Iimveliso

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine yinkomponi ye-chiral kunye nezicelo ezahlukeneyo kwintsimi yamachiza.Isicelo esinye esibalulekileyo se-(S)-(-) -N, N-Dimethyl-3-hydroxy-3- (2-thienyl) ipropanamine ekuphuhlisweni kwe-serotonin reuptake inhibitors (SSRIs) ekhethiweyo.I-SSRIs ludidi lweziyobisi eziqhele ukusetyenziswa ukunyanga uxinzelelo, ukuphazamiseka kokuxhalaba, kunye nezinye iimeko zempilo yengqondo.Le ngqungquthela isebenza njenge-precursor okanye i-start material kwi-synthesis ye-serotonin reuptake inhibitors ekhethiweyo, evumela ukuphuhliswa kwee-enantiomers ezithile kunye neempawu zonyango eziphuculweyo.Ngokudibanisa (S) - (-)-N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine kwisakhiwo sesiyobisi, abaphandi banokuhlengahlengisa iimpawu zayo ze-pharmacological, ezifana nobudlelwane bayo nabathuthi be-serotonin, kubangele ukusebenza okuphuculweyo kunye nokunciphisa iziphumo zecala.Ukongezelela, (S) - (-) -N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine ingasetyenziselwa njengebhloko yokwakha kwi-synthesis yezinye izinto eziphilayo. iikhompawundi.Ubume bayo be-chiral kunye nolwakhiwo oluguquguqukayo luyenza ibe sisixhobo sokuqala esixabisekileyo sokwakhiwa kweemolekyuli ezinzima.Abaphandi banokusebenza kwiindawo ezahlukeneyo kwimolekyuli ukwazisa amaqela ahlukeneyo okanye ukuguqula i-stereochemistry yayo ukudala abaviwa iziyobisi ezinoveli.Ngaphezu koko, (S) -(-)-N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine ifundwe ngokusetyenziswa kwayo kunyango lwesifo sikaParkinson.Uphando lubonise ukuba le khompawundi ibonisa umsebenzi we-dopamine agonist, oku kuthetha ukuba inokuvuselela i-dopamine receptors, ehlala ichaphazeleka kwisifo sikaParkinson.Inokuba namandla onyango ekunciphiseni iimpawu ezinxulumene nesi sifo se-neurodeergenerative.Kubalulekile ukuqaphela ukuba (S) - (-)-N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine inamandla i-compound, kwaye ukusetyenziswa kwayo kufuneka kuphathwe ngononophelo.Abaphandi kunye neengcali ezisebenza kunye nale khompawundi kufuneka zihambelane nezikhokelo zokhuseleko kunye neenkqubo zokuqinisekisa ukuphathwa ngokufanelekileyo kunye nokunciphisa umngcipheko. ) ipropanamine yinto exabisekileyo ekuphuhliseni i-serotonin reuptake inhibitors ekhethiweyo kunye nezinye iamolekyu ze-bioactive.Ubume bayo be-chiral, ulwakhiwo oluguquguqukayo, kunye nemisebenzi yonyango enokubakho iyenza ibe yibhloko ebalulekileyo yokwakha kuphando lwamayeza.Uphononongo oluqhubekayo kunye nokuhlolwa kwe-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine inokufaka isandla ekuphuhliseni iziyobisi ezinoveli kunye nonyango olunokubakho kwiingxaki ezahlukeneyo.