I-Pyridoxal-5'-phosphate monohydrate CAS: 41468-25-1 99% Ngaphandle-mhlophe ukuya kumgubo otyheli okhanyayo
| Inombolo Yekhathalogu | XD90390 |
| Igama lemveliso | I-Pyridoxal-5'-phosphate monohydrate |
| CAS | 41468-25-1 |
| Ifomula yeemolekyuli | C8H10NO6P·H2O |
| Ubunzima beMolekyuli | 265.16 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29362500 |
Ukucaciswa kweMveliso
| Iintsimbi ezinzima | 20ppm ubukhulu |
| Ubalo lweepleyiti lulonke | 1000 cfu/g max |
| E.Coli | Ibi |
| Salmonella | Ibi |
| Ilahleko ekomisweni | 10.0% ubukhulu |
| Staphylococcus aureus | Ibi |
| Isivavanyi | 99% |
| Imbonakalo | Okumhlophe-mhlophe ukuya kumgubo otyheli okhanyayo |
| Igwele kunye neMold Count | 100 cfu/g max |
| Umhla wokwenziwa | TBC |
| I-Coliform | Ibi |
| IPyridoxine (HPLC) | 0.01 % ubukhulu |
| PH(0.25% ag Solution) | 2.6-3.0 |
Ukulungiswa okuphumelelayo kwe-myelin kwi-CNS yabantu abadala kufuna ukuveliswa okuqinileyo kunye nexesha elifanelekileyo leeprotheni ze-myelin ukuvelisa i-myelin sheaths entsha.Iindlela ezisisiseko zokulawula kunye nesiseko semolekyuli eyinkimbinkimbi yokuvuselelwa kwe-myelin, nangona kunjalo, zihlala zingaqondwa kakuhle.Apha, siphanda indima ye-ERK MAP kinase yokubonisa kule nkqubo.Ukucinywa ngokwemiqathango kwe-Erk2 kwiiseli zomnombo we-oligodendrocyte kubangele ukulibaziseka kwe-remyelination kulandela ukwenzakala okuthomalalisayo kwi-corpus callosum yempuku yabantu abadala.Ukulungiswa okulibazisekayo kwenzeka ngenxa yentsilelo ethile ekuguquleleni iprotheni enkulu ye-myelin, i-MBP.Ukungabikho kwe-ERK2, ukusetyenziswa kweprotheyini ye-ribosomal S6 kinase (p70S6K) kunye nethagethi yayo ephantsi, i-ribosomal protein S6 (S6RP), yayiphazamisekile ngexesha elibalulekileyo xa i-premyelinating oligodendrocytes iguqulela kwiiseli ezivuthiweyo ezikwazi ukuvelisa i-myelin sheaths entsha.Ngaloo ndlela, siye sachaza ikhonkco elibalulekileyo phakathi kwe-ERK MAP kinase yokubonisa i-cascade kunye noomatshini be-tra nslational ngokukodwa kwi-oligodendrocytes e-remyelinating kwi-vivo.Ezi ziphumo zibonisa indima ebalulekileyo ye-ERK2 kulawulo lokuguqulela lwe-MBP, iprotheni ye-myelin ebonakala ibaluleke kakhulu ekuqinisekiseni ukuveliswa kwexesha leeshethi ze-myelin ezitsha emva kokulimala kwe-demyelinating kwi-CNS yabantu abadala.
