L-Tryptophan Cas: 73-22-3 99% Umgubo omhlophe
| Inombolo Yekhathalogu | XD90295 |
| Igama lemveliso | L-Tryptophan |
| CAS | 73-22-3 |
| Ifomula yeemolekyuli | I-C11H12N2O2 |
| Ubunzima beMolekyuli | 204.22518 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29339980 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% min |
| Imbonakalo | Umgubo omhlophe |
| IBanga | USP32 |
| Ukujikeleza okuthe ngqo | -29.4 ukuya -32.8 |
| pH | 5.5 ukuya ku-7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Ilahleko ekomisweni | <0.3% |
| Intsalela kwi-Ignition | 0.1% ubuninzi |
| Cl | 0.05% ubuninzi |
I-Indoleamine 2,3-dioxygenase (IDO1) kunye ne-tryptophan 2,3-dioxygenase (TDO) zimbini ze-enzymes ezihlukeneyo ezihlukeneyo ezinokusabalalisa kwezicubu kunye neendima zomzimba, kodwa zombini zikhuthaza ukuguqulwa kwe-tryptophan kwi-N-formylkynurenine (NFK).I-IDO1 iye yaqinisekiswa ngokweklinikhi njenge-molekyuli encinci ekujoliswe kuyo kwichiza lomhlaza, ngelixa izifundo ze-preclinical zibonisa ukuba i-TDO inokuba yinto ekujoliswe kuyo kumhlaza we-immunotherapy kunye nesifo se-neurodeergenerative.Siye saphuhlisa i-high-throughput screening assay ye-IDO1 kunye ne-TDO esekelwe kwi-novel chemical probe, i-NFK Green, ephendula ngokuthe ngqo kunye ne-NFK ukwenza i-molecule ye-fluorescent eluhlaza kunye ne-excitation wavelength ye-400 nm kunye ne-emission wavelength ye-510 nm.Sibonelela ngecala lokuqala lokuthelekisa inani lee-inhibitors ezipapashiweyo ze-IDO1 kunye ne-TDO kwaye sityhila ukuba i-preclinical IDO1 inhibitor Compound 5l ibonisa ukuguqulwa okubalulekileyo kwe-TDO, ngelixa ukukhethwa okuhambelanayo kwezinye ii-inhibitors ezipapashwe kwaqinisekiswa.I-suitabil ity yokuhlolwa kwe-high-throughput ye-assays yaboniswa ngokuhlolwa kwelayibrari ye-87,000 yezinto zekhemikhali kwi-384- okanye i-1536-ifomathi yequla.Okokugqibela, sibonisa ukuba uvavanyo lunokusetyenziselwa ukulinganisa umthamo weeseli zokusebenzisa i-tryptophan kunye nokulinganisa amandla eselula e-IDO1 kunye ne-TDO inhibitors.
