Iimveliso

I-N-(5-bromo--[1,3]thiazolo[4,5-b]pyridin-2-yl) benzamide yikhemikhali yekhemikhali enezicelo ezinokubakho kuphando lwamachiza, ngakumbi ekuphuhliseni amachiza amatsha.Isakhiwo sayo esiyingqayizivele se-molecular equkethe i-thiazolo [4,5-b] pyridine kunye ne-benzamide moieties inikezela ngamathuba okusetyenziswa kwamayeza ahlukeneyo.Enye yezinto eziphambili zokusetyenziswa kwe-N-(5-bromo-[1,3] thiazolo[4,5-b) ]pyridin-2-yl)benzamide ifana ne-pharmacophore, uphawu oluphambili lwesakhiwo olusebenzisana neethagethi zebhayoloji emzimbeni.Ubukho be-thiazolo [4,5-b] i-pyridine ring ivumela ukuba i-compound yenziwe njenge-ligand enokubakho kwaye ibophe kwiithagethi ezithile, ezifana ne-receptors okanye i-enzymes, echaphazelekayo kwiinkqubo zezifo ezahlukeneyo.Ngokuguqula i-substituents kwi-thiazolo [4,5-b] pyridine ring okanye iqela le-benzamide, izazinzulu ziyakwazi ukulungelelanisa ukusebenzisana kwe-compound ukujolisa kwiindlela ezithile okanye izifo.Le khompawundi inokusebenza njengesiqalo sokudityaniswa kunye nokuphucula iikhompawundi ezikhokelayo kwiinkqubo zokufunyanwa kweziyobisi.Ngaphezu koko, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide ingasetyenziswa kwizifundo zobudlelwane bomsebenzi wolwakhiwo (SAR).Ngokwenza izinto eziphuma kuzo kunye nee-analog zale khompawundi, abaphandi banokuvavanya ukuba uhlengahlengiso olwahlukileyo luchaphazela njani umsebenzi walo webhayoloji kunye namandla.Olu lwazi lubalulekile kuyilo olunengqiqo lwabaviwa abatsha beziyobisi ngokusebenza okuphuculweyo kunye neziphumo ebezingalindelekanga ezincitshisiweyo. yl) benzamide inokufumana ukusetyenziswa kwibhayoloji yemichiza kunye nezifundo zokuchongwa ekujoliswe kuzo.Ingasetyenziselwa njengesixhobo sekhompawundi kwiimvavanyo zebhayoloji ukucacisa umsebenzi weenjongo ezithile kunye neendlela kwiinkqubo zeselula.Ngokufunda imiphumo yale ngqungquthela kwiinkqubo zeselula, izazinzulu zinokufumana ulwazi oluxabisekileyo kwiindlela ezisisiseko zezifo kwaye zikwazi ukuchonga iithagethi ezintsha zonyango.Ngaphezu koko, N-(5-bromo-[1,3] thiazolo[4,5-b) ]pyridin-2-yl)benzamide inokuqeshwa kuphando lwekhemistri yamayeza kuphuhliso lweearhente zokulwa nomhlaza.I-Thiazolo [4,5-b] i-pyridine derivatives ibonise isithembiso ekuvimbeleni iindlela ezahlukeneyo zomhlaza, ezifana neprotein kinases ebandakanyekayo ekukhuleni kweeseli kunye nokuphila.Ngokubandakanya ukutshintshwa kwe-bromine kunye neqela le-benzamide, amandla e-compound kunye nokukhetha njenge-agent ye-anticancer ingaphononongwa ngakumbi kwaye iphuculwe.Ngokufutshane, i-N-(5-bromo-[1,3] thiazolo [4,5-b] pyridin -2-yl)benzamide yikhompawundi exabisekileyo enezicelo ezinokubakho kuphando lwamayeza.Ubume bayo obukhethekileyo bubonelela ngamathuba oyilo kunye nokuhlanganiswa kweekhompawundi ezikhokelayo, izifundo ze-SAR, ukuchongwa okujoliswe kuyo, kunye nokuphuhliswa kwee-anticancer agents.Ukuguquguquka kwekhompawundi kunye nokubanakho ekufumaneni ichiza kuqaqambisa ukubaluleka kwayo ekuqhubeleni phambili icandelo lekhemistri yamayeza kunye negalelo layo elinokubakho kuphuhliso longenelelo olutsha lonyango.