Iimveliso

I-Trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) i-pyrrolidine-3-carboxylic acid yikhemikhali yekhemikhali enezixhobo ezahlukeneyo ezinokubakho kwintsimi ye-organic synthesis kunye nophando lwamachiza.Ibonakaliswe kubukho bendandatho yepyrrolidine endaweni yeqela elikhuselayo le-tert-butoxycarbonyl (Boc) kwi-athomu ye-nitrogen kunye neqela le-trifluoromethyl kwindandatho ye-phenyl. I-4- (3- (trifluoromethyl) phenyl) i-pyrrolidine-3-carboxylic acid injenge-intermediate kwi-synthesis yezinye izinto eziphilayo.Ulwakhiwo lwalo olukhethekileyo kunye namaqela asebenzayo enza ukuba kube yinto eguquguqukayo yokwakha i-molecule eyinkimbinkimbi.Iqela le-Boc lisebenza njengeqela elikhuselayo, elinokuthi lisuswe ngokukhethiweyo phantsi kweemeko ezithile zokusabela ukuveza indawo esebenzayo ukuze kulungiswe ngakumbi.Oku kuvumela ukuguqulwa kwezinto eziphilayo ezilawulwayo nezichanekileyo.Iqela le-trifluoromethyl kwi-trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) i-pyrrolidine-3-carboxylic acid inika kwakhona iimpawu ezibalulekileyo kunye nokusetyenziswa okunokwenzeka.Amaqela e-Trifluoromethyl aziwa ngobume be-electron-withdrawing kunye ne-lipophilicity, enokuphucula amandla, ukuzinza kwe-metabolic, kunye ne-bioavailability yabagqatswa bamachiza.Ukongezelela, iqela le-trifluoromethyl liyakwazi ukulungelelanisa iimpawu ze-physicochemical zekhompawundi, ezichaphazela ukunyibilika, i-lipophilicity, kunye ne-receptor ebopha ubudlelwane. I-carboxylic acid inokubonisa umsebenzi webhayoloji ngokwayo okanye njengemveliso.Iimveliso ziyi-biologically inactive compounds ezityhubela ukuguqulwa kweekhemikhali okanye i-enzymatic emzimbeni ukuze ziguqulwe zibe ngamachiza asebenzayo.Kwezinye iimeko, iqela elikhuselayo le-Boc linokuthi lisuswe ngokukhethiweyo kwi-vivo, isebenze i-compound ukuze ifumane umphumo ofunekayo wonyango.Ngelixa izicelo ezithile kunye nokusetyenziswa okunokwenzeka kwe-trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl) phenyl)pyrrolidine-3-carboxylic acid zininzi, uphando olongezelelweyo kunye nophando luyimfuneko ukuhlola amandla ayo apheleleyo.Oku kubandakanya ukwenziwa ngcono kwekhemistri yezamayeza, izifundo zobudlelwane bolwakhiwo, kunye novavanyo lwebhayoloji.Ngokuqonda ngokucokisekileyo iipropathi zekhompawundi kunye nokusebenza kwakhona, izazinzulu zinokuvavanya ukufaneleka kwayo ukujolisa kwizifo okanye iimeko ezithile, ezikhokelela kuphuhliso lwabaviwa bamachiza anoveli okanye i-catalytic agents kwixa elizayo.