Iimveliso

1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester yi-compound yeekhemikhali eziyinkimbinkimbi ezibonise amandla kwiindawo ezahlukeneyo zekhemistri yamayeza kunye nokufunyanwa kweziyobisi.Nantsi inkcazo yokusetyenziswa kwayo malunga namagama angama-300. Le khompawundi, edla ngokubizwa ngokuba yi-ethyl ester derivative ye-1- (4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid, iphuma kwiklasi yepyrazolo [3,4-c] pyridine derivatives.Ezi mveliso ziye zatsala ingqalelo ekufumaneni iziyobisi ngenxa yesakhono sazo kwiindawo ezahlukeneyo zonyango.Enye isicelo esinokubakho kule khompawundi silele kwinkalo yophando oluchasene nomhlaza.I-Pyrazolo[3,4-c] i-pyridine derivatives ibonise umsebenzi othembisayo wokuchasana neentlobo ezininzi zeeseli zomhlaza.Ukukwazi kwabo ukuthintela iindlela ezithile ezibandakanyekayo ekukhuleni kwethumba kunye nokusinda kubenza babe ngabaviwa abanokuthi baphuhlise amachiza okulwa nomhlaza.Uphononongo olongezelelweyo lufunekayo ukuphonononga indlela yokusebenza kunye nokuvavanya ukusebenza kwekhompawundi kwimimiselo yangaphambi kweklinikhi kunye nekliniki.Ngaphezu koko, le ngqungquthela ibonise isithembiso njenge-agent antibacterial agent.Ibonise umsebenzi ochasene neendidi ezahlukeneyo zebhaktheriya, kuquka zombini iibhaktheriya ze-Gram-positive kunye ne-Gram-negative.Ukukwazi ukujolisa kwiintlobo ezininzi kuphakamisa amandla ayo ekulweni iibhaktheriya ezinganyangekiyo ngamachiza, eziye zaba yinkxalabo enkulu yempilo yehlabathi.Uphando olongezelelweyo lufanelekile ukuphanda indlela yokusebenza kunye nokuvavanya ukusebenza kwayo ekulweni nokusuleleka kwebhaktheriya.Ukwengeza, i-pyrazolo [3,4-c] i-pyridine derivatives, kubandakanywa le ngqungquthela, ibonise amandla onyango lwezifo ezivuthayo kunye nezifo ezizimele.Ukuvuvukala kudlala indima ebalulekileyo kwiimeko ezahlukeneyo ezifana ne-rheumatoid arthritis kunye ne-psoriasis.Ezi ziphuma zibonise iipropati ezichasayo ngokuhlengahlengisa iindlela ezithile ezibandakanyekayo kwimpendulo yokuvuvukala.Oku kuphakamisa amandla abo njengee-agent zonyango zokulawula ukuvuvukala okungapheliyo kunye nezifo ezinxulumene nazo.Ngaphezu koko, le ngqungquthela ibonise umsebenzi kwinkqubo ye-nervous central (CNS).Iphandwe ngesakhono sayo kwiziphazamiso zemithambo-luvo ezifana nesifo sika-Alzheimer kunye nesifo sikaParkinson.Ikhompawundi inokulungelelanisa ii-receptors ezithile kunye ne-enzymes ezibandakanyekayo ekuqhubekeni kwesifo, ezinokuthi zinike iziphumo ze-neuroprotective.Nangona kunjalo, uphando olongezelelweyo lufunekayo ukuze uqonde ngokupheleleyo indlela yokusebenza kwayo kunye nokuvavanya ukusebenza kwayo ekuphatheni ezi ngxaki eziyinkimbinkimbi. yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester inesithembiso kwiindawo ezininzi zonyango, kuquka ukulwa nomhlaza, ukuchasana nokudumba. , kunye nokuphazamiseka kwe-CNS.Ubunako bayo buxhomekeke ekukwazini ukujolisa kwiindlela ezithile kunye nabamkeli ababandakanyekayo kwezi meko.Nangona kunjalo, uphando olongezelelweyo kunye nophando luyimfuneko ukuphonononga ngokupheleleyo amandla alo, ukwandisa iipropathi zayo, kunye nokuvavanya ukhuseleko lwayo kunye nokusebenza kakuhle kwimimiselo yeklinikhi.