Iimveliso

I-Nickel sisigqibo sobuntsholongwane kwi-pathogen yesisu somntu iHelicobacter pylori.Enyanisweni, i-H. pylori inezinto ezimbini ze-nickel-enzymes eziyimfuneko kwi-vivo colonization, [i-NiFe] i-hydrogenase kunye ne-urease, i-virulence factor eninzi equkethe i-24 ion nickel kwi-complex esebenzayo.Ngenxa yezi enzyme zimbini, ukusinda kwe-H. pylori kuxhomekeke ekuboneleleni okubalulekileyo kwe-nickel, oku kuthetha ukulawulwa okuqinileyo kokusasazwa nokugcinwa kwayo.Kolu hlaziyo, siya kubonisa iindlela zokusebenzisa i-nickel enzymes kunye neendlela zangaphambili ezifunyenwe kwi-H. pylori yokuthatha, ukurhweba kunye nokusabalalisa i-nickel phakathi kwee-enzyme ezimbini.Ezi ziquka (i) inkqubo yokuthatha i-nickel yangaphandle, i-FrpB4 TonB exhomekeke kwi-TonB, (ii) i-protein complexes edibeneyo kunye nothungelwano lokusebenzisana olubandakanyeka kurhwebo lwe-nickel kunye nokusabalalisa phakathi kwe-urease kunye ne-hydrogenase kunye, (iii) ne-Helicobacter i-nickel ethile-i-proteins ebopha i-nickel. ababandakanyekayo kwi-nickel yokugcina kwaye banokudlala indima ye-metallo-chaperones.Ekugqibeleni, siza kuxoxa ngempembelelo yamaqabane orhwebo lwe-nickel kwi-virulence kwaye sibacebise njengeethagethi zonyango ezinoveli kunyango oluchasene nosulelo lwe-H. pylori.