Iimveliso

I-Trifluoromethanesulfonic anhydride, eyaziwa njenge-triflic anhydride okanye i-Tf2O, sisixhobo esisebenza ngeendlela ezininzi esisetyenziswa ngokubanzi kwi-organic synthesis, ngakumbi kwibala le-synthetic chemistry.Yikhompawundi esebenza kakhulu esebenza iinjongo ezininzi ngenxa yeasidi eyomeleleyo kunye nokukwazi ukujongana neekhemikhali ezahlukeneyo zotshintsho.Enye yezinto eziphambili zokusetyenziswa kwe-triflic anhydride njenge-arhente yokuphelelwa ngamanzi emzimbeni.Isabela ngamandla kunye nee-alcohols, iguqulela kwii-ethers ezihambelanayo.Le ndlela yokusabela, eyaziwa ngokuba yiWilliamson ether synthesis, idla ngokusetyenziswa kwizicwangciso zaselabhoratri kunye neenkqubo zoshishino ukwenza iimolekyuli ezintsonkothileyo.I-Triflic anhydride iluncedo ngakumbi ekuguquleni utywala obuthintelweyo, obunokuthi bungakhawulezi ukusabela kunye nezinye ii-reagents, zibe yi-ethers ngokufanelekileyo.Ingasetyenziselwa ukukhusela amaqela asebenzayo abuthathaka, afana ne-alcohols kunye ne-amines, ngokwenza i-triflates ezinzileyo.Ezi triflates zinokukhutshelwa ngokukhethiweyo phantsi kweemeko ezifanelekileyo ukuvuselela amaqela asebenzayo afunwayo.Esi sicwangciso sibaluleke kakhulu kwi-multi-step synthesis, apho ukukhuselwa kunye nokukhuselwa kwamaqela asebenzayo kuyimfuneko ukufezekisa iimpendulo ezifunwayo ngokukhethiweyo.I-anhydride ye-Triflic iphinda ifumane isicelo njenge-catalyst kunye nomgqugquzeli kwiimpendulo ezahlukeneyo.I-asidi yayo ephezulu, ephuma kwi-trifluoromethanesulfonic acid eyenza phambi kwamanzi, iququzelela ukusabela kwe-asidi-catalyzed.Iyakwazi ukukhuthaza ukuguqulwa kwezinto ezahlukeneyo ezifana ne-esterifications, i-acylations, kunye nokuhlengahlengiswa kwakhona, okwenza ukuba ukuhlanganiswa kwee-molecule eziyinkimbinkimbi.Ngaphezu koko, i-triflic anhydride iqeshwe njenge-electrophile enamandla kwiimpendulo ezahlukeneyo.Inokusabela nge-nucleophiles ukwazisa amaqela e-triflyl (CF3SO2), asebenza ngeendlela ezahlukeneyo kwi-synthetic chemistry.Amaqela e-Triflyl asebenza njengamaqela ashiyayo alungileyo, evumela ukusabela okulandelayo okufana nokutshintshwa kwe-nucleophilic okanye ukulungiswa kwakhona. Ngaphandle kokusebenziseka kwayo, i-triflic anhydride kufuneka iphathwe ngononophelo ngenxa yendalo yayo eyingozi kakhulu kunye nokuphinda kusebenze kwakhona.Kufuneka kuthatyathwe amanyathelo afanelekileyo okhuseleko, kuquka ukusebenzisa iimpahla ezifanelekileyo zokuzikhusela, iiglavu, iimpahla zamehlo, nokusebenza kwindawo engenamoya.Ukongeza, ngenxa yobume bayo bokugqwala, kuyacetyiswa ukuba uphathe i-triflic anhydride phantsi kwe-inert atmosphere.Ngesishwankathelo, i-triflic anhydride yi-reagent exabisekileyo kwi-organic synthesis ngenxa yokukwazi ukusebenza njenge-agent ekhupha amanzi, i-agent ekhuselayo kunye ne-deprotectation ukuze isebenze. amaqela, i-catalyst, umgqugquzeli, kunye ne-electrophile.Ukuguquguquka kwayo kunye nokusebenza kwakhona kuyenza ibe yinxalenye yeenkqubo ezininzi zebhubhoratri kunye neenkqubo zoshishino, ezivumela ukuhlanganiswa okusebenzayo kwezinto ezahlukeneyo zezinto eziphilayo.Nangona kunjalo, kufuneka kulumke xa kusingathwa i-triflic anhydride, ngokubambelela kwiiprothokholi zokhuseleko ezifanelekileyo ukuqinisekisa impilo entle yekhemisti kunye nokuthintela iingozi elabhoratri.