I-Phosphatase, i-alkaline CAS: 9001-78-9 emhlophe, emhlophe engwevu okanye i-peach monoclinic crystal okanye umgubo
| Inombolo Yekhathalogu | XD90379 |
| Igama lemveliso | I-Phosphatase, i-alkaline |
| CAS | 9001-78-9 |
| Ifomula yeemolekyuli | I-C21H36N8O6 |
| Ubunzima beMolekyuli | 496.57 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 35079090 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | ezimhlophe, ezingwevu ezimhlophe okanye ipesika monoclinic crystal okanye umgubo |
Nangona i-fluoride iyaziwa ngokuvuselela ukubunjwa kwamathambo, iindlela ezisisiseko aziqondwa ngokupheleleyo.Uphononongo lwakutsha nje luchaphazele indlela ye-Wnt/β-catenin njengophawu olukhulu lwebhayoloji yethambo.Uphononongo lwethu lwangaphambili luqaqambise indima enokwenzeka ye-canonical Wnt pathway ekwakhiweni kwamathambo eempuku ezinganyangekiyo ezivezwe ngefluoride, kodwa indlela yokusebenza ihlala ingacacanga.Uphononongo lwangoku lunqume ukubandakanyeka kwe-Wnt / β-catenin yokubonisa kwi-fluoride-induced osteoblastic differentiation.Sisebenzisa i-osteoblasts yeempuku eziphambili, sibonise ukuba i-fluoride ikhuthaza kakhulu ukwanda kwe-osteoblasts kunye ne-alkaline phosphate (ALP) ibinzana kunye namanqanaba okubonakaliswa kwe-mRNA yeempawu zokwahlula amathambo, kuquka uhlobo lwe-collagen (COL1A1), i-ALP kunye ne-osteonectin.Siphinde safumana i-fluoride induced phosphorylations kwi-serine 473 ye-Akt kunye ne-serine 9 ye-glycogen synthase kinase-3β (GSK3β), eyabangela ukuba i-GSK-3β inhibition kwaye emva koko ukuqokelelwa kwenyukliya kwe-β-catenin, njengoko kuboniswe yi-Western blot kunye ne-immunofluoresce .Ngaphezu koko, i-fluoride ikwaphembelele intetho ye-Wnt-targeted gene run-related transcription factor 2 (Runx2).Okubalulekileyo, umphumo omuhle we-fluoride kumsebenzi we-ALP kunye neenkcazo ze-mRNA ze-COL1A1, i-ALP, i-osteonection kunye ne-Runx2 yapheliswa ngu-DKK-1, i-blocker ye-Wnt / β-catenin receptor.Kuthatyathwe kunye, ezi ziphumo zibonisa ukuba i-fluoride ikhuthaza ukuhlukana kwe-osteoblastic ngokusebenzisa i-Akt- kunye ne-GSK-3β-exhomekeke kwi-activation ye-Wnt / β-catenin indlela yokubonakalisa i-osteoblasts ye-rat.Iziphumo zethu zibonelela ngombono wenoveli kwiindlela zesenzo se-fluoride kwi-osteoblastogenesis.
