iindaba

I-Neocuproine reagent i-reagent yokumisela ubhedu, i-crystal emhlophe okanye i-yellow-brown, iyacaphukisa.Isetyenziswa kakhulu njenge-reagent yokuzimisela kwe-cuprous, ukuzimisela kwe-photometric yobhedu, ukuzimisela kwe-ultra-micro sugar sugar;i-organic synthesis.I-Neocuproine hydrochloride monohydrate isetyenzisiwe ekulinganiseni ukunyibilika kobhedu kwi-Cu–Ni alloys kusetyenziswa indlela ye-colorimetric.Ikwasetyenziswe ekulungiseleleni isisombululo se-agent entsonkothileyo ekufundeni i-antioxidant umthamo assays kwiisampulu zebhayoloji ezisekwe kwiCu yokunciphisa izakhiwo.Ingasetyenziselwa njenge-precursor yokulungiswa kwe-neocuproine, isetyenziswe njenge-reagent yokuhlalutya ukumisela ubhedu kwiisampuli zokusingqongileyo usebenzisa ubuchule be-spectrophotometric.

Kutshanje, i-Eribulin ivunyiwe ukuba ithengiswe nguLawulo lweeMveliso zoNyango lweSizwe (i-NMPA) yelizwe lam kunyango lwezigulana zomhlaza webele eziphindaphindayo okanye eziye zafumana ubuncinci ichemotherapy ezimbini. iirejimeni (kubandakanywa i-anthracyclines kunye neerhafu) kwixesha elidlulileyo.Izise iphethini entsha yonyango kwicandelo le-chemotherapy yomhlaza wamabele e-China, ikwazisa iindlela zonyango ezingakumbi kwizigulana.
I-Eribulin yi-non-taxane tubulin inhibitor.Ngokungafani ne-taxane kunye ne-vinblastine tubulin inhibitors, i-Eribulin inendlela ekhethekileyo yokusebenza, eyenza i-Eribulin isasebenza kwizigulane emva kokuchasana kweziyobisi kwi-yew;I-Eribulin nayo ineempembelelo ezingenayo i-cytotoxic, kubandakanywa ukulungiswa kwe-vascular, ukwandisa ukuchithwa kwamanye amachiza kwi-tumor microenvironment, i-synergizing ezinye iziyobisi, kunye nokuguqula iiseli ze-tumor I-epidermal-mesenchymal transition njalo njalo.

Ukususela kwi-synthesis ye-halichondrin B, ukusetyenziswa kwe-reagents entsha yobhedu njengama-intermediates, ukuguqulwa kwesakhiwo se-Eribulin, ukuveliswa kwemveliso ye-Eribulin, izazinzulu ezivela kwi-academia kunye neenkampani zonyango ziye zachitha iminyaka engaphezu kwe-20 yokuhlola.Iimveliso zendalo eziphuma elwandle ziye zaba ziziyobisi ezinokunyanga umhlaza.Uphando kunye nophuhliso lwe-Eribulin kungenxa yokuba i-reagent entsha yobhedu iyimfuneko njengeyona nto iphakathi kwe-API yayo.I-reagent entsha yobhedu inendima enkulu njenge-pharmaceutical intermediate kunye ne-reagent yokucoca izixhobo eziphezulu.

Isakhiwo se-molecular ye-Eribulin iqulethe amaziko e-chiral angama-19, kwaye amanyathelo okudibanisa ade njengamanyathelo angama-62.Ukuza kuthi ga ngoku, i-Eribulin isathathwa lishishini njengelona chiza linzima kakhulu le-non-peptide eliveliswe yi-chemical synthesis ecocekileyo, kwaye inokubizwa ngokuba yiNtaba ye-Everest kwishishini le-chemical synthesis.
Uluhlu oluyimpumelelo lwe-Eribulin lubonisa ukuphakama okutsha iinkampani zamachiza ezinokufikelela kwi-chemical synthesis kunye nemveliso yemizi-mveliso.Ikwazisa ngakumbi ukuxilongwa kunye nezimvo zonyango kunye nokhetho koogqirha baseTshayina.Kuyathenjwa ukuba kuqeqesho lwezonyango lwexesha elizayo, iyeza elitsha le-chemotherapeutic i-Eribulin linokuzisa ithemba elitsha kwizigulana ezinomhlaza wamabele.