Iimveliso

I-N-(2-Fluorophenyl) i-piperazine hydrochloride, eyaziwa ngokuba yi-2-fluorophenylpiperazine hydrochloride, ikhemikhali yekhemikhali esetyenziswa ngokuqhelekileyo kuphando lwamachiza kunye nophuhliso.Idlala indima ebalulekileyo njengendawo ephakathi ekudibaneni kweemolekyuli ezahlukeneyo ze-bioactive kunye namachiza axutywe namachiza.Enye yezicelo ezibalulekileyo ze-N-(2-Fluorophenyl) ipiperazine hydrochloride kukusetyenziswa kwayo kumachiza amayeza.Isebenza njengebhloko yokwakha ekudaleni iimolekyuli zamachiza ezinoveli ezineempawu ezithile.Ngokubandakanya i-2-fluorophenylpiperazine moiety kwisakhiwo sechiza, abaphandi banokuguqula iimpawu zayo kwaye baphucule ukudibanisa kunye nokukhetha kwabo bamkeli abathile.Oku kuvumela ukuphuhliswa kweziyobisi ezenziwe ngokwezifiso kunye neeprofayili eziphuculweyo ze-pharmacological zokusetyenziswa kwonyango.N-(2-Fluorophenyl) piperazine hydrochloride isoloko isetyenziswa kwi-synthesis ye-central nervous system (CNS) iziyobisi.Inobudlelwane bezamkeli ezahlukeneyo kwi-CNS, kubandakanya i-serotonin kunye ne-dopamine receptors.Le propathi iyenza ibe sisixhobo esixabiseke kakhulu sokufunda ukuphazamiseka kwemithambo-luvo kunye nengqondo.Ngokuphonononga ukusebenzisana phakathi kwale khompawundi kunye ne-receptors, abaphandi bafumana ukuqonda kwiindlela eziphantsi kwezi meko.Olu lwazi lunokuba negalelo ekuphuhliseni unyango olusebenzayo ngakumbi kunye namayeza okuphazamiseka okunjengokudakumba, i-schizophrenia, kunye nokuxhalaba.Ngaphezu koko, i-N-(2-Fluorophenyl) ipiperazine hydrochloride iphandiwe ngokukwazi kwayo njenge-analgesic, okanye i-agent yokunciphisa intlungu. .Ibonise iziphumo ezithembisayo kwizifundo ezahlukeneyo, ebonisa ukusetyenziswa kwayo okunokwenzeka ekuphuhliseni iziyobisi ze-analgesic.Ubume bayo beekhemikhali obukhethekileyo buvumela ukuguqulwa kunye nokuphucula ukunyusa umsebenzi walo we-analgesic kunye nokunciphisa iziphumo ezinokuthi zibe khona.Kubalulekile ukuphatha i-N-(2-Fluorophenyl) i-piperazine hydrochloride ngononophelo kwaye ubambelele kwiiprothokholi zokhuseleko ezifanelekileyo.Ukuqhelana namaphepha eenkcukacha zokhuseleko kunye nokusetyenziswa kwezixhobo ezifanelekileyo zokukhusela kubalulekile ukuqinisekisa ukuphathwa ngokukhuselekileyo kunye nokunciphisa nayiphi na imingcipheko enokubakho ehambelana nale khompawundi.Indima yayo ephakathi kwi-synthesis yeziyobisi ivumela ukudala amayeza alungelelanisiweyo aneempawu eziphuculweyo ze-pharmacological.Ubudlelwane bayo be-CNS receptors buququzelela ukufundwa kweengxaki ze-neurological and psychiatric, ngelixa iipropati zayo ezinokuthi zibe ne-analgesic ziyenza ibe ngumviwa wokuphuhliswa kweziyobisi ezidambisa iintlungu.Amanyathelo okhuseleko afanelekileyo kufuneka alandelwe ukuqinisekisa ukuphathwa ngokukhuselekileyo kwale khompawundi.