Iplatinam kwikhabhoni esebenzayo Cas: 7440-06-4
| Inombolo Yekhathalogu | XD90696 |
| Igama lemveliso | Iplatinam kwikhabhoni esebenzayo |
| CAS | 7440-06-4 |
| Ifomula yeemolekyuli | Pt |
| Ubunzima beMolekyuli | 195.08 |
| Iinkcukacha zokuGcina | 2-8°C |
| IKhowudi yoMrhumo eHarmonized | 28439000 |
Ukucaciswa kweMveliso
| Imbonakalo | silvery-grey meta |
| Isivavanyi | 99% |
| Damandla | 21.45 |
| Indawo yokunyibilika | 1772℃ |
| Indawo yokubilisa | 3827℃ |
| Refractive Index | n20/D 1.347 |
| Indawo yokuflasha | 3825°C |
| Uxinzelelo lomphunga | 0 mm Hg (malunga) (NIOSH, 2016) |
Ukuphonononga inoveli iplatinam-based anticancer agents ezahlukileyo kulwakhiwo kunye nemowudi yokunxibelelana ye-cisplatin yendabuko ngokwenza i-bifunctional intrastrand 1,2 GpG adduct, i-monofunctional platinum + DNA idducts kunye nobudlelwane obuninzi obungena-covalent iye yafundwa.Kwaxelwa ukuba i-agent esebenzayo ye-testosterone-based platinum (II) ibonisa umsebenzi ophezulu wokulwa nomhlaza.Ngaphaya koko, kwafunyaniswa ukuba ii-agent ezisekelwe kwi-testosterone-based platinam zinokubangela ukuba i-DNA helix ihambe ngokuphawulekayo kwaye igobe kwii-agent zeplatinam ezingezo-testosterone.Nangona kunjalo, iindlela zokusebenzisana kwezi arhente zeplatinum kunye ne-DNA kwinqanaba leathomu azikacaci okwangoku.Kulo msebenzi wangoku, sasebenzisa ukulinganisa kwe-molecular dynamics (MD) kunye nokubalwa kwe-DNA conformational dynamics calculations to study properties of DNA distortion of the testosterone- esekelwe kwiplatinum + DNA, i-testosterone-based platinum + DNA ephuculweyo kunye ne-non-testosterone-based platinum + DNA adducts.Iziphumo zibonisa ukuba intsebenziswano edibeneyo ye-agent ephuculweyo ye-testosterone-based platinam kunye ne-molecule ye-DNA inokubangela ukugqwesa okukhulu kwe-DNA conformational kunokuba i-groove-face interaction ye-agent eqinile ye-testosterone-based based platinam ene-molecule ye-DNA.Uphando olongezelelekileyo lwe-agent yeplatinam engeyiyo testosterone-based ityhila ukwenzeka kotshintsho olungabalulekanga lwe-DNA conformation ngenxa yokungabikho kwe testosterone ligand kwiarhente enjalo.Ngokusekelwe kuhlalutyo lwe-DNA dynamics, iziseko ze-DNA ezibhekiselele kwi-DNA groove iparameter utshintsho kunye nokutshatyalaliswa kwebhondi ye-hydrogen yezibini zesiseko se-DNA nazo zaxoxwa kulo msebenzi. i-testosterone-based based platinum + DNA adduct, eyahlukileyo kwi-groove-face interaction ebangelwa ukudibanisa okuqinileyo kwi-agent ye-platinum esekelwe kwi-testosterone.Uphando lwangoku lubonelela ngolwazi oluluncedo lwe-DNA conformation echaphazelekayo yi-testosterone-based based platinum complex kwinqanaba le-athomu.
