Iimveliso

Impembelelo yeetyhubhu ze-endotracheal (ETTs) ezifakwe kwi-chlorhexidine (CHX) kunye nesiliva carbonate (i-antiseptic ETTs) ngokuchasene ne-Staphylococcus aureus, i-methicillin-resistant S. aureus (MRSA), i-Pseudomonas aeruginosa, i-Acinetobacter baumannii, kunye ne-Engenesgenes-aerorganiter inyumoniya enxulumene (VAP)], yavavanywa kwimodeli yomoya welabhoratri.I-ETTs ze-Antiseptic kunye ne-ETTs zokulawula (ezingabonakaliyo) zifakwe kwiityhubhu zenkcubeko ezizaliswe isiqingatha se-agar media (imodeli ye-airway) ngaphambili eyayingcoliswe phezulu kunye ne-10 (8) cfu / mL yezinto ezikhethiweyo zovavanyo.Emva kweentsuku ezintlanu ze-incubation, ukubalwa kwekholoni yebhaktiriya kuwo onke amacandelo e-ETT anqunywe.I-Swabs ye-proximal kunye neziphelo ezikude ze-agar tract kwi-antiseptic kunye neemodeli zokulawula zaye zafakwa kwi-subcultured.Amanqanaba okuqala kunye nentsalela ye-CHX, (iintsuku ezintlanu emva kokufakelwa kwimodeli) zagqitywa.Iinkcubeko ze-ETT ze-antiseptic zibonakalise i-colonization ngama-pathogens avavanyiweyo ukusuka kwi-1-100 cfu / ityhubhu, xa kuthelekiswa ne-10 (6) cfu / ityhubhu yolawulo lweETTs (P <0.001).I-Subcultures esuka kwii-proximal kunye neziphelo ezikude ze-agar tract ibonise ukukhula okuncinci okanye akukho kukhula kwi-ETT ye-antiseptic xa kuthelekiswa ne-ETTs yokulawula (P <0.001).Isixa se-CHX esigcinwe kwi-ETTs ye-antiseptic emva kweentsuku ezintlanu zokufakelwa kwakuyi-avareji ye-45% yenqanaba lokuqala.I-ETTs ze-Antiseptic zithintele ikholoni yebhaktheriya kwindlela yomoya kwaye iphinde igcine ixabiso elibalulekileyo le-antiseptic.Ezi ziphumo zibonisa ukuba ukusebenza kwe-ETTs efakwe kwi-antiseptic ekukhuseleni ukukhula kwentsholongwane ye-bacterial ehambelana ne-VAP inokwahluka kunye neentlobo ezahlukeneyo zezinto eziphilayo.Copyright 2004 I-Hospital Infection Society