ezinamandla.Kunyango lomhlaza, ukongeza ekusebenziseni amachiza okulwa nomhlaza, amayeza ahlukeneyo acinezela iziphumo zawo ebezingalindelekanga kufuneka asetyenziswe ngaxeshanye.I-Theanine ngokwayo ayinayo umsebenzi wokuchasana ne-tumor, kodwa inokuphucula umsebenzi wamachiza ahlukeneyo e-anti-tumor.Xa i-theanine kunye ne-anti-tumor amachiza esetyenziswa kunye, i-theanine inokuthintela amayeza e-anti-tumor ukuba aphume kwiiseli zethumba kwaye iphucule isiphumo sokuchasa umhlaza samachiza achasene nethumba.I-Theanine inokunciphisa imiphumo emibi yezidakamizwa ze-antineoplastic, ezifana nokulawula inqanaba le-lipid peroxidation, ukunciphisa imiphumo emibi njengokunciphisa iiseli ezimhlophe zegazi kunye neeseli zethambo ezibangelwa ngamachiza e-antineoplastic.I-Theanine nayo inefuthe lokuthintela ukungena kweeseli zomhlaza, eyona ndlela iyimfuneko yokuba iiseli zomhlaza zisasazeke.Ukuthintela ukungena kwawo kunqanda ukusasazeka komhlaza.

(9) Isiphumo sokunciphisa umzimba

Njengoko sonke siyazi, ukusela iti kunefuthe lokunciphisa umzimba.Ukusela iti ixesha elide kwenza abantu babhitye kwaye basuse amanqatha abantu.Isiphumo sokuncipha kobunzima beti sisiphumo sentshukumo edibeneyo yamacandelo ahlukeneyo eti, kubandakanya i-theanine, eneneni esebenzayo ekunciphiseni i-cholesterol emzimbeni.Ukongeza, i-theanine ifunyenwe inokukhusela isibindi kunye neziphumo ze-antioxidant.Ukhuseleko lwe-theanine lubonakalisiwe.

(10) Isiphumo sokulwa nokudinwa

Uphononongo lufumene ukuba i-theanine ineziphumo ezichasene nokudinwa.Ukulawulwa komlomo kweedosi ezahlukeneyo ze-theanine kwiigundane iintsuku ezingama-30 kunokwandisa kakhulu ixesha lokubhukuda elithwala ubunzima beempuku, ukunciphisa ukusetyenziswa kwesibindi se-glycogen, kunye nokunciphisa inqanaba le-serum urea nitrogen ebangelwa ukuzivocavoca;inefuthe elibalulekileyo ekwandeni kwe-lactate yegazi kwiimpuku emva kokuzivocavoca.Inokukhuthaza ukupheliswa kwe-lactate yegazi emva kokuzivocavoca.Ke ngoko, i-theanine inefuthe lokudinwa.Indlela enokuthi ihambelane naloo theanine inokuthintela ukukhutshwa kwe-serotonin kwaye ikhuthaze ukukhutshwa kwe-catecholamine (i-5-hydroxytryptamine inempembelelo yokuthintela kwi-system ye-nervous central, ngelixa i-catecholamine inefuthe lokuvuselela).

(11) Ukuphucula ukukhuseleka komntu

Uvavanyo olugqitywe kutshanje yiYunivesithi yaseHarvard eUnited States lubonise ukuba iti eluhlaza, iti ye-oolong kunye neemveliso zeti ziqulethe i-concentration ephezulu yamaqela e-amino, anokuphucula amandla okusebenza kweeseli zokhuselo lomzimba kunye nokwandisa amandla omzimba womntu wokuxhathisa izifo ezosulelayo.

Ukusetyenziswa kwe-theanine kwintsimi yokutya

Kwango-1985, i-US Food and Drug Administration yaqaphela i-theanine kwaye yaqinisekisa ukuba i-theanine yokwenziwa yaziwa ngokubanzi njengento ekhuselekileyo (GRAS), kwaye akukho sithintelo kubungakanani bokusetyenziswa ngexesha lokusetyenziswa.

(1) Izongezo zokutya ezisebenzayo: I-Theanine inemisebenzi yokuphucula ukuqina kwamaza e-alpha engqondweni, okwenza abantu bazive bekhululekile kwaye baphucule imemori, kwaye iphumelele izilingo zabantu.Ke ngoko, inokongezwa ekutyeni njengesithako esisebenzayo ukuphuhlisa ukutya okusebenzayo okuphelisa uxinzelelo lwe-nervous kunye nokuphucula ubukrelekrele.Uphononongo lukwaqinisekisile ukuba i-theanine inokongezwa kwilekese, iziselo ezahlukahlukeneyo, njl.njl. ukufumana isiphumo esihle sokuthoba.Okwangoku iJapan iqhuba ngenkuthalo umsebenzi wophando kunye nophuhliso kule ndawo.

(2) Umphuculi womgangatho weziselo zeti

I-Theanine yeyona nto iphambili kwincasa entsha nehlaziyayo yeti, enokuthi ithintele ubukrakra becaffeine kunye nobukrakra beti polyphenols.Okwangoku, ngenxa yokuthintelwa kwezinto ezisetyenziswayo kunye neteknoloji yokulungisa, incasa entsha nehlaziyayo yeziselo zeti kwilizwe lam imbi.Ke ngoko, kwiziselo zeti Ukongeza inani elithile le-theanine ngexesha lenkqubo yokukhula kunokuphucula kakhulu umgangatho kunye nencasa yeziselo zeti.Isiselo "seti ekrwada" esandula ukwenziwa yiNkampani yaseJapan yaseKirin yongezwa kunye netheanine, kwaye impumelelo yaso enkulu kwimarike yesiselo saseJapan ngumzekelo oqhelekileyo.

(3) Umphumo wokuphucula incasa

I-Theanine ayinakusetyenziswa kuphela njenge-flavour modifier yeti eluhlaza, kodwa inokuthintela ubukrakra kunye ne-astringency kwezinye ukutya, ukuze kuphuculwe incasa yokutya.Iziselo ze-cocoa kunye neti ye-barley zinencasa ekhethekileyo ekrakra okanye e-spicy, kwaye i-sweetener eyongeziweyo inencasa engathandekiyo.Ukuba i-0.01% ye-theanine isetyenziselwa ukutshintsha i-sweetener, iziphumo zibonisa ukuba i-flavour yesiselo esongezelelweyo nge-theanine ingaphuculwa kakhulu.yokuphucula.

(3) Izicelo kwezinye iinkalo

I-Theanine ingasetyenziswa njengesicoci samanzi ukucoca amanzi okusela;Ukusetyenziswa kwe theanine njengesithako esisebenzayo kwisisusa-vumba kuye kwaxelwa kumalungelo awodwa omenzi wechiza waseJapan.Enye i-patent inika ingxelo yokuba into equlathe icandelo le-theanine inokuthintela ukuxhomekeka ngokweemvakalelo.I-Theanine isetyenziswa njenge-moisturizer kwi-cosmetics nanjengokutya okuthambisa ulusu.