Iimveliso

INicotinamide Riboside inokusetyenziswa kuphononongo lwebhayoloji yegene circadian reprogramming transcriptome kwisibindi ezichongiweyo iindlela zokuguga kwimpuku.Ikwanyusa i-NAD+ kwi-cortex ye-cerebral kwaye inciphisa ukuwohloka kwengqondo kwimodeli ye-mouse ye-transgenic yesifo se-Alzheimer.

I-Nicotinamide adenine dinucleotide (NAD+) yi-coenzyme ebalulekileyo ethi, xa incitshiswe kwi-NADH, isebenze njenge-arhente yokunciphisa ukunikela ngee-electron ze-oxidative phosphorylation kunye ne-ATP synthesis kwi-mitochondria.I-NAD+ yi-cofactor ebalulekileyo yee-enzymes ezifana ne-sirtuins, i-ADP-ribosyltransferases (ARTs), kunye ne-Poly [ADP-ribose] iipolymerases (PARPs) kwaye isetyenziswa ngokuqhubekayo ngezi enzymes.Umlinganiselo we-NAD +/NADH yinxalenye ebalulekileyo yemeko ye-redox yeseli.(Verdin 2015).Ngamanani athile, i-NAD okanye i-NADP ehambelana nayo ithatha inxaxheba kwikota yazo zonke ii-reactions zeselula (Opitz Heiland 2015).Kukho amacandelo ahlukeneyo e-NAD + kwi-nucleus, mitochondria, kunye ne-cytoplasm (Verdin 2015).
I-Nicotinamide riboside (NR) inokuguqulwa ibe yi-NAD+ ngenyathelo eliphakathi apho iguqulwa ibe yi-nicotinamide mononucleotide (NMN) ngu-NR kinase (Nrk) kwaye emva koko kwi-NAD+ nge-NMNATs.I-NR ifumaneka ngokwendalo kokunye ukutya kodwa kwizixa ezisezantsi kakhulu (umz. uluhlu oluphantsi lwe-micromolar).Ngokwembali, i-NR yayinzima ukuyifumana kwiimali ezinkulu ezihlanjululweyo, kodwa ngenxa yenkqubela phambili kwiindlela zokudibanisa (i-Yang 2007), ukususela ngoJuni 2013, ithengiswa njengesongezo sokutya.