Iimveliso

I-T-Butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate yikhemikhali edibeneyo kunye nesakhiwo esiyinkimbinkimbi esisetyenziswa ngokuqhelekileyo kwi-organic synthesis kunye neqela elikhuselayo kwi-carbohydrate chemistry.Iyaziwa ngokukwazi ukukhusela ngokufanelekileyo amaqela e-hydroxyl kunye nokuthintela ukuphendulwa okungafunekiyo ngexesha lokuguqulwa kweekhemikhali ezahlukeneyo.Enye yezinto eziphambili zokusetyenziswa kwe-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- I-dihydroxyhexanoate ikwi-synthesis ye-complex organic compounds.Amaqela e-Hydroxyl asebenza kakhulu kwaye anokufumana iimpendulo ezingafunekiyo ngexesha lokuguqulwa kweekhemikhali.Ngokukhusela ngokukhethekileyo la maqela kunye ne-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, i-chemist inokulawula ukusabela kunye nokufumana iimveliso ezifunwayo.Emva kokuba ukuguqulwa kweekhemikhali ezifunwayo kugqityiwe, iqela elikhuselayo linokususwa ngokulula, livumela ukubuyiswa kwamaqela e-hydroxyl yasekuqaleni.Kwi-carbohydrate chemistry, i-T-butyl- (3R,5S) -6-hydroxy 3,5-O-isopropylidene I-3,5-dihydroxyhexanoate isetyenziswa ngokuqhelekileyo ukukhusela iimolekyuli zeswekile.Iswekile inamaqela amaninzi e-hydroxyl anokusabela kwii-reagents, ezikhokelela kwiimveliso ezingafunekiyo.Ngokukhusela ngokukhethekileyo la maqela e-hydroxyl kunye ne-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, iikhemikhali ziyakwazi ukuxhaphaza amaqela asele e-hydroxyl ngaphandle kokuphazamiseka.Oku kuvumela ukuhlanganiswa kweemveliso zeswekile eziyinkimbinkimbi kunye nokufunda ukusebenzisana kwe-carbohydrate-protein okanye ukuhlanganiswa kwe-glyccoconjugates.Ngaphezu koko, i-T-butyl- (3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- Iqela elikhuselayo le-dihydroxyhexanoate lihlala lisetyenziswa ngexesha lokwenziwa kweemveliso zendalo, amayeza, kunye nezinye izinto eziphilayo ezisebenzayo.Ukukhuselwa kwayo ngokufanelekileyo kunye neempawu zokukhusela zenza ukuba iikhemisti zikwazi ukufikelela kuluhlu olubanzi lweeamolekyu ezihlukeneyo.Ukukhuselwa kwamaqela athile e-hydroxyl kunceda ekulawuleni iindlela zokusabela kunye nokufezekisa i-regioselectivity efunwayo okanye i-stereoselectivity.Ekuqukumbeleni, i-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate Ikhompawundi eguquguqukayo esetyenziswa ngokubanzi kwimichiza yokwenziwa kwezinto eziphilayo, ngakumbi kukhuseleko kunye nokukhuselwa kwamaqela e-hydroxyl.Ubume bayo obukhethekileyo buvumela ukukhuselwa okukhethiweyo, okwenza ukuba iikhemisti zilawule ukuphendula kunye nokufumana iimveliso ezifunwayo.Izicelo zayo zivela kwi-synthesis ye-complex organic compounds ukuya kwi-carbohydrate chemistry kunye nokuveliswa kweemveliso zendalo kunye namayeza.Ikhono lekhompawundi lokukhusela amaqela e-hydroxyl ngokufanelekileyo liyenza ibe sisixhobo esixabiseke kakhulu kwimiba eyahlukeneyo yophando lwekhemikhali nophuhliso.