Iimveliso

I-Tetrabenzyl Dapagliflozin yikhemikhali ephuma kwi-Dapagliflozin, eliyeza elithathwa ngomlomo eliboniswa kunyango lwe-2 yesifo seswekile.I-Tetrabenzyl I-Dapagliflozin yi-derivative ye-Dapagliflozin kwaye ibonise amandla ekwandiseni iziphumo zayo zonyango.I-Dapagliflozin yi-sodium-glucose cotransporter 2 (SGLT2) inhibitor esebenza ngokuthintela ukubuyiswa kwakhona kwe-glucose kwizintso, ekhokelela ekunyuseni kwe-urinary reduction kunye nokunciphisa umchamo jikelele. kumanqanaba eglucose egazini.Eyona nto isetyenziselwa ukuphucula ukulawulwa kwe-glycemic kwizigulane ezinesifo sikashukela sohlobo lwe-2. I-Tetrabenzyl Dapagliflozin, njenge-derivative ye-Dapagliflozin, iye yaphuhliswa ukuze ikwazi ukuphucula iimpawu ze-pharmacokinetic kunye nokusebenza kwekhompawundi yokuqala.Ibonisa iindlela ezifanayo zesenzo, inqanda i-SGLT2 kwizintso, kodwa ngolunye uhlengahlengiso kwisakhiwo sayo se-molecular.Enye inzuzo enokubakho yeTetrabenzyl Dapagliflozin ngaphezu kweDapagliflozin kukunyuka kozinzo kunye nokunyibilika kwayo.Ukongezwa kwamaqela e-benzyl kwisakhiwo kwandisa iimpawu zayo zomzimba, okwenza ukuba zizinzile kwaye zinyibilike kwiindawo ezahlukeneyo.Oku kunyibilika okuphuculweyo kunokuphucula ukufunxa kunye ne-bioavailability yechiza emzimbeni.Ngaphezu koko, i-Tetrabenzyl Dapagliflozin ingaba nexesha elide lesenzo xa kuthelekiswa ne-Dapagliflozin.Ukuguqulwa kwesakhiwo sayo kunokuthi kunciphise i-metabolism kunye nokuphelisa, okukhokelela kwimpembelelo eqhubekayo kumanqanaba eglucose yegazi.Esi senzo sexesha elide sinokunikezela ngolawulo olungcono lwe-glycemic kunye nokunciphisa ukuphindaphinda kwe-dosing.I-Tetrabenzyl Dapagliflozin isekwinqanaba lokuqala lophando kunye nophuhliso, kwaye izifundo ezingaphezulu zifunekayo ukuze ziqonde ngokupheleleyo iinzuzo zayo zonyango ezinokuthi zibe khona.Ikhompawundi ibonisa isithembiso njengophuculo olunokubakho kwi-Dapagliflozin, kodwa uphando olongezelelweyo luyafuneka ukuze kuhlolwe ukusebenza kwayo, ukhuseleko, kunye nokusetyenziswa kwezonyango. Kubalulekile ukuqaphela ukuba ukusetyenziswa kweTetrabenzyl Dapagliflozin okanye nayiphi na ikhompawundi yoxubo kufuneka isoloko isenziwa phantsi kweliso. isikhokelo sokhathalelo lwempilo.Banokubonelela ngolwazi oluyimfuneko malunga nezibonakaliso zayo, i-dosing, imiphumo enokubakho, kunye nokusebenzisana namanye amayeza.